ASTM E1429-91(2004)
(Guide)Standard Guide for Assessing the Health Hazard of Pesticides to Applicators and Others with Potential Exposure (Withdrawn 2010)
Standard Guide for Assessing the Health Hazard of Pesticides to Applicators and Others with Potential Exposure (Withdrawn 2010)
SIGNIFICANCE AND USE
Concern over the toxic effects observed in tests on animals has demonstrated the need to assess hazards of many new, and some presently used, materials. The process described herein will help producers, regulatory agencies, and others to compare alternative materials efficiently and adequately, completely assess a final candidate material, or reassess the health hazard of a material already in use. The process is not intended for pesticide registration; this guide provides techniques for health hazard assessment.
Sequential assessment and feedback allow appropriate judgments concerning the efficient use of resources, thereby minimizing unnecessary testing and focusing effort on the information most pertinent to each material. For different materials and situations, hazard assessment will appropriately be based on substantially different amounts and kinds of biological, chemical, physical, and toxicological data.
Assessment of the health hazard of a material should never be considered complete for all time. Reassessment should be considered if new uses are discovered, the nature of the exposure changes, or new information on biological, chemical, physical, or toxicological properties becomes available.
Periodic review will help ensure that new information receives prompt and appropriate attention.
If a pesticide is transformed substantially into another chemical entity in the environment, the hazard of the transformed material(s) may need to be assessed.
SCOPE
1.1 This guide covers a stepwise process for using information concerning biological, chemical, physical, and toxicological properties of a pesticide or other chemical(s), or of a formulation to identify adverse effects that may occur to pesticide applicators or others with potential exposure.
1.2 The health hazard assessment process is complex and requires decisions at a number of points; thus, the validity of the assessment depends on the soundness of those decisions, as well as the soundness of the information used. All decisions should be based on carefully documented analyses so that an appropriate assessment can be completed, at the least cost, which is consistent with scientific validity.
1.3 This guide assumes that the reader is knowledgeable in animal toxicology and related pertinent areas, and relies heavily on the judgment of the evaluator, particularly in the area of chronic hazards.
1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
WITHDRAWN RATIONALE
This guide covers a stepwise process for using information concerning biological, chemical, physical, and toxicological properties of a pesticide or other chemical(s), or of a formulation to identify adverse effects that may occur to pesticide applicators or others with potential exposure.
Formerly under the jurisdiction of Committee E35 on Pesticides and Alternative Control Agents, this guide was withdrawn in October 2010 due to inactivity and a lack of interest.
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NOTICE: This standard has either been superseded and replaced by a new version or withdrawn.
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Designation:E1429–91(Reapproved 2004)
Standard Guide for
Assessing the Health Hazard of Pesticides to Applicators
1
and Others with Potential Exposure
This standard is issued under the fixed designation E1429; the number immediately following the designation indicates the year of
original adoption or, in the case of revision, the year of last revision. A number in parentheses indicates the year of last reapproval. A
superscript epsilon (´) indicates an editorial change since the last revision or reapproval.
1. Scope 3. Terminology
1.1 This guide covers a stepwise process for using informa- 3.1 Definitions of Terms Specific to This Standard:
tion concerning biological, chemical, physical, and toxicologi- 3.1.1 hazard identification—the process of determining
cal properties of a pesticide or other chemical(s), or of a whether exposure to an agent can cause an increase in the
formulation to identify adverse effects that may occur to incidence of a particular adverse health effect and whether the
pesticide applicators or others with potential exposure. adverse health effect is likely to occur in humans.
1.2 The health hazard assessment process is complex and 3.1.2 health hazard assessment—the identification and
requires decisions at a number of points; thus, the validity of evaluation of the adverse effects likely to result from specified
the assessment depends on the soundness of those decisions, as release(s) of a material.The estimate is only semi-quantitative.
well as the soundness of the information used. All decisions 3.1.3 human exposure concentration (HEC)—the concen-
should be based on carefully documented analyses so that an tration in the human environment based on application rate or
appropriate assessment can be completed, at the least cost, distribution, persistence in the environment, the chemical form
which is consistent with scientific validity. of the material, and location of the pesticide or formulation in
1.3 This guide assumes that the reader is knowledgeable in the air, on surfaces, in vegetation, or in soil.
animal toxicology and related pertinent areas, and relies 3.1.4 maximum safe concentration for humans (MSCH)—a
heavily on the judgment of the evaluator, particularly in the prediction of the highest concentration of a material that would
area of chronic hazards. have no unacceptable adverse effect on humans based on
1.4 This standard does not purport to address all of the toxicity testing in animals, clinical studies, and field experi-
safety concerns, if any, associated with its use. It is the ence.
responsibility of the user of this standard to establish appro- 3.2 For additional references to terms used in this guide, see
priate safety and health practices and determine the applica- Terminology E609 and E943.
bility of regulatory limitations prior to use.
4. Summary of Guide
2. Referenced Documents
4.1 Thisguidedescribesastepwiseprocessforassessingthe
2
2.1 ASTM Standards: risk of a pesticide, chemical, or formulation to applicators and
E609 Terminology Relating to Pesticides other individuals susceptible to exposure of pesticides by
E943 Terminology Relating to Biological Effects and Envi- considering the relationship between the material’s measured
ronmental Fate or estimated human exposure concentration(s) and the adverse
2.2 OSHA Standard: effects likely to result. Unavailable necessary information
3
29 CFR 1910.1200 Hazard Communication Standard concerning human exposure concentrations and adverse effects
is obtained through a stepwise program that starts with
inexpensive information and progresses to expensive informa-
1
This guide is under the jurisdiction ofASTM Committee E35 on Pesticides and
tion if necessary.At the end of each iteration, the estimated or
Alternative ControlAgents and is the direct responsibility of Subcommittee E35.26
measured human exposure concentration(s) is compared with
on Safety to Man.
Current edition approved Oct. 1, 2004. Published October 2004. Originally
information on possible adverse effects to determine the
approved in 1991. Last previous edition approved in 2000 as E1429 – 91 (2000).
adequacy of the available data for assessing the health hazard.
DOI: 10.1520/E1429-91R04.
2
If it is not possible to conclude that the health hazard is either
For referenced ASTM standards, visit the ASTM website, www.astm.org, or
contact ASTM Customer Service at service@astm.org. For Annual Book of ASTM minimal or potentially excessive, the available data are judged
Standards volume information, refer to the standard’s Document Summary page on
inadequate to characterize the health hazard. If desired, appro-
the ASTM website.
priate additional information is identified and obtained, so that
3
Available from Superintendent of Documents, U.S. Government Printing
Office, Washington, DC 20402.
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