ISO/TS 19844:2015

Health informatics - Identification of medicinal products - Implementation guidelines for data elements and structures for the unique identification and exchange of regulated information on substances

ISO/TS 19844:2015 is used in the implementation of ISO 11238. ISO/TS 19844:2015 defines substances based on their scientific identity (i.e. what they are) rather than on their use or method of production. ISO 11238 provides the conceptual framework for defining substances and specified substances and for assigning unique identifiers in the context of the ISO IDMP standards. ISO 11238 describes general concepts for defining and distinguishing substances and a high level model for the structuring of information for substances. ISO/TS 19844:2015 provides detailed explanations of each type or grouping of substance information, an element-by-element description for implementation of ISO 11238, and examples for a variety of substances and specified substances. This first edition of ISO/TS 19844:2015 will only address substances, and Groups 1 to 3 of the specified substances as defined in ISO 11238 and Annexes A, B, C, and D. It is anticipated that specified substances Group 4, as defined in ISO 11238, will be addressed in a subsequent edition of ISO/TS 19844:2015. Some information that would typically fall under specified substances Group 4 may be covered in the Annexes of ISO/TS 19844:2015. This information, although not defining of either a substance or a specified substance Group 1, may be essential to distinguishing substances. ISO/TS 19844:2015 addresses the following: Data elements necessary for defining substances and specified substances Groups 1 to 3; The logical use of data elements as defined in ISO 11238; Substances and specified substances Groups 1 to 3 business rules for - determining necessary data elements, - distinguishing and defining materials according to ISO 11238, - triggering the assignment of identifiers.

Informatique de santé — Identification des médicaments — Lignes directrices pour la mise en oeuvre des éléments de données et structures pour l'identification unique et l'échange d'informations réglementées sur les substances

General Information

• Status: Withdrawn
• Publication Date: 14-Dec-2015
• Withdrawal Date: 14-Dec-2015
• ICS: 35.240.80 - IT applications in health care technology
• Technical Committee: ISO/TC 215 - Health informatics
• Drafting Committee: ISO/TC 215/WG 6 - Pharmacy and medicines business
• Current Stage: 9599 - Withdrawal of International Standard
• Start Date: 15-Dec-2016
• Completion Date: 13-Dec-2025

Relations

• Consolidates: ISO/TS 17518:2015 - Medical laboratories - Reagents for staining biological material - Guidance for users
• Effective Date: 06-Jun-2022
• Revised: ISO/TS 19844:2018 - Health informatics - Identification of medicinal products (IDMP) - Implementation guidelines for ISO 11238 for data elements and structures for the unique identification and exchange of regulated information on substances
• Effective Date: 16-Jul-2016
• Revised: ISO/TS 19844:2016 - Health informatics - Identification of medicinal products - Implementation guidelines for data elements and structures for the unique identification and exchange of regulated information on substances
• Effective Date: 16-Jan-2016
• Revised: ISO 11238:2012 - Health informatics - Identification of medicinal products - Data elements and structures for the unique identification and exchange of regulated information on substances
• Effective Date: 28-Dec-2013

Standards Content (Sample)

TECHNICAL ISO/TS
SPECIFICATION 19844
First edition
2015-12-15
Health informatics — Identification
of medicinal products —
Implementation guidelines for data
elements and structures for the
unique identification and exchange of
regulated information on substances
Informatique de santé — Identification des médicaments — Lignes
directrices pour la mise en oeuvre des éléments de données et
structures pour l’identification unique et l’échange d’informations
réglementées sur les substances
Reference number
©
ISO 2015
© ISO 2015, Published in Switzerland
All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form
or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior
written permission. Permission can be requested from either ISO at the address below or ISO’s member body in the country of
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ii © ISO 2015 – All rights reserved

Contents Page
Foreword . viii
Introduction . ix
1 Scope . 1
2 Normative references . 2
3 General background and history . 2
4 Substance (Mandatory) . 3
4.1 Introduction . 3
4.2 Defining Substances . 5
4.3 Substance Types (Mandatory). 7
4.4 Substance ID (Mandatory) . 10
4.5 Substance Names (Mandatory) . 11
4.5.1 Substance Name . 12
4.5.2 Substance Name Type . 12
4.5.3 Language . 13
4.5.4 Official Name (repeat as necessary) . 13
4.6 Reference Sources (Mandatory) . 15
4.6.1 Public Domain . 16
4.6.2 Reference Source Type. 16
4.6.3 Reference Source Class . 16
4.6.4 Reference Source ID . 17
4.6.5 Reference Source Citation . 17
4.6.6 Reference Source Document (new class to be included in the second edition of ISO 11238) . 17
4.6.7 Reference Source Document Type (new class to be included in the second edition of ISO
11238) . 18
4.6.8 Reference Source Document Classification (new class to be included in the second edition of
ISO 11238) . 18
4.6.9 Reference Source URL (new class to be included in the second edition of ISO 11238) . 18
4.7 Substance Code (Conditional) . 18
4.7.1 Code . 19
4.7.2 Code System . 19
4.7.3 Code System ID . 20
4.7.4 Code System Status . 20
4.7.5 Code System Status Change Date . 20
4.7.6 Comment . 20
4.7.7 Reference Source . 21
4.7.8 Substance Classification (repeat as necessary) . 21
4.7.9 Target . 23
4.7.10 Gene. 25
4.7.11 Gene Elements . 26
4.7.12 Substance Relationship . 27
4.8 Structure (repeat as necessary) (Conditional) . 29
4.8.1 Structural Representation Type . 34
4.8.2 Structural Representation . 35
4.8.3 Structural Representation Attachment . 35
4.8.4 Stereochemistry . 35
4.8.5 Optical Activity . 36
4.8.6 Molecular Formula . 36
4.8.7 Molecular Formula by Moieties (new class to be included in the second edition of ISO 11238) . 37
4.8.8 Isotope (repeat as necessary) . 37
4.9 Amount (Conditional) . 38
4.9.1 Average . 38
4.9.2 Low Limit. 38
4.9.3 High Limit . 39
4.9.4 Unit . 39
4.9.5 Non-numeric Value . 39
4.10 Source Material (Conditional) . 39
4.10.1 Source Material Class. 40
4.10.2 Source Material Type . 41
4.10.3 Source Material state . 41
4.10.4 Organism ID . 41
4.10.5 Organism Name . 41
4.10.6 Development Stage . 42
4.10.7 Part Description (repeat as necessary) . 42
4.10.8 Fraction (repeat as necessary) . 42
4.10.9 Organism . 43
4.11 Modification (repeat as necessary) (Conditional) . 49
4.11.1 Modification Type . 50
4.11.2 Residue Modified . 51
4.11.3 Residue Site . 51
4.11.4 Structural Modification . 51
4.12 Property (Conditional) . 55
4.12.1 Property Type . 56
4.12.2 Property Name . 56
4.12.3 Property Parameters (new class to be included in the second edition of ISO 11238) . 56
4.12.4 Substance Name . 57
4.12.5 Substance ID. 57
4.12.6 Amount type . 57
4.13 Version (repeat as necessary) (Mandatory) . 57
4.13.1 Version Number . 57
4.13.2 Effective date . 58
4.13.3 Change Made . 58
5 Substance definitions . 58
5.1 Chemical Substance . 58
5.1.1 Structure . 59
5.1.2 Stoichiometric . 59
5.1.3 Stoichiometric Chemicals. 59
5.1.4 Comment . 62
5.1.5 Non- Stoichiometric Chemicals . 62
5.2 Proteins/ Peptides . 64
5.2.1 Microheterogeneity . 65
5.2.2 Sequence Type . 66
5.2.3 Number of subunits . 66
5.2.4 Disulfide Linkage . 66
5.2.5 Comment . 67
5.2.6 Protein Subunit (repeat as necessary) . 67
5.2.7 Molecular Weight (repeat as necessary) . 69
5.2.8 Glycosylation . 69
5.2.9 Structure . 71
5.2.10 Modification . 71
5.2.11 Property . 71
5.2.12 Molecular Weight . 71
5.3 Nucleic Acids . 72
5.3.1 Structure . 73
5.3.2 Sequence Type . 73
5.3.3 Number of Subunits. 73
5.3.4 Area of hybridisation . 74
iv © ISO 2015 – All rights reserved

5.3.5 Comment . 74
5.3.6 Nucleic Acid Subunit (repeat as necessary) . 74
5.3.7 Modification . 77
5.3.8 Property . 77
5.3.9 Molecular Weight . 77
5.4 Polymers –To be addressed in more detail in the next edition of this Technical Specification . 78
5.4.1 Substance Name . 79
5.4.2 Structure . 79
5.4.3 Polymer Class . 79
5.4.4 Polymer Geometry . 80
5.4.5 Copolymer Sequence type . 80
5.4.6 Comment . 80
5.4.7 Monomer Description (repeat as necessary) . 80
5.4.8 Structural Repeat (repeat as necessary) . 81
5.4.9 Molecular Weight (repeat as necessary) . 83
5.4.10 Property (repeat as necessary) . 83
5.4.11 Reference Source (repeat as necessary) . 83
5.5 Structurally-Diverse Substances . 83
5.5.1 herbals and Substances Used in the Preparation of Plant-Based Allergenic Extracts . 84
5.5.2 Vaccines — Annex addressing this will be included in the next edition of this Technical
Specification . 93
5.5.3 Purified Blood Products and Polyclonal Antibodies — Annex addressing this will be included
in the next edition of this Technical Specification . 93
5.5.4 Cells and Tissues — Annex addressing this will be included in the next edition of this
Technical Specification . 93
5.5.5 Minerals — Annex addressing this will be included in the next edition of this Technical
Specification . 93
5.6 Mixture Substance (repeat as necessary) . 94
5.6.1 Mixture Type . 94
5.6.2 Mixture Constituent (repeat as necessary) . 94
6 specified substance (Optional) . 95
6.1 specified substance Group 1 (repeat as necessary) . 96
6.1.1 specified substance Group 1 ID . 97
6.1.2 specified substance Group1 Name . 97
6.1.3 Substance Name (repeat as necessary). 97
6.1.4 Substance Code . 97
6.1.5 Version (repeat as necessary) . 97
6.1.6 Reference Sources . 97
6.1.7 Property (repeat as necessary) . 97
6.1.8 Fraction (new class to be included in the second edition of ISO 11238) . 98
6.1.9 Modification . 98
6.1.10 Reference Information (repeat as necessary) . 98
6.1.11 Constituent (repeat as necessary) . 98
6.1.12 Physical Form (repeat as necessary) . 99
6.2 specified substance Group 1 intended for herbal Substance and herbal Preparation . 100
6.2.1 specified substance Group 1 ID . 101
6.2.2 specified substance Group1 Name . 101
6.2.3 Reference Sources . 101
6.2.4 Fraction (new class to be included in the second edition of ISO 11238) . 101
6.2.5 Modification (new classes to be included in the second edition of ISO 11238) . 102
6.2.6 Constituent (repeat as necessary) . 102
6.2.7 Physical Form (repeat as necessary) . 103
6.3 specified substance Group 2 (repeat as necessary) . 104
6.3.1 specified substance Group2 ID . 107
6.3.2 specified substance Group2 Name . 107
6.3.3 Parent Substance ID . 107
6.3.4 Manufacturing . 107
6.4 specified substance Group 2 for herbal preparations . 111
6.4.1 specified substance Group2 ID . 111
6.4.2 specified substance Group2 Name . 111
6.4.3 Parent Substance ID . 111
6.4.4 Manufacturing . 112
6.4.5 Version (repeat as necessary) . 113
6.5 specified substance Group 3 (repeat as necessary) . 113
6.5.1 specified substance Group3 ID . 114
6.5.2 specified substance Group3 Name . 114
6.5.3 Parent Substance ID . 114
6.5.4 Grade . 115
6.5.5 Reference Source (repeat as necessary) . 115
6.5.6 Version (repeat as necessary) . 115
6.5.7 Reference Source (repeat as necessary) . 116
6.5.8 Version (repeat as necessary) . 116
Annex A (normative) Choosing a Substance ID . 117
A.1 Requesting a Substance ID and providing information . 117
Annex B (normative) Chemical Substance . 119
B.0 Introduction . 119
B.0.1 Proposal for the update of the ISO 11238 Substance standard . 120
B.0.2 Outline of Annex B . 122
B.1 Scope . 123
B.2 Terms and definitions . 123
B.3 Chemical Substance subtypes and Mixture Substance . 132
B.3.1 Substance type, Chemical substance . 132
B.3.2 Solid state forms of the Substance . 132
B.3.3 Need to substantiate the chemical structure, molecular formula and molecular weight . 135
B.3.4 Polymorphism . 136
B.3.5 Non-Stoichiometric chemical substances . 137
B.3.6 Mixture substance . 138
B.3.7 Multi substance material . 139
B.4 Discussion of the key elements of a chemical substance . 142
B.4.1 Identity of material . 142
B.4.2 Nomenclature . 142
B.4.3 Molecular formula . 142
B.4.4 Molecular weight . 143
B.4.5 Substance Structure . 143
B.4.6 Geometric Isomerism . 146
B.4.7 Stereo-descriptors in systematic nomenclature: Substance with one centre of Asymmetry . 147
B.4.8 Substance with two centres of Asymmetry, Epimers, Diastereomers . 148
B.4.9 Anomers . 148
B.4.10 Substance with more than two centres of Asymmetry (Mixture of stereoisomers) . 151
B.4.11 Conclusion for the Key elements . 152
B.4.12 Decision tree for a new Substance ID . 152
B.5 Discussing other elements of importance regarding the characteristics of a substance . 153
B.5.1 Introduction . 153
B.5.2 Naming Vegetable Oils . 153
B.5.3 Castor Oil and related products . 169
B.5.4 Properties to be captured, related to liquids (Gas), Nitrous oxide . 172
B.6 Examples . 177
B.6.1 Example 1: Amlodipine besilate . 178
B.6.2 Example 2: Ponatinib hydrochloride . 185
B.6.3 Example 3: Benzathine Benzylpenicillin tetrahydrate, sterilised. . 201
B.6.4 specified substance Group 2 information level . 206
B.6.5 specified substance Group 3 information level . 207
B.7 Radiopharmaceutical substance . 207
B.7.1 Introduction . 207
vi © ISO 2015 – All rights reserved

B.7.2 Example: Florbetapir F . 208
B.7.3 Identity of material, combining the elements for Florbetapir F, Substance and specified
substance information level. . 209
B.7.4 specified substance Group 2 information level . 214
Annex C (normative) Protein Substance . 215
C.1 Scope . 215
C.2 Introduction . 215
C.3 Peptide Substances . 216
C.3.1 Example IIIa: Protein Substance: Vasopressin . 216
C.3.2 Example IIIb: Desmopressin . 219
C.3.3 Example IIIc: Desmopressin Acetate. 223
C.3.4 Example IIId: Calcitonin Salmon. 227
C.3.5 Example IIIe: Human Insulin . 233
C.4 Element Group Protein, specified substance Group 1 . 235
C.4.1 Example IVa: Insulin Human Zinc Suspension (Amorphous), taken from EP/USP Monographs
for Zinc Suspensions . 235
C.4.2 Example IVb: Insulin Human Zinc Suspension (Crystalline), taken from EP/USP Monographs
for Zinc Suspensions . 236
C.4.3 Example IVc: Insulin Human Zinc Suspension taken from EP/USP Monographs for Zinc
Suspensions, including discussion for specified substance Group 3 information . 237
C.5 Element Group Protein, specified substance Group 2 . 240
C.5.1 Example Va: Synthetic Calcitonin Salmon-Manufacturer Company Acme . 240
C.5.2 specified substance Group 2 information level . 240
C.5.3 Example Vb: Recombinant Calcitonin Salmon-- Company Acme . 241
C.6 Element Group Protein, specified substance Group 3 . 241
C.6.1 Example: Calcitonin Salmon (Synthetic) specified substance Group 3 . 242
C.6.2 Example: Calcitonin Salmon (Recombinant) specified substance Group 3 . 242
C.7 Example Protein Substance Example of a Monoclonal Antibody conjugated Toxin . 243
C.8 Addendum: Microheterogeneity . 248
Annex D (normative) Nucleic Acid Substance . 249
D.1 Scope . 249
D.2 Introduction . 249
D.3 Examples . 250
D.3.1 Example: 5-Methylcytosine . 250
D.3.2 Example: A 5’-phosphate ribonucleotide . 251
D.4 Substances . 252
D.4.1 Example: Mipomersen Sodium information
...