CEN/TS 16178:2012

Sludge, treated biowaste and soil - Determination of pharmaceutical products

This Technical Specification specifies a method to analyse pharmaceutical compounds in solid matrices. Pharmaceuticals analysis has been carried out on a LC/MS-MS quantum. The main difficulty in this project is the lack of sample certified in researched analytes. Even with spiked solid matrices it is still delicate to correctly verify the impact of extraction step, because it does not reproduce a real sample.
What is proposed here is an analytical method on pharmaceuticals products on sludge, soils and sediments.
This document provides a final protocol on the extraction and purification tested on sludge, soils and sediments spiked with pharmaceutical compounds.

Schlamm, behandelter Bioabfall und Boden - Bestimmung pharmazeutischer Produkte

Diese Technische Spezifikation legt ein Verfahren zur Analyse pharmazeutischer Verbindungen in festen Matrices fest. Analysen von Pharmazeutika wurden an einem LC/MS-MS-Quantum durchgeführt. Die größte Schwierigkeit dieses Projekts ist der Mangel an zertifizierten Proben der untersuchten Analyten. Sogar mit aufgestockten festen Matrices ist es noch schwierig, den Einfluss des Extraktionsschrittes korrekt zu verifizieren, da das Ergebnis nicht auf echte Proben übertragen werden kann. Dieses Dokument liefert ein abschließendes Protokoll zur Extraktion und Reinigung, das mit Schlamm, Boden und Sedimenten, die mit den in Tabelle 1 aufgeführten pharmazeutischen Verbindungen aufgestockt wurden, geprüft wurde.

Boues, biodéchets traités et sols - Détermination des produits pharmaceutiques

La présente Spécification technique définit une méthode pour analyser les composés pharmaceutiques dans
les boues, les biodéchets traités et les sols. L'analyse des produits pharmaceutiques a été effectuée selon
une technique CL/MS-MS quantum. La principale difficulté pour l’analyse réside dans l'absence de tout
échantillon certifié pour les analytes cibles. Même avec des matrices solides dopées, il est toujours délicat de
vérifier correctement l'impact de l'étape d'extraction, car celle-ci n’est pas transférable à un échantillon réel.
Ce document fournit un protocole final pour l'extraction et la purification, testé sur des boues, des sols et des
sédiments dopés par les composés pharmaceutiques énumérés dans le Tableau 1.

Blato, obdelani biološki odpadki in tla - Določevanje ostankov farmacevtskih sredstev

Ta tehnična specifikacija določa metodo za analizo farmacevtskih spojin v blatu, obdelanih bioloških odpadkih in tleh. Farmacevtska analiza je bila izvedena na kvantu LC/MS-MS. Glavna težava za analizo je pomanjkanje vzorca, potrjenega za ciljne analize. Tudi pri primešanih trdnih matrikah je še vedno težko pravilno preveriti vpliv postopka ekstrakcije, ker ga ni mogoče prenesti na realni vzorec.

General Information

• Status: Withdrawn
• Publication Date: 21-Feb-2012
• Withdrawal Date: 03-Oct-2017
• ICS: 13.030.01 - Wastes in general
• Technical Committee: CEN/TC 444 - Environmental characterization
• Drafting Committee: CEN/TC 444/WG 2 - Organic analysis
• Current Stage: 9960 - Withdrawal effective - Withdrawal
• Completion Date: 04-Oct-2017
• Directive: 86/278/EEC - Protection of the environment, and in particular of the soil, when sewage sludge is used in agriculture
• Mandate: M/330 - Mandate given to CEN for the development of horizontal standards in the fields of sludge, biowaste and soil.
• Ref Project: SIST-TS CEN/TS 16178:2012 - Sludge, treated biowaste and soil - Determination of pharmaceutical products

Standards Content (Sample)

SLOVENSKI STANDARD
SIST-TS CEN/TS 16178:2012
01-junij-2012
%ODWRREGHODQLELRORãNLRGSDGNLLQWOD'RORþHYDQMHRVWDQNRYIDUPDFHYWVNLK
VUHGVWHY
Sludge, treated biowaste and soil - Determination of pharmaceutical products
Schlamm, behandelter Bioabfall und Boden - Bestimmung pharmazeutischer Produkte
Boues, bio-déchets traités et sols - Détermination des produits pharmaceutiques
Ta slovenski standard je istoveten z: CEN/TS 16178:2012
ICS:
13.030.20 7HNRþLRGSDGNL%ODWR Liquid wastes. Sludge
13.080.10 .HPLMVNH]QDþLOQRVWLWDO Chemical characteristics of
soils
SIST-TS CEN/TS 16178:2012 en,fr,de
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

---------------------- Page: 1 ----------------------

SIST-TS CEN/TS 16178:2012

---------------------- Page: 2 ----------------------

SIST-TS CEN/TS 16178:2012


TECHNICAL SPECIFICATION
CEN/TS 16178

SPÉCIFICATION TECHNIQUE

TECHNISCHE SPEZIFIKATION
February 2012
ICS 13.030.01
English Version
Sludge, treated biowaste and soil - Determination of
pharmaceutical products
Boues, bio-déchets traités et sols - Détermination des Schlamm, behandelter Bioabfall und Boden - Bestimmung
produits pharmaceutiques pharmazeutischer Produkte
This Technical Specification (CEN/TS) was approved by CEN on 24 April 2011 for provisional application.

The period of validity of this CEN/TS is limited initially to three years. After two years the members of CEN will be requested to submit their
comments, particularly on the question whether the CEN/TS can be converted into a European Standard.

CEN members are required to announce the existence of this CEN/TS in the same way as for an EN and to make the CEN/TS available
promptly at national level in an appropriate form. It is permissible to keep conflicting national standards in force (in parallel to the CEN/TS)
until the final decision about the possible conversion of the CEN/TS into an EN is reached.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland,
Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and United Kingdom.





EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

Management Centre: Avenue Marnix 17, B-1000 Brussels
© 2012 CEN All rights of exploitation in any form and by any means reserved Ref. No. CEN/TS 16178:2012: E
worldwide for CEN national Members.

---------------------- Page: 3 ----------------------

SIST-TS CEN/TS 16178:2012
CEN/TS 16178:2012 (E)
Contents Page
Foreword .3
Introduction .4
1 Scope .5
2 Principle .5
3 Reagents .6
3.1 Chemicals .6
3.2 Pharmaceutical standards and internal standards for calibration .6
3.3 Preparation of stock solutions .7
3.4 Preparation of working solutions .7
4 Apparatus .7
5 Sample pretreatment .8
6 Extraction and clean-up .8
6.1 Extraction of a dry sample .8
6.2 Concentration .8
6.3 Clean-up .
...