ISO/TS 24672:2023

Nanotechnologies — Guidance on the measurement of nanoparticle number concentration

This document provides an overview of the methods used to determine the nanoparticle number concentration in liquid dispersions and aerosols. The methods described are the ensemble measurement techniques of differential centrifugal sedimentation (DCS), multi-angle dynamic light scattering (MDLS), small-angle X-ray scattering (SAXS) and ultraviolet-visible spectroscopy (UV-vis) and the particle counting methods of particle tracking analysis (PTA), resistive pulse sensing (RPS), single particle inductively coupled plasma mass spectrometry (spICP-MS), condensation particle counter (CPC), and differential mobility analysing system (DMAS). This document provides information on the use of each technique, along with considerations on sample preparation, advantages and limitations.

Nanotechnologies — Conseils pour la mesure de la concentration en nombre de nanoparticules

General Information

• Status: Published
• Publication Date: 05-Nov-2023
• ICS: 07.120 - Nanotechnologies
• Technical Committee: ISO/TC 229 - Nanotechnologies
• Drafting Committee: ISO/TC 229/JWG 2 - Measurement and characterization
• Parallel Committee: IEC/TC 113 - Nanotechnology for electrotechnical products and systems
• Current Stage: 6060 - International Standard published
• Start Date: 06-Nov-2023
• Due Date: 07-Oct-2023
• Completion Date: 06-Nov-2023

Standards Content (Sample)

TECHNICAL ISO/TS
SPECIFICATION 24672
First edition
2023-11
Nanotechnologies — Guidance on the
measurement of nanoparticle number
concentration
Nanotechnologies — Conseils pour la mesure de la concentration en
nombre de nanoparticules
Reference number
ISO/TS 24672:2023(E)
© ISO 2023

---------------------- Page: 1 ----------------------
ISO/TS 24672:2023(E)
COPYRIGHT PROTECTED DOCUMENT
© ISO 2023
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: [phone]
Email: [e-mail]
Website: www.iso.org
Published in Switzerland
ii
  © ISO 2023 – All rights reserved

---------------------- Page: 2 ----------------------
ISO/TS 24672:2023(E)
Contents Page
Foreword .v
Introduction . vi
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 4
5 Overview . 5
5.1 General . 5
5.2 Comparison of different techniques . 5
5.3 Considerations when selecting a technique . 8
5.3.1 General . 8
5.3.2 Type of particles. 8
5.3.3 Number concentration range . 9
5.3.4 Accuracy and precision . 9
5.3.5 Other factors . 10
5.4 Unit for nanoparticle number concentration . 10
6 Ensemble techniques . .11
6.1 Differential centrifugal sedimentation . 11
6.1.1 General . 11
6.1.2 Sample specifications .
...

TECHNICAL ISO/TS
SPECIFICATION 24672
First edition
Nanotechnologies — Guidance on the
measurement of nanoparticle number
concentration
Nanotechnologies – Conseils pour la mesure de la concentration en
nombre de nanoparticules
PROOF/ÉPREUVE
Reference number
ISO/TS 24672:2023(E)
© ISO 2023

---------------------- Page: 1 ----------------------
ISO/TS 24672:2023(E)
COPYRIGHT PROTECTED DOCUMENT
© ISO 2023
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: [phone]
Email: [e-mail]
Website: www.iso.org
Published in Switzerland
ii
PROOF/ÉPREUVE © ISO 2023 – All rights reserved

---------------------- Page: 2 ----------------------
ISO/TS 24672:2023(E)
Contents Page
Foreword .v
Introduction . vi
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 4
5 Overview . 5
5.1 General . 5
5.2 Comparison of different techniques . 5
5.3 Considerations when selecting a technique . 8
5.3.1 General . 8
5.3.2 Type of particles. 8
5.3.3 Number concentration range . 9
5.3.4 Accuracy and precision . 9
5.3.5 Other factors . 10
5.4 Unit for nanoparticle number concentration . 10
6 Ensemble techniques . .11
6.1 Differential centrifugal sedimentation . 11
6.1.1 General . 11
6.1.2 Sample specifications .
...

ISO TR /TS 24672:2022 2023(E)
ISO TC 229/JWG 2
Date: 2022-03-02
Nanotechnologies — Guidance on the measurement of nanoparticle number
concentration
Nanotechnologies — Conseils pour la mesure de la concentration en nombre de
nanoparticules
First edition
Date: 2023-07-06

---------------------- Page: 1 ----------------------
ISO/TS 24672:2023(E)
© ISO 2022 2023
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no
part of this publication may be reproduced or utilized otherwise in any form or by any means,
electronic or mechanical, including photocopying, or posting on the internet or an intranet, without
prior written permission. Permission can be requested from either ISO at the address below or
ISO’sISO's member body in the country of the requester.
ISO Copyright Office
CP 401 • CH. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: + 41 22 749 01 11
Email: [e-mail] [e-mail]
Website: www.iso.orgwww.iso.org
Published in Switzerland.
ii © ISO 2023 – All rights reserved

---------------------- Page: 2 ----------------------
ISO/TS 24672:2023(E)
Contents
Foreword . 5
Introduction . 6
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 5
5 Overview . 5
5.1 General . 5
5.2 Comparison of different techniques . 6
5.3 Considerations when selecting a technique. 11
5.3.1 General . 11
5.3.2 Type of particles . 11
5.3.3 Number concentration range . 12
5.3.4 Accuracy and precision . 12
5.3.5 Other factors . 13
5.4 Unit for nanoparticle number concentration . 13
6 Ensemble techniques . 14
6.1 Differential centrifugal sedimentation . 14
6.1.1 General . 14
6.1.2 Sample specifications . 15
6.1.3 Technical aspects . 15
6.1.4 Sources of uncertainty and challenges . 18
6.1.5 Outlook . 18
6.2 Multi-angle dynamic light scattering . 19
6.2.1 General . 19
6.2.2 S
...