ISO/TR 23652:2024

Nanotechnologies — Considerations for radioisotope labelling methods of nanomaterials for performance evaluation

This document provides: a) a review of radioisotope labelling methods that can be used for nanomaterials; b) the advantages and disadvantages of each radioisotope labelling method; c) information on the selection of a matched pair of nanomaterial and radioisotope labelling method to ensure the in vivo integrity of radioisotope-labelled nanomaterials or the stability of their performance.

Nanotechnologies — Considérations relatives aux méthodes de marquage radio-isotopique des nanomatériaux pour l'évaluation des performances

General Information

• Status: Published
• Publication Date: 10-Jun-2024
• ICS: 07.120 - Nanotechnologies
• Technical Committee: ISO/TC 229 - Nanotechnologies
• Drafting Committee: ISO/TC 229 - Nanotechnologies
• Current Stage: 6060 - International Standard published
• Start Date: 11-Jun-2024
• Completion Date: 11-Jun-2024

Standards Content (Sample)

Technical
Report
ISO/TR 23652
First edition
Nanotechnologies — Considerations
2024-06
for radioisotope labelling methods
of nanomaterials for performance
evaluation
Nanotechnologies — Considérations relatives aux méthodes de
marquage radio-isotopique des nanomatériaux pour l'évaluation
des performances
Reference number
ISO/TR 23652:2024(en) © ISO 2024

---------------------- Page: 1 ----------------------
ISO/TR 23652:2024(en)
COPYRIGHT PROTECTED DOCUMENT
© ISO 2024
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: [phone]
Email: [e-mail]
Website: www.iso.org
Published in Switzerland

© ISO 2024 – All rights reserved
ii

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ISO/TR 23652:2024(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 2
5 Biodistribution study and radioisotopes. 3
5.1 Biodistribution study .3
5.2 Radioisotopes .3
6 Radioisotope labelling methods for nanomaterials . 4
6.1 General .4
6.2 Pre- and post-surface labelling method .6
6.3 Chelating agent-based labelling .6
6.4 Chelating agent-free radioisotope labelling method .8
6.4.1 General .8
6.4.2 Radioactive-plus-non-radioactive precursors .8
6.4.3 Specific trapping .8
6.4.4 Cation exchange .9
6.4.5 Neutron or proton beam activat
...

FINAL DRAFT
Technical
Report
ISO/DTR 23652
ISO/TC 229
Nanotechnologies — Considerations
Secretariat: BSI
for radioisotope labelling methods
Voting begins on:
of nanomaterials for performance
2024-02-20
evaluation
Voting terminates on:
2024-04-16
Nanotechnologies — Considérations relatives aux méthodes de
marquage radio-isotopique des nanomatériaux pour l'évaluation
des performances
RECIPIENTS OF THIS DRAFT ARE INVITED TO SUBMIT,
WITH THEIR COMMENTS, NOTIFICATION OF ANY
RELEVANT PATENT RIGHTS OF WHICH THEY ARE AWARE
AND TO PROVIDE SUPPOR TING DOCUMENTATION.
IN ADDITION TO THEIR EVALUATION AS
BEING ACCEPTABLE FOR INDUSTRIAL, TECHNO­
LOGICAL, COMMERCIAL AND USER PURPOSES, DRAFT
INTERNATIONAL STANDARDS MAY ON OCCASION HAVE
TO BE CONSIDERED IN THE LIGHT OF THEIR POTENTIAL
TO BECOME STAN DARDS TO WHICH REFERENCE MAY BE
MADE IN NATIONAL REGULATIONS.
Reference number
ISO/DTR 23652:2024(en) © ISO 2024

---------------------- Page: 1 ----------------------
FINAL DRAFT
ISO/DTR 23652:2024(en)
Technical
Report
ISO/DTR 23652
ISO/TC 229
Nanotechnologies — Considerations
Secretariat: BSI
for radioisotope labelling methods
Voting begins on:
of nanomaterials for performance
evaluation
Voting terminates on:
Nanotechnologies — Considérations relatives aux méthodes de
marquage radio-isotopique des nanomatériaux pour l'évaluation
des performances
RECIPIENTS OF THIS DRAFT ARE INVITED TO SUBMIT,
COPYRIGHT PROTECTED DOCUMENT
WITH THEIR COMMENTS, NOTIFICATION OF ANY
RELEVANT PATENT RIGHTS OF WHICH THEY ARE AWARE
AND TO PROVIDE SUPPOR TING DOCUMENTATION.
© ISO 2024
IN ADDITION TO THEIR EVALUATION AS
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
BEING ACCEPTABLE FOR INDUSTRIAL, TECHNO­
LOGICAL, COMMERCIAL AND USER PURPOSES, DRAFT
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on
INTERNATIONAL STANDARDS MAY ON OCCASION HAVE
the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below
TO BE CONSIDERED IN THE LIGHT OF THEIR POTENTIAL
or ISO’s member body in the country of the requester.
TO BECOME STAN DARDS TO WHICH REFERENCE MAY BE
MADE IN NATIONAL REGULATIONS.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: [phone]
Email: [e-mail]
Website: www.iso.org
Published in Switzerland Reference number
ISO/DTR 23652:2024(en) © ISO 2024

© ISO 2024 – All rights reserved
ii

---------------------- Page: 2 ----------------------
ISO/DTR 23652:2024(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 2
5 Biodistribution study and radioisotopes. 3
5.1 Biodistribution study .3
5.2 Radioisotopes .3
6 Radioisotope labelling methods for nanomaterials . 4
6.1 General .
...

ISO/DTR 23652
ISO/TC 229/WG 5
Secretariat: BSI
Date: 2024-02-06
Nanotechnologies — Considerations for radioisotope labelling
methods of nanomaterials for performance evaluation


Approval stage


Nanotechnologies — Considérations relatives aux méthodes de marquage radio-isotopique des nanomatériaux
pour l'évaluation des performances

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ISO/DTR 23652:2023(E:(en)
© ISO 20232024
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication
may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying,
or posting on the internet or an intranet, without prior written permission. Permission can be requested from either ISO
at the address below or ISO'sISO’s member body in the country of the requester.
ISO copyright office
Case postale 56 • CP 401 • Ch. de Blandonnet 8
CH-12111214 Vernier, Geneva 20
Tel. Phone: + 41 22 749 01 11
Fax + 41 22 749 09 47
E-mail: [e-mail]
Web www.iso.org
Website: www.iso.org
Published in Switzerland.
© ISO 2023 2024 – All rights reserved

ii

---------------------- Page: 2 ----------------------
ISO/DTR 23652:2023(E:(en)
Contents
Foreword . iv
Introduction . v
1 Scope .vi i
2 Normative references . 2
3 Terms and definitions . 2
4 Abbreviated terms . 3
5 Biodistribution study and radioisotopes . 4
5.1 Biodistribution study . 4
5.2 Radioisotopes . 5
6 Radioisotope labelling methods for nanomaterials . 5
6.1 General . 5
6.2 Pre- and post-surface labelling method. 7
6.3 Chelating agent-based labelling . 8
6.4 Chelating agent-free radioisotope labelling method . 11
6.4.1 General . 11
6.4.2 Radioactive-plus-non-radioactive precursors . 11
6.4.3 Specific trapping . 11
6.4.4 Cation exchange . 12
6.4.5 Neutron or proton beam activation . 13
6.5 Dual radioisotope labelling .
...