prEN 378-5
(Main)Refrigerating systems and heat pumps - Safety and environmental requirements - Part 5: Safety classification and information about refrigerants
Refrigerating systems and heat pumps - Safety and environmental requirements - Part 5: Safety classification and information about refrigerants
This document specifies criteria for safety and environmental considerations of different refrigerants used in refrigeration and air conditioning.This part of EN 378 specifies the classification and selection criteria applicable to refrigerating systems.These classification and selection criteria are used in prEN 378‑1, prEN 378‑2, prEN 378‑3 and ISO 5149‑4:2022. Product family standards dealing with the safety of refrigerating systems take precedence over horizontal and generic standards covering the same subject.
Kälteanlagen und Wärmepumpen - Sicherheitstechnische und umweltrelevante Anforderungen - Teil 5: Sicherheitsklassifikation und Informationen über Kältemittel
Dieses Dokument legt Kriterien für sicherheits- und umweltbezogene Überlegungen in Bezug auf verschiedene bei Kühlung und Klimatisierung eingesetzte Kältemittel fest.
Der vorliegende Teil von [2] legt die auf Kälteanlagen anwendbare(n) Klassifikation und Auswahlkriterien fest.
Diese Klassifikation und Auswahlkriterien werden in [3], [4], [5] und [1] angewendet.
Produktfamiliennormen bezüglich der Sicherheit von Kälteanlagen haben Vorrang gegenüber Sicherheitsfachgrundnormen und Sicherheitsgrundnormen desselben Anwendungsbereiches.
Systèmes frigorifiques et pompes à chaleur - Exigences de sécurité et d'environnement - Partie 5 : Classification de sécurité et informations sur les fluides frigorigènes
Le présent document spécifie les critères relatifs à la sécurité et aux aspects environnementaux de différents fluides frigorigènes utilisés en réfrigération et climatisation.
La présente partie du [2] spécifie les critères de classification et de choix applicables aux systèmes frigorifiques.
Ces critères de classification et de choix sont utilisés dans les [3], [4], [5] et [1].
Les normes de familles de produits traitant de la sécurité des systèmes frigorifiques prévalent sur les normes horizontales et génériques couvrant le même sujet.
Hladilni sistemi in toplotne črpalke - Varnostnotehnične in okoljevarstvene zahteve - 5. del: Varnostna klasifikacija in informacije o hladilnih sredstvih
General Information
Standards Content (Sample)
SLOVENSKI STANDARD
01-september-2025
Hladilni sistemi in toplotne črpalke - Varnostnotehnične in okoljevarstvene
zahteve - 5. del: Varnostna klasifikacija in informacije o hladilnih sredstvih
Refrigerating systems and heat pumps - Safety and environmental requirements - Part 5:
Safety classification and information about refrigerants
Kälteanlagen und Wärmepumpen - Sicherheitstechnische und umweltrelevante
Anforderungen - Teil 5: Sicherheitsklassifikation und Informationen über Kältemittel
Systèmes frigorifiques et pompes à chaleur - Exigences de sécurité et d'environnement -
Partie 5 : Classification de sécurité et informations sur les fluides frigorigènes
Ta slovenski standard je istoveten z: prEN 378-5
ICS:
27.080 Toplotne črpalke Heat pumps
27.200 Hladilna tehnologija Refrigerating technology
71.100.45 Hladiva in antifrizi Refrigerants and antifreezes
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
DRAFT
EUROPEAN STANDARD
NORME EUROPÉENNE
EUROPÄISCHE NORM
July 2025
ICS 27.080; 27.200; 71.100.45
English Version
Refrigerating systems and heat pumps - Safety and
environmental requirements - Part 5: Safety classification
and information about refrigerants
Systèmes frigorifiques et pompes à chaleur - Exigences Kälteanlagen und Wärmepumpen -
de sécurité et d'environnement - Partie 5 : Sicherheitstechnische und umweltrelevante
Classification de sécurité et informations sur les fluides Anforderungen - Teil 5: Sicherheitsklassifikation und
frigorigènes Informationen über Kältemittel
This draft European Standard is submitted to CEN members for enquiry. It has been drawn up by the Technical Committee
CEN/TC 182.
If this draft becomes a European Standard, CEN members are bound to comply with the CEN/CENELEC Internal Regulations
which stipulate the conditions for giving this European Standard the status of a national standard without any alteration.
This draft European Standard was established by CEN in three official versions (English, French, German). A version in any other
language made by translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC
Management Centre has the same status as the official versions.
CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and
United Kingdom.
Recipients of this draft are invited to submit, with their comments, notification of any relevant patent rights of which they are
aware and to provide supporting documentation.
Warning : This document is not a European Standard. It is distributed for review and comments. It is subject to change without
notice and shall not be referred to as a European Standard.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION
EUROPÄISCHES KOMITEE FÜR NORMUNG
CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2025 CEN All rights of exploitation in any form and by any means reserved Ref. No. prEN 378-5:2025 E
worldwide for CEN national Members.
Page
Contents
European foreword . 3
1 Scope . 4
2 Normative references . 4
3 Terms and definitions . 4
4 Safety classification of refrigerants . 4
Annex A (informative) Fluid group classification . 35
Bibliography. 36
European foreword
This document (prEN 378-5: 2025) has been prepared by Technical Committee CEN/TC "182", the
secretariat of which is held by Germany.
This document is currently submitted to the CEN Enquiry.
EN 378 consists of the following parts under the general title "Refrigerating systems and heat pumps —
Safety and environmental requirements":
— Part 1: Basic requirements, definitions, classification and selection criteria
— Part 2: Design, construction, testing, marking and documentation
— Part 3: Installation site and personal protection
— Part 5: Safety classification and information about refrigerants
[1] applies for operation, maintenance, repair and recovery.
1 Scope
This document specifies criteria for safety and environmental considerations of different refrigerants
used in refrigeration and air conditioning.
This part of [2] specifies the classification and selection criteria applicable to refrigerating systems.
These classification and selection criteria are used in [3], [4], [5] and [1].
Product family standards dealing with the safety of refrigerating systems take precedence over
horizontal and generic standards covering the same subject.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content
constitutes requirements of this document. For dated references, only the edition cited applies. For
undated references, the latest edition of the referenced document (including any amendments) applies.
prEN 378-1, Refrigerating systems and heat pumps - Safety and environmental requirements - Part 1:
Basic requirements, definitions, classification and selection criteria
3 Terms and definitions
For the purposes of this document, the terms and definitions given in prEN 378-1 apply.
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at http://www.iso.org/obp
— IEC Electropedia: available at http://www.electropedia.org/
4 Safety classification of refrigerants
Table 1, Table 2 and Table 3 list the refrigerants, their relevant safety classification and other relevant
information necessary for [3], [4], [5] and [1].
Refrigerants listed in Table 1, Table 2 and Table 3 use the designation and safety class specified in [6].
Practical limits values shall be those assigned in Table 1, Table 2 and Table 3.
The practical limit for a refrigerant represents the highest concentration level in an occupied space
which will not result in any escape impairing (i.e. acute) effects or create a risk of ignition of the
refrigerant. It is used to determine the maximum charge size for that refrigerant in a specific application.
For refrigerants including blends that were commercialised by 2003, the practical limits existing at that
time (as set in previous international or national standards) shall be maintained unless, for non-
flammable refrigerants, the ATEL/ODL values exceed the practical limit, in which case the ATEL/ODL
values shall be used.
The toxicity class of the refrigerant (A or B, the first character of the safety group) shall be according to
Table 1, Table 2 and Table 3.
The flammability class of the refrigerant (1, 2L, 2 or 3, being the part of the safety group after the first
character) shall be as indicated in Table 1, Table 2 and Table 3. Fluid group classification is determined
according to the Safety Data Sheet compliant with Annex II of Regulation (EC) No 1907/2006 (REACH)
[7]. See Annex A.
In Table 1, Table 2 and Table 3 the vapour density, molecular mass, normal boiling point (with bubble
point and dew point), azeotropic temperatures, ODP and GWP (AR5) are not part of this document and
are provided for information purposes only.
NOTE Further detailed information of refrigerants can be found on the safety data sheet.
Table 1 — Refrigerant designations
Vapou
GW
r Nor
l a f
PED GWP P Hot
densit mal
Practi
m
Safe ATEL/ (F- (AR Auto Surface
h
y boili
cal LFL Molec
g
Refrigerant Chemical ty flui ODL ODP Gas)( 6) ignition Ignition
b d
25 °C, ng
Chemical name limit (kg/ ular
3 a e
number formula clas d (kg/m 100 (10 tempera tempera
3 a
101,3 poin
(kg/ m ) mass
s gro ) yr 0 yr ture (°C) ture (°C)
a a
kPa t
m )
o
up ITH) ITH
(kg/m (°C)
)
)
Methane
series
i
11 Trichlorofluorometh CCI F A1 2 0,3 NF 5,62 5
j
0,0062 137,4 24 1 5 560 ND ND
ane 560
i
12 Dichlorodifluoromet CCI F A1 2 0,5 NF 4,94 – 11
2 2
j
0,088 120,9 1 11 200 ND ND
hane 29,0 200
12B1 Bromochlorodifluor CBrClF2 ND ND 0,2 NF 6,76 1
ND 165,4 – 4 3 1 930 ND ND
omethane 930
i
13 Chlorotrifluorometh CCIF3 A1 2 0,5 NF 4,27 16
ND 104,5 – 81 1 16 200 ND ND
ane 200
i
13B1 Bromotrifluorometh CBrF3 A1 2 0,6 NF 6,09 7
ND 148,9 – 58 10 7 200 ND ND
ane 200
trifluoroiodomethan 2 0,016 –
13I1 CF I A1 0,016 NF 195,9 1 1 ND ND
e 21,9
14 Carbon tetrafluoride CF4 A1 2 0,4 NF 3,60 7
j
0,40 88,0 – 128 0 7 380 ND ND
i
22 Chlorodifluorometha CHCIF2 A1 2 0,3 NF 3,54 0,05 1 ND
j
0,21 86,5 – 41 1 960 635
ne 5 960
14 ND
i
23 Trifluoromethane CHF A1 2 0,68 0,15 NF 2,86 70,0 – 82 0 14 800 765
Vapou
GW
r Nor
l a f
PED GWP P Hot
densit mal
Practi
m
Safe ATEL/ (F- (AR Auto Surface
h
y boili
cal LFL Molec
g
Refrigerant Chemical ty flui ODL ODP Gas)( 6) ignition Ignition
b d
25 °C, ng
Chemical name limit (kg/ ular
3 a e
number formula clas d (kg/m 100 (10 tempera tempera
3 a
101,3 poin
(kg/ m ) mass
s gro ) yr 0 yr ture (°C) ture (°C)
a a
kPa t
m )
o
up ITH) ITH
(kg/m (°C)
)
)
30 Dichloromethane CH2Cl2 B2 2 0,017 0,417 NA ND
ND 84,9 40 ND 11,2 11,2 662
(methylene chloride)
32 Difluoromethane CH2F2 A2L 1 0,061 2,13 ND
j
0,30 0,306 52,0 – 52 0 675 771 648
(methylene fluoride)
i
50 Methane CH4 A3 1 0,006 0,654 ND
0,0007 0,032 16,0 – 161 0 27,9 27,9 645
Ethane series
i
113 1,1,2-trichloro-1,2,2- CCl2FCClF2 A1 2 0,4 NF NA 6 ND
j
0,02 187,4 48 0,8 6 520 ND
trifluoroethane 520
i
114 1,2-dichloro-1,1,2,2- CClF CClF A1 2 0,7 NF 6,99 9 ND
2 2
j
0,14 170,9 4 1 9 430 ND
tetrafluoroethane 430
i
115 Chloropentafluoroet CCIF CF A1 2 0,76 NF 6,32 9 ND
2 3
j
0,76 154,5 – 39 0,6 9 600 ND
hane 600
116 Hexafluoroethane CF CF A1 2 0,68 NF 5,64 12 ND
3 3
0,68 138,0 – 78 0 12 200 ND
i
123 2,2-dichloro-1,1,1- CHCI CF B1 2 0,1
2 3 NF NA ND
j
0,057 153,0 27 0,02 90,4 90,4 730
trifluoroethane
i
124 2-chloro-1,1,1,2- CHCIFCF A1 2 0,11
3 NF 5,58 0,02 ND
j
0,056 136,5 – 12 597 597 ND
tetrafluoroethane 2
i
125 Pentafluoroethane CHF2CF3 A1 2 0,39 NF 4,91 3 ND
j
0,37 120,0 – 49 0 3 500 733
Vapou
GW
r Nor
l a f
PED GWP P Hot
densit mal
Practi
m
Safe ATEL/ (F- (AR Auto Surface
h
y boili
cal LFL Molec
g
Refrigerant Chemical ty flui ODL ODP Gas)( 6) ignition Ignition
b d
25 °C, ng
Chemical name limit (kg/ ular
3 a e
number formula clas d (kg/m 100 (10 tempera tempera
3 a
101,3 poin
(kg/ m ) mass
s gro ) yr 0 yr ture (°C) ture (°C)
a a
kPa t
m )
o
up ITH) ITH
(kg/m (°C)
)
)
i
134a 1,1,1,2- CH2FCF3 A1 2 0,25 NF 4,17 1 ND
j
0,21 102,0 – 26 0 1 430 743
tetrafluoroethane 530
141b 1,1-dichloro-1- CH3CCI2F ND 2 0,053 NA ND
j
0,012 NA 117,0 32 0,11 860 860 532
fluoroethane
142b 1-chloro-1,1- CH3CCIF2 A2 1 0,066 4,11 0,06 2 ND
j
0,10 0,329 100,5 – 10 2 300 750
difluoroethane 5 300
j
143a 1,1,1-trifluoroethane CH CF A2L 1 0,056 0,58 0,282 3,44 84,0 – 47 0 4 470 750
3 3
i
152a 1,1-difluoroethane CH CHF A2 1 0,027 2,70 ND
3 2
0,14 0,130 66,0 – 25 0 124 164 455
170 Ethane CH3CH3 A3 1 0,008 0,008 6 1,23 0,43 ND
0,038 30,0 – 89 0 0,437 515
j
6 7
Propane
series
218 Octafluoropropane CF3CF2CF3 A1 NF 7,69 9 ND
j
2 1,84 0,85 188,0 – 37 0 9 290 ND
227ea 1,1,1,2,3,3,3- CF3CHFCF3 A1 NF 6,95 3 ND
j
2 0,63 0,63 170,0 – 15 0 3 220 ND
heptafluoropropane 600
236fa 1,1,1,3,3,3- CF3CH2CF3 A1 NF 6,22 8 ND
i j
2 0,59 0,34 152,0 – 1 0 9 810 ND
hexafluoropropane 690
245fa 1,1,1,3,3- CF CH2CHF B1 NF 5,48 ND
3 2
2 0,19 0,19 134,0 15 0 1 030 962 ND
pentafluoropropane
Vapou
GW
r Nor
l a f
PED GWP P Hot
densit mal
Practi
m
Safe ATEL/ (F- (AR Auto Surface
h
y boili
cal LFL Molec
g
Refrigerant Chemical ty flui ODL ODP Gas)( 6) ignition Ignition
b d
25 °C, ng
Chemical name limit (kg/ ular
3 a e
number formula clas d (kg/m 100 (10 tempera tempera
3 a
101,3 poin
(kg/ m ) mass
s gro ) yr 0 yr ture (°C) ture (°C)
a a
kPa t
m )
o
up ITH) ITH
(kg/m (°C)
)
)
290 Propane CH3CH2CH3 A3 1,80 ND
1 0,008 0,09 0,038 44,0 – 42 0 0,02 0,02 470
cis-2,3,3,3-
1224y
tetrafluoro-1-chloro- CF3CF=CHCl A1 2 0,36 0,36 NF 6,33 148,5 14 ~0 0,06 1 ND ND
d(Z)
1-propene
Trans-1-chloro- 5,34 ND
0,45
1233z 3,3,3-trifluoroprop- CF3CH = CH 0,086 0,086 NF 130,5 18,1 ~0 3,88 ND
d(E) 1-ene Cl A1 2
1234yf 2,3,3,3- CF3CF = CH2 A2L 4,66 >800
– 0,50
j
tetrafluoroprop-1- 1 0,058 0,47 0,289 114,0 0 0,501 405
29,5 1
ene
1234ze Trans-1,3,3,3- CF CF = CHF A2L 4,66 ND
n
(E) tetrafuoroprop-1- 2 0,061 0,28 0,303 114,0 – 19 0 1,37 1,37 368
ene
1270 Propene (propylene) CH3CH = CH2 A3 0,001 7 1,72 ND
i
1 0,008 0,046 42,1 – 48 0 0 0 455
j k
Ethene series
1130(E) Trans-1,2- CHCl=CHCl B2 NA ND
1 0,004 0,004 0,257 96,9 47,7 ~0 0 0 ND
dichloroethene
(E) 1,2- (E)- –
1132(E) B2 0,023 0,079 0,115 64,0
...
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