EN ISO 21253-2:2019
(Main)Water quality - Multi-compound class methods - Part 2: Criteria for the quantitative determination of organic substances using a multi-compound class analytical method (ISO 21253-2:2019)
Water quality - Multi-compound class methods - Part 2: Criteria for the quantitative determination of organic substances using a multi-compound class analytical method (ISO 21253-2:2019)
This document specifies the criteria for developing an in-house mass spectrometry-based method for quantitative analysis of multiple subgroups of organic substances in the scope of physical-chemical analysis of water.
This document supplements ISO/TS 13530 which provides guidance on the initial characterization of the measurement performances, by providing details to select the test matrix and internal standards and criteria for analyte and internal standard recoveries.
This document is not intended as a substitute for the currently applicable analytical standards dedicated to organic compounds but as a resource bringing additional characterization elements.
Wasserbeschaffenheit - Gemeinsam erfassbare Stoffgruppen - Teil 2: Kriterien für die quantitative Bestimmung organischer Stoffe mit einem Multianalyt-Verfahren (ISO 21253-2:2019)
Dieses Dokument legt die Kriterien für die Entwicklung einer massenspektrometrischen laborinternen Methode zur quantitativen Analyse multipler Untergruppen organischer Stoffe im Rahmen der physikalisch-chemischen Untersuchung von Wasser fest.
Dieses Dokument ergänzt ISO/TS 13530, die Anleitung für die erstmalige Charakterisierung der Messleistungen bereitstellt, indem es detaillierte Angaben zur Auswahl der Prüfmatrix, der internen Standards und der Kriterien für die Wiederfindungen von Analyten und internen Standards macht.
Dieses Dokument ist nicht als Ersatz für die aktuell anzuwendenden Normen vorgesehen, die für die Analyse organischer Stoffe bestimmt sind, sondern vielmehr als Hilfsmittel, das weitere Charakterisierungselemente einbringt.
Qualité de l'eau - Méthodes d'analyse de composés multi-classes - Partie 2: Critères pour la détermination quantitative de composés organiques avec une méthode d'analyse de composés multi-classes (ISO 21253-2:2019)
Le présent document spécifie les critères pour le développement en interne d'une méthode fondée sur la spectrométrie de masse pour l'analyse quantitative de multiples sous-groupes de composés organiques dans le cadre d'une analyse physicochimique de l'eau.
Le présent document complète l'ISO/TS 13530 qui fournit des recommandations sur la caractérisation initiale des performances de mesure, en détaillant la sélection de la matrice d'essai et des étalons internes, ainsi que les critères pour la récupération de l'analyte et des étalons internes.
Le présent document n'a pas vocation à se substituer aux normes analytiques dédiées aux composés organiques actuellement en vigueur, mais est destiné à apporter des éléments de caractérisation supplémentaires.
Kakovost vode - Metode za več spojin - 2. del: Merila za kvantitativno določevanje organskih spojin z analizno metodo za več spojin (ISO 21253-2:2019)
Ta dokument določa kritična vprašanja, ki jih je treba obravnavati pri laboratorijski pripravi metode sočasne kvantitativne analize številnih organskih spojin v vodi.
General Information
Overview
EN ISO 21253-2:2019 - "Water quality - Multi-compound class methods - Part 2" provides criteria for developing and assessing in‑house mass spectrometry (MS)-based methods for the quantitative determination of multiple subgroups of organic substances in water. Published by CEN/ISO, this standard complements ISO/TS 13530 by giving practical details on selecting test matrices and internal standards and setting acceptance criteria for analyte and internal standard recoveries. It is intended as an additional resource - not a replacement for individual analytical standards for specific organic compounds.
Key topics and requirements
The standard focuses on method development and performance characterization for multi‑compound class analytical workflows, with emphasis on:
- Selection of the matrix - guidance for choosing representative test matrices for method verification and LOQ confirmation.
- Sample preservation - basic requirements for preserving water samples prior to extraction and MS analysis.
- Internal and injection standards - principles and criteria for selecting internal standards and injection standards to monitor method performance and correct for losses.
- Calibration strategies - calibration approaches applicable to external and internal calibration, including linearity considerations.
- Recovery determination - procedures and acceptance criteria for determining analyte recovery and internal standard recovery across subgroups of organic compounds.
- Limit of quantification (LOQ) - verification of LOQ in the intended matrix and related checks.
- Results and uncertainty - identification, quantification, and measurement uncertainty reporting considerations.
- Quality controls - blank checks, internal standard monitoring, LOQ validation and ongoing QC measures.
- Matrix effect (informative annex) - discussion of matrix effects on MS response and mitigation strategies.
Keywords: EN ISO 21253-2:2019, water quality, multi-compound class methods, mass spectrometry, internal standards, recovery, LOQ, calibration, matrix effect.
Practical applications and users
This standard is practical for organizations that develop or validate multi‑compound MS methods for water analysis:
- Environmental and public‑health laboratories performing routine monitoring of organic contaminants in surface water, groundwater and drinking water.
- Water utilities and contract testing labs implementing or validating in‑house LC–MS/MS or GC–MS/MS multi‑residue methods.
- Method developers and laboratory quality managers setting up QC procedures, recovery checks and LOQ verification.
- Regulatory bodies and accreditation assessors evaluating method fitness for purpose when standards for individual analytes are not prescriptive.
Related standards
- ISO/TS 13530 (initial performance characterization guidance)
- ISO 21253-1 (identification criteria for target compounds by GC/LC‑MS)
- ISO 8466 and ISO 11352 (calibration and uncertainty guidance)
EN ISO 21253-2:2019 adds specific, practical criteria for robust quantitative multi‑compound MS methods in water quality analysis, helping laboratories demonstrate reliable recoveries, calibration and LOQ verification across compound subgroups.
Frequently Asked Questions
EN ISO 21253-2:2019 is a standard published by the European Committee for Standardization (CEN). Its full title is "Water quality - Multi-compound class methods - Part 2: Criteria for the quantitative determination of organic substances using a multi-compound class analytical method (ISO 21253-2:2019)". This standard covers: This document specifies the criteria for developing an in-house mass spectrometry-based method for quantitative analysis of multiple subgroups of organic substances in the scope of physical-chemical analysis of water. This document supplements ISO/TS 13530 which provides guidance on the initial characterization of the measurement performances, by providing details to select the test matrix and internal standards and criteria for analyte and internal standard recoveries. This document is not intended as a substitute for the currently applicable analytical standards dedicated to organic compounds but as a resource bringing additional characterization elements.
This document specifies the criteria for developing an in-house mass spectrometry-based method for quantitative analysis of multiple subgroups of organic substances in the scope of physical-chemical analysis of water. This document supplements ISO/TS 13530 which provides guidance on the initial characterization of the measurement performances, by providing details to select the test matrix and internal standards and criteria for analyte and internal standard recoveries. This document is not intended as a substitute for the currently applicable analytical standards dedicated to organic compounds but as a resource bringing additional characterization elements.
EN ISO 21253-2:2019 is classified under the following ICS (International Classification for Standards) categories: 13.060.50 - Examination of water for chemical substances. The ICS classification helps identify the subject area and facilitates finding related standards.
You can purchase EN ISO 21253-2:2019 directly from iTeh Standards. The document is available in PDF format and is delivered instantly after payment. Add the standard to your cart and complete the secure checkout process. iTeh Standards is an authorized distributor of CEN standards.
Standards Content (Sample)
SLOVENSKI STANDARD
01-januar-2020
Kakovost vode - Metode za več spojin - 2. del: Merila za kvantitativno določevanje
organskih spojin z analizno metodo za več spojin (ISO 21253-2:2019)
Water quality - Multi-compound class methods - Part 2: Criteria for the quantitative
determination of organic substances using a multi-compound class analytical method
(ISO 21253-2:2019)
Wasserbeschaffenheit - Gemeinsam erfassbare Stoffgruppen - Teil 2: Kriterien für die
Beurteilung eines Multianalyt-Verfahrens organischer Stoffe (ISO 21253-2:2019)
Qualité de l'eau - Méthodes d'analyse de composés multi-classes - Partie 2: Critères
pour la détermination quantitative de composés organiques avec une méthode d'analyse
de composés multi-classes (ISO 21253-2:2019)
Ta slovenski standard je istoveten z: EN ISO 21253-2:2019
ICS:
13.060.50 Preiskava vode na kemične Examination of water for
snovi chemical substances
71.040.50 Fizikalnokemijske analitske Physicochemical methods of
metode analysis
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
EN ISO 21253-2
EUROPEAN STANDARD
NORME EUROPÉENNE
October 2019
EUROPÄISCHE NORM
ICS 13.060.50
English Version
Water quality - Multi-compound class methods - Part 2:
Criteria for the quantitative determination of organic
substances using a multi-compound class analytical
method (ISO 21253-2:2019)
Qualité de l'eau - Méthodes d'analyse de composés Wasserbeschaffenheit - Gemeinsam erfassbare
multi-classes - Partie 2: Critères pour la détermination Stoffgruppen - Teil 2: Kriterien für die Beurteilung
quantitative de composés organiques avec une eines Multianalyt-Verfahrens organischer Stoffe (ISO
méthode d'analyse de composés multi-classes (ISO 21253-2:2019)
21253-2:2019)
This European Standard was approved by CEN on 9 August 2019.
CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this
European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.
This European Standard exists in three official versions (English, French, German). A version in any other language made by
translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management
Centre has the same status as the official versions.
CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION
EUROPÄISCHES KOMITEE FÜR NORMUNG
CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2019 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN ISO 21253-2:2019 E
worldwide for CEN national Members.
Contents Page
European foreword . 3
European foreword
This document (EN ISO 21253-2:2019) has been prepared by Technical Committee ISO/TC 147 "Water
quality" in collaboration with Technical Committee CEN/TC 230 “Water analysis” the secretariat of
which is held by DIN.
This European Standard shall be given the status of a national standard, either by publication of an
identical text or by endorsement, at the latest by April 2020, and conflicting national standards shall be
withdrawn at the latest by April 2020.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
According to the CEN-CENELEC Internal Regulations, the national standards organizations of the
following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria,
Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland,
Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of
North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the
United Kingdom.
Endorsement notice
The text of ISO 21253-2:2019 has been approved by CEN as EN ISO 21253-2:2019 without any
modification.
INTERNATIONAL ISO
STANDARD 21253-2
First edition
2019-08
Water quality — Multi-compound
class methods —
Part 2:
Criteria for the quantitative
determination of organic substances
using a multi-compound class
analytical method
Qualité de l'eau — Méthodes d'analyse de composés multi-classes —
Partie 2: Critères pour la détermination quantitative de composés
organiques avec une méthode d'analyse de composés multi-classes
Reference number
ISO 21253-2:2019(E)
©
ISO 2019
ISO 21253-2:2019(E)
© ISO 2019
All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may
be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting
on the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address
below or ISO’s member body in the country of the requester.
ISO copyright office
CP 401 • Ch. de Blandonnet 8
CH-1214 Vernier, Geneva
Phone: +41 22 749 01 11
Fax: +41 22 749 09 47
Email: copyright@iso.org
Website: www.iso.org
Published in Switzerland
ii © ISO 2019 – All rights reserved
ISO 21253-2:2019(E)
Contents Page
Foreword .iv
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Principle . 3
5 Selection of the matrix . 3
6 Sample preservation prior to analysis. 4
7 Internal standards and injection standards . 4
7.1 General . 4
7.2 Selection of standards . 4
8 Calibration . 5
9 Recovery determination . 6
9.1 General . 6
9.2 Quantification by external calibration . 6
9.3 Quantification by internal calibration . 7
10 Limit of quantification (LOQ) . 7
11 Results . 7
11.1 Identification of the compounds . 7
11.2 Quantification . 7
11.3 Measurement uncertainty . 7
12 Quality controls . 7
12.1 General . 7
12.2 Quality control checks on the blank . 8
12.3 Quality control checks on the internal standards . 8
12.4 Quality control checks on the limit of quantification. 8
Annex A (informative) Matrix effect . 9
Bibliography .10
ISO 21253-2:2019(E)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out
through ISO technical committees. Each member body interested in a subject for which a technical
committee has been established has the right to be represented on that committee. International
organizations, governmental and non-governmental, in liaison with ISO, also take part in the work.
ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of
electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are
described in the ISO/IEC Directives, Part 1. In particular the different approval criteria needed for the
different types of ISO documents should be noted. This document was drafted in accordance with the
editorial rules of the ISO/IEC Directives, Part 2 (see www .iso .org/directives).
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of
any patent rights identified during the development of the document will be in the Introduction and/or
on the ISO list of patent declarations received (see www .iso .org/patents).
Any trade name used in this document is information given for the convenience of users and does not
constitute an endorsement.
For an explanation on the voluntary nature of standards, the meaning of ISO specific terms and
expressions related to conformity assessment, as well as information about ISO's adherence to the
World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT) see the following
URL: www .iso .org/iso/foreword .html.
This document was prepared by Technical Committee ISO/TC 147, Water quality, Subcommittee SC 2,
Physical, chemical and biochemical methods.
A list of all parts in the ISO 21253 series can be found on the ISO website.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www .iso .org/members .html.
iv © ISO 2019 – All rights reserved
INTERNATIONAL STANDARD ISO 21253-2:2019(E)
Water quality — Multi-compound class methods —
Part 2:
Criteria for the quantitative determination of organic
substances using a multi-compound class analytical method
1 Scope
This document specifies the criteria for developing an in-house mass spectrometry-based method for
quantitative analysis of multiple subgroups of organic substances in the scope of physical-chemical
analysis of water.
This document supplements ISO/TS 13530 which provides guidance on the initial characterization of
the measurement performances, by providing details to select the test matrix and internal standards
and criteria for analyte and internal standard recoveries.
This document is not intended as a substitute for the currently applicable analytical standards
dedicated to organic compounds but as a resource bringing additional characterization elements.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content
constitutes requirements of this document. For dated references, only the edition cited applies. For
undated references, the latest edition of the referenced document (including any amendments) applies.
ISO 8466-1, Water quality — Calibration and evaluation of analytical methods and estimation of
performance characteristics — Part 1: Statistical evaluation of the linear calibration function
ISO 8466-2, Water quality — Calibration and evaluation of analytical methods and estimation of
performance characteristics — Part 2: Calibration strategy for non-linear second-order calibration
functions
ISO 11352, Water quality — Estimation of measurement uncertainty based on validation and quality
control data
ISO 21253-1, Water quality — Multi- compound class methods — Part 1: Criteria for the identification of
target compounds by gas and liquid chromatography and mass spectrometry
3 Terms and definitions
For the purposes of this document, the following terms and definitions apply.
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https: //www .iso .org ./obp
— IEC Electropedia: available at http: //www .electropedia .org/
3.1
analyte
substance to be determined
[SOURCE: ISO/TS 28581:2012, 3.1]
ISO 21253-2:2019(E)
3.2
blank
aliquot of reagent water (reagent blank) or of a matrix in which the analyte (3.1) is absent (matrix blank)
that is treated exactly as a sample through the complete analytical procedure including extraction,
clean-up, identification and quantification including all the relevant reagents and materials
Note 1 to entry: It is crucial that the laboratory specifies which blank is considered.
3.3
calibration curve
expression of the relation between indication and corresponding measured quantity value
[SOURCE: ISO/IEC Guide 99:2007, 4.31]
3.4
limit of quantification
LOQ
lowest value of a determinand that can be determined with an acceptable level of accuracy, which could
be estimated by different means and shall be verified in the intended matrix
[SOURCE: ISO/TS 21231:2019, 3.2.5, modified — Note to entry has been excluded.]
3.5
analytical method
unambiguously written procedure describing all details required to carry out the analysis of the
determinand or parameter, namely: scope and field of application, principle and/or reactions,
definitions, reagents, apparatus, analytical procedures, calculations and presentation of results,
performance data and test report
[SOURCE: ISO/TS 16489:2006, 3.3]
3.6
recovery
relative recovery
extent to which a known, added quantity of determinand in a sample can be measured by an
analytical system
Note 1 to entry: Recovery is calculated from the difference between results obtained from a spiked and an
unspiked aliquot of sample and is usually expressed as a percentage.
[SOURCE: ISO 5667-14:2014, 3.8]
3.7
relative retention time
ratio between the retention time of the target compound and the retention time of the calibration
standard
[SOURCE: ISO 15680:2003, 3.5, modified — "retention-time standard" has been replaced by "calibration
standard"]
3.8
injection standard
standard mixture added to a sample before injection into the GC-MS apparatus, to monitor variability
of instrument response and to calculate internal standard recovery
Note 1 to entry: The same definition is applied for GC-MS/MS, LC-MS and LC-MS/MS.
[SOURCE: ISO 28540:2011, 3.4, modified — Note to entry has been replaced.]
2 © ISO 2019 – All rights reserved
ISO 21253-2:2019(E)
3.9
subgroup of compounds
analytes (3.1) pre-classified into groups that share similar patterns of analytical behaviour in response
to extraction mode and analysis
3.10
internal standard
compound added in a known amount to the sample from the beginning of the protocol and enabling
analytical coverage throughout the procedure, and that is used to correct for losses during sample
preparation and analysis by accounting for all-system matrix effects (recoveries, ionization effect,
variability of the detector response of the instrument for example)
Note 1 to entry: Determining the ratio of characteristic molecule signal intensity to the internal standard makes
it possible to calculate the quantitative ratio between molecule and internal standard and thereby to deduce
molecule concentration in
...
SIST EN ISO 21253-2:2020 표준은 물리-화학적 분석 범위 내에서 여러 유기 물질 하위 그룹의 정량적 분석을 위한 내부 질량 분석법 개발 기준을 명확하게 규정하고 있습니다. 이 문서는 ISO/TS 13530을 보완하여 측정 성능 초기 특성화에 대한 지침을 제공하며, 테스트 매트릭스와 내부 표준 선택에 대한 세부 사항 및 분석 물질 및 내부 표준 회수 기준을 명시하고 있습니다. 이 표준의 강점은 다양한 유기 물질의 정량적 분석을 가능하게 하는 다중 화합물 클래스 분석 방법을 지원하는 구조적 접근 방식을 제공한다는 점입니다. 그 결과, 물의 품질 평가에서 필요한 유기 물질의 정밀한 모니터링과 검출이 가능해집니다. 또한, 이 문서는 현재 적용 가능한 유기 화합물 분석 표준을 대체하려는 것이 아니라 추가적인 특성화 요소를 제공하는 자원으로 기능합니다. EN ISO 21253-2:2019 표준은 분석 수명 주기 전반에 걸쳐 유기 물질의 정량적 결정 기준을 마련하여, 연구 및 환경 평가를 위한 중요한 도구로 자리 잡고 있습니다. 따라서 이 표준은 물의 품질 관리를 위한 신뢰할 수 있는 기준을 제공하며, 그에 따라 지속 가능한 수자원 관리와 환경 보호를 지원하는데 큰 의의가 있습니다.
Die Norm EN ISO 21253-2:2019 bietet eine umfassende Grundlage für die quantitative Bestimmung organischer Substanzen in Wasser durch die Definition kritischer Kriterien für die Entwicklung einer massenspektrometrie-basierten Methode. Der Anwendungsbereich dieser Norm ist besonders relevant für die physikalisch-chemische Analyse von Wasser, da sie spezifische Anforderungen für die Analyse mehrerer Untergruppen organischer Verbindungen festlegt. Ein hervorstechendes Merkmal der Norm ist ihre ergänzende Funktion zu ISO/TS 13530, die zwar erste Leitlinien zur Charakterisierung der Messergebnisse bietet, jedoch durch EN ISO 21253-2:2019 entscheidende zusätzliche Elemente liefert. Diese Norm beschreibt detaillierte Verfahren zur Auswahl des Testmatrix, der internen Standards sowie Kriterien zur Wiederfindung von Analyten und internen Standards. Dadurch wird eine präzise und zuverlässige quantitative Analyse organischer Substanzen sichergestellt. Die Stärke der EN ISO 21253-2:2019 liegt in der Integration von modernen analytischen Technologien in die Wasseranalytik, was zur Verbesserung der Messgenauigkeit beiträgt. Sie erleichtert den Laboren die Entwicklung spezifischer Methoden und die Validierung bestehender Verfahren, wodurch die Wettbewerbsfähigkeit und die Qualität der analytischen Dienstleistungen gesteigert werden. Zudem unterstreicht die Norm die Relevanz von standardisierten Verfahren in der Wasseranalytik, insbesondere in Anbetracht der steigenden Anforderungen an Umweltstandards und -überwachung. Insgesamt ist die EN ISO 21253-2:2019 ein unverzichtbares Dokument für Fachleute, die in der wasseranalytischen Forschung und Industrie tätig sind. Sie bietet nicht nur die notwendigen Kriterien für eine präzise quantitative Bestimmung organischer Stoffe, sondern unterstützt auch die korrekte Anwendung von Massenspektrometrie in komplexen Wasserproben.
EN ISO 21253-2:2019の標準文書は、物理化学的分析の観点から、水質における有機物質の多様なサブグループを定量的に分析するための質量分析法に基づく方法の開発のための基準を明確に規定しています。この標準の適用範囲は、特に水質の評価において非常に重要であり、多成分クラス解析法を用いる際の定量分析に必要な基準を提供しています。この文書は、ISO/TS 13530に基づき、測定性能の初期特性に関するガイダンスを補足する形で、テストマトリックスおよび内部標準の選定、ならびに分析物および内部標準の回収率の基準を詳細に説明しています。 この標準の強みは、単に水質の分析を行うための基準を提示するだけでなく、分析の初期段階でのパフォーマンス評価に役立つ具体的な指針を提供している点です。これにより、研究者や技術者は、より信頼性の高い測定結果を得ることができ、複数の有機物質を同時に評価する際の精度が向上します。また、現在の有機化合物専用の分析標準の代わりではなく、これらを補完するリソースとしての役割を果たしているため、特定の分析ニーズに対して非常に関連性が高いと言えます。 この文書は、今後の水質モニタリングや環境分析において、重要な指針を提供し、より高度な定量分析を可能にするものであり、特に多成分同時分析における信頼性と効率の向上に寄与するが大きな魅力です。SIST EN ISO 21253-2:2020としての発行は、最新の水質評価において考慮されるべき重要な基準であると言えるでしょう。
The EN ISO 21253-2:2019 standard plays a crucial role in the domain of water quality analysis by providing a comprehensive framework for the quantitative determination of organic substances through multi-compound class analytical methods. Its scope is well-defined, focusing specifically on the criteria necessary for the development of an in-house mass spectrometry-based method, which is essential for analyzing various subgroups of organic compounds found in water. One of the key strengths of this standard is its thorough approach to supporting the physical-chemical analysis of water. It addresses the need for precise measurement performance characterization by supplementing ISO/TS 13530. By offering specific guidelines on selecting the appropriate test matrix, internal standards, and criteria for analyte and internal standard recoveries, the document significantly enhances the reliability and validity of the analytical process. Moreover, the EN ISO 21253-2:2019 standard is designed to complement existing analytical protocols dedicated to organic compounds, rather than replace them. This supplementary nature is beneficial, as it allows laboratories to adopt an enriched methodological framework without dismissing established practices. Consequently, this standard remains highly relevant in today’s context, as it adapts to the evolving needs of environmental monitoring and regulatory compliance. In summary, the EN ISO 21253-2:2019 standard is a pivotal resource for professionals engaged in water quality assessment, stemming from its clear scope and robust criteria for multi-compound class analytical methods. Its integration of additional characterization elements further solidifies its position as an essential reference in the quantitative analysis of organic substances in water.
La norme EN ISO 21253-2:2019 est un document essentiel qui établit des critères pour le développement d'une méthode interne basée sur la spectrométrie de masse pour l'analyse quantitative de multiples sous-groupes de substances organiques, spécifiquement dans le cadre de l'analyse physico-chimique de l'eau. Le champ d'application de cette norme est particulièrement pertinent pour les laboratoires cherchant à améliorer leurs méthodes d'analyse de la qualité de l'eau. Un des points forts de cette norme réside dans sa capacité à compléter l'ISO/TS 13530. Elle apporte un cadre détaillé pour le choix de la matrice de test ainsi que des normes internes, et fixe des critères pour les récupérations des analytes et des standards internes. Cela permet aux laboratoires de suivre des procédures rigoureuses lors de l'évaluation des performances de mesure, ce qui est fondamental pour garantir la fiabilité des résultats d'analyse de qualité de l'eau. En termes de pertinence, la norme EN ISO 21253-2:2019 n'a pas vocation à remplacer les normes analytiques actuellement en vigueur dédiées aux composés organiques, mais sert comme une ressource complémentaire. Elle enrichit le processus de caractérisation des méthodes analytiques en offrant des éléments supplémentaires pour l'évaluation de la qualité des données, notamment dans le contexte des substances organiques dans l'eau. Enfin, la norme se positionne comme un outil indispensable pour les laboratoires d'analyse, leur permettant de s'assurer que leur méthodologie respecte des critères rigoureux et scientifically validés, tout en contribuant à une meilleure compréhension des substances organiques présentes dans l'eau, ce qui est d'une importance cruciale pour la santé environnementale et humaine.
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