ISO 11843-7:2025
(Main)Capability of detection — Part 7: Methodology based on stochastic properties of instrumental noise
Capability of detection — Part 7: Methodology based on stochastic properties of instrumental noise
This document specifies the practical use of the fundamental concepts in ISO 11843 in case of the background noise predominance in instrumental analysis. This document specifies basic methods to — extract the stochastic properties of the background noise, — use the stochastic properties to estimate the SD or CV of the response variable, and — calculate the minimum detectable value based on the SD or CV obtained above. The methods described in this document are useful for checking the detection of a certain substance by various types of measurement equipment in which the background noise of the instrumental output predominates over the other sources of measurement uncertainty. Feasible choices are visible and ultraviolet absorption spectrometry, atomic absorption spectrometry, atomic fluorescence spectrometry, luminescence spectrometry, liquid chromatography and gas chromatography.
Capacité de détection — Partie 7: Méthodologie basée sur les propriétés stochastiques du bruit instrumental
General Information
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Standards Content (Sample)
International
Standard
ISO 11843-7
Third edition
Capability of detection —
2025-04
Part 7:
Methodology based on stochastic
properties of instrumental noise
Capacité de détection —
Partie 7: Méthodologie basée sur les propriétés stochastiques du
bruit instrumental
Reference number
© ISO 2025
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ii
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Symbols and abbreviations . 3
5 Quantitative analysis and background noise . 4
5.1 Error sources of analysis .4
5.2 Random processes in background .4
6 Theories for precision . 5
6.1 Precision for intensity differences.5
6.2 Precision for area measurements . .6
7 Estimation of noise parameters . 8
7.1 Fourier transform .8
7.2 Auto-covariance function .9
7.3 Difference method .10
8 Procedures for estimation of SD .11
Annex A (informative) Derivation of Formula (7) .13
Annex B (informative) Derivation of Formula (11) . 14
Bibliography .16
iii
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
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The procedures used to develop this document and those intended for its further maintenance are described
in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types
of ISO document should be noted. This document was drafted in accordance with the editorial rules of the
ISO/IEC Directives, Part 2 (see www.iso.org/directives).
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Organization (WTO) principles in the Technical Barriers to Trade (TBT), see www.iso.org/iso/foreword.html.
This document was prepared by Technical Committee ISO/TC 69, Applications of statistical methods,
Subcommittee SC 6, Measurement methods and results.
This third edition cancels and replaces the second edition (ISO 11843-7:2018), which has been technically
revised.
The main changes are as follows:
— a new subclause 7.3 was created;
— subclause 6.3 of the second edition was renumbered as Clause 8.
A list of all parts in the ISO 11843 series can be found on the ISO website.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
iv
Introduction
The series of ISO 11843 is based on the probability distributions of the net state variable (measurand) for
both the linear and nonlinear calibration situations. The focus is implicitly, though sometimes explicitly,
on the uncertainty associated with an estimate of the measured response predominantly coming from the
baseline noise in instrumental analysis. In many, if not most, analytical instruments, the baseline noise is
considered the prime cause of uncertainty when the sample amount is as low as the minimum detectable
value. Within its domain of applicability, the method given in this document can dispense with the repetition
of real samples, thus helping to improve global environments by saving time and energy that would be
required by repetition.
Background noise exists ubiquitously in analytical instruments, whether or not a sample is applied to the
instrument. This document is concerned with mathematical methodologies for estimating the minimum
detectable value in case that the most predominant source of measurement uncertainty is background
noise. The minimum detectable value can directly and mathematically be derived from the stochastic
characteristics of the background noise.
The basic concept of this document is the mathematical description of the probability distribution of
the response variable in terms of mathematically well-defined random processes. This description
straightforwardly leads to the minimum detectable value. As for the relation of the response and measurand,
linear and nonlinear calibration functions can be applied. In this manner, compatibility with ISO 11843-2
and ISO 11843-5 is ensured.
The definition and applicability of the minimum detectable value are described in ISO 11843-1 and
ISO 11843-2; the definition and applicability of the precision profile are described in ISO 11843-5. The
precision profile expresses how the precision changes depending on the net state variable.
The minimum detectable value, x , is generally expressed in the unit of the net state variable. If the
d
calibration function is linear, the standard deviation (SD) or coefficient of variation (CV) of the response
variable estimated in this document can linearly be transformed to the SD or CV of the net state variable,
which in turn can be used for the estimation of the minimum detectable value, x .
d
If the calibration function is nonlinear, the precision profile of the response variable in this document needs
to be transformed to the precision profile of the net state variable as shown in ISO 11843-5. In this situation,
the contents of ISO 11843-5 can be used for this purpose without modification.
v
International Standard ISO 11843-7:2025(en)
Capability of detection —
Part 7:
Methodology based on stochastic properties of
instrumental noise
1 Scope
This document specifies the practical use of the fundamental concepts in ISO 11843 in case of the background
noise predominance in instrumental analysis.
This document specifies basic methods to
— extract the stochastic properties of the background noise,
— use the stochastic properties to estimate the SD or CV of the response variable, and
— calculate the minimum detectable value based on the SD or CV obtained above.
The methods described in this document are useful for checking the detection of a certain substance by
various types of measurement equipment in which the background noise of the instrumental output
predominates over the other sources of measurement uncertainty. Feasible choices are visible and ultraviolet
absorption spectrometry, atomic absorption spectrometry, atomic fluorescence spectrometry, luminescence
spectrometry, liquid chromatography and gas chromatography.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content constitutes
requirements of this document. For dated references, only the edition cited applies. For undated references,
the latest edition of the referenced document (including any amendments) applies.
ISO 3534-1, Statistics — Vocabulary and symbols — Part 1: General statistical terms and terms used in
probability
ISO 3534-2, Statistics — Vocabulary and symbols — Part 2: Applied statistics
ISO 3534-3, Statistics — Vocabulary and symbols — Part 3: Design of experiments
ISO 5725-1, Accuracy (trueness and precision) of measurement methods and results — Part 1: General principles
and definitions
ISO 11843-1, Capability of detection — Part 1: Terms and definitions
ISO 11843-2, Capability of detection — Part 2: Methodology in the linear calibration case
ISO 11843-5, Capability of detection — Part 5: Methodology in the linear and non-linear calibration cases
3 Terms and definitions
For the purposes of this document, the terms and definitions given in ISO 3534-1, ISO 3534-2, ISO 3534-3,
ISO 5725-1, ISO 11843-1, ISO 11843-2, ISO 11843-5 and the following apply.
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
3.1
precision profile
mathematical description of the standard deviation (SD) of the response variable [σ (X)] or net state variable
Y
[σ (X)] as a function of the net state variable
X
Note 1 to entry: The coefficient of variation (CV) of the response variable or net state variable as a function of the net
state variable is also referred to as a precision profile.
Note 2 to entry: Precision means the SD or (CV) of the observed response variable or SD or (CV) of the net state variable
when estimated by the calibration function (see ISO 11843-5).
[SOURCE: ISO 11843-5:2008, 3.4, modified — “coefficient of variation” has been removed and Note 1 to entry
has been added instead. Note 2 to entry has also been added.]
3.2
minimum detectable value of the net state variable
x
d
value of the net state variable in the actual state that will lead, with probability 1 – β, to the conclusion that
the system is not in the basic state
Note 1 to entry: Under the assumption that the SD, σ (X), of the net state variable is constant [(σ (X) = σ ], the minimum
X X X
detectable value, x , is defined as
d
xk=+k σ (1)
()
d c d X
where
k denotes a coefficient to specify the probability of an error of the fir
...
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