Automated liquid handling systems – Uncertainty of the measurement procedures

This document describes the measurement uncertainty analysis of the measurement procedures described in ISO 23783-2, following the approach described in ISO/IEC Guide 98-3. This document also includes the determination of other uncertainty components related to the liquid delivery process and the device under test (DUT) to estimate the overall measurement uncertainty of delivered volumes by an automated liquid handling system (ALHS).

Systèmes automatisés de manipulation de liquides – Incertitude des modes opératoires de mesure

General Information

Status
Published
Publication Date
13-May-2024
Current Stage
6060 - International Standard published
Start Date
14-May-2024
Completion Date
14-May-2024
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Standards Content (Sample)

Technical
Report
ISO/TR 6037
First edition
Automated liquid handling systems
2024-05
– Uncertainty of the measurement
procedures
Systèmes automatisés de manipulation de liquides – Incertitude
des modes opératoires de mesure
Reference number
ISO/TR 6037:2024(en) © ISO 2024

---------------------- Page: 1 ----------------------
ISO/TR 6037:2024(en)
COPYRIGHT PROTECTED DOCUMENT
© ISO 2024
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland

© ISO 2024 – All rights reserved
ii

---------------------- Page: 2 ----------------------
ISO/TR 6037:2024(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 General procedure for the uncertainty calculation . 1
5 Modelling of the measurement . 2
6 Standard uncertainty components associated with the measuring system . 2
6.1 General information on standard uncertainty components estimation.2
6.2 Specific information on standard uncertainty components estimation.3
7 Standard uncertainty components associated with the ALHS . 3
7.1 General .3
7.2 ALHS-type specific influencing parameters .3
7.3 Test liquid properties influencing ALHS operation .3
7.4 Standard uncertainty of ALHS resolution .4
7.5 Standard uncertainty of cubic expansion coefficient (optional) .4
7.6 Standard uncertainty associated with air cushion effects (optional) .4
8 Repeatability and reproducibility of the liquid delivery process . 5
8.1 Repeatability (experimental standard deviation) .5
8.2 Reproducibility .5
9 Combined standard uncertainty of measurement associated with the systematic error
of mean volume .
...

FINAL DRAFT
Technical
Report
ISO/DTR 6037
ISO/TC 48
Automated liquid handling systems
Secretariat: DIN
– Uncertainty of the measurement
Voting begins on:
procedures
2024-01-31
Voting terminates on:
2024-03-27
RECIPIENTS OF THIS DRAFT ARE INVITED TO SUBMIT,
WITH THEIR COMMENTS, NOTIFICATION OF ANY
RELEVANT PATENT RIGHTS OF WHICH THEY ARE AWARE
AND TO PROVIDE SUPPOR TING DOCUMENTATION.
IN ADDITION TO THEIR EVALUATION AS
BEING ACCEPTABLE FOR INDUSTRIAL, TECHNO­
LOGICAL, COMMERCIAL AND USER PURPOSES, DRAFT
INTERNATIONAL STANDARDS MAY ON OCCASION HAVE
TO BE CONSIDERED IN THE LIGHT OF THEIR POTENTIAL
TO BECOME STAN DARDS TO WHICH REFERENCE MAY BE
MADE IN NATIONAL REGULATIONS.
Reference number
ISO/DTR 6037:2024(en) © ISO 2024

---------------------- Page: 1 ----------------------
FINAL DRAFT
ISO/DTR 6037:2024(en)
Technical
Report
ISO/DTR 6037
ISO/TC 48
Automated liquid handling systems
Secretariat: DIN
– Uncertainty of the measurement
Voting begins on:
procedures
Voting terminates on:
RECIPIENTS OF THIS DRAFT ARE INVITED TO SUBMIT,
COPYRIGHT PROTECTED DOCUMENT
WITH THEIR COMMENTS, NOTIFICATION OF ANY
RELEVANT PATENT RIGHTS OF WHICH THEY ARE AWARE
AND TO PROVIDE SUPPOR TING DOCUMENTATION.
© ISO 2024
IN ADDITION TO THEIR EVALUATION AS
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
BEING ACCEPTABLE FOR INDUSTRIAL, TECHNO­
LOGICAL, COMMERCIAL AND USER PURPOSES, DRAFT
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
INTERNATIONAL STANDARDS MAY ON OCCASION HAVE
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
TO BE CONSIDERED IN THE LIGHT OF THEIR POTENTIAL
or ISO’s member body in the country of the requester.
TO BECOME STAN DARDS TO WHICH REFERENCE MAY BE
MADE IN NATIONAL REGULATIONS.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland Reference number
ISO/DTR 6037:2024(en) © ISO 2024

© ISO 2024 – All rights reserved
ii

---------------------- Page: 2 ----------------------
ISO/DTR 6037:2024(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 General procedure for the uncertainty calculation . 1
5 Modelling of the measurement . 2
6 Standard uncertainty components associated with the measuring system . 2
6.1 General information on standard uncertainty components estimation.2
6.2 Specific information on standard uncertainty components estimation.3
7 Standard uncertainty components associated with the ALHS . 3
7.1 General .3
7.2 ALHS-type specific influencing parameters .3
7.3 Test liquid properties influencing ALHS operation .
...

ISO/DTR 6037:2023(E)
ISO /TC 48/WG 5
Date: 2023-10-12
Secretariat: DIN
Automated liquid handling systems – Uncertainty of the
measurement procedures

DTR stage

Warning for WDs and CDs
This document is not an ISO International Standard. It is distributed for review and comment. It is subject to
change without notice and may not be referred to as an International Standard.
Recipients of this draft are invited to submit, with their comments, notification of any relevant patent rights of
which they are aware and to provide supporting documentation.


A model manuscript of a draft International Standard (known as “The Rice Model”) is available at
https://www.iso.org/iso/model_document-rice_model.pdf

© ISO #### – All rights reserved

---------------------- Page: 1 ----------------------
ISO #####-#:####(X)
© ISO 20XX
2 © ISO #### – All rights reserved

---------------------- Page: 2 ----------------------
ISO/DTR 6037:2023(E2024(en)
© ISO 2024
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication
may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying,
or posting on the internet or an intranet, without prior written permission. Permission can be requested from either ISO
at the address below or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: + 41 22 749 01 11
EmailE-mail: copyright@iso.org
Website: www.iso.orgwww.iso.org
Published in Switzerland
© ISO #### 2024 – All rights reserved

iii

---------------------- Page: 3 ----------------------
ISO/DTR 6037:2023(E) 2024(en)
Contents
Foreword . x
Introduction. xi
1 Scope .1
2 Normative references .1
3 Terms and definitions .1
4 General procedure for the uncertainty calculation .1
5 Modelling of the measurement .2
6 Standard uncertainty components associated with the measuring system .2
6.1 General information on standard uncertainty components estimation .2
6.2 Specific information on standard uncertainty components estimation .3
7 Standard uncertainty components associated with the ALHS .3
7.1 General .3
7.2 ALHS-type specific influencing parameters .3
7.3 Test liquid properties influencing ALHS operation .3
7.4 Standard uncertainty of ALHS resolution .4
7.5 Standard uncertainty of cubic expansion coefficient (optional) .4
7.6 Standard uncertainty associated with air cushion effects (optional) .5
8 Repeatability and reproducibility of the liquid delivery process .5
8.1 Repeatability (experimental standard deviation) .
...

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