EN 17845:2023
(Main)Construction products: Assessment of release of dangerous substances - Determination of biocide residues using liquid chromatography with mass spectrometric detection (LC-MS/MS)
Construction products: Assessment of release of dangerous substances - Determination of biocide residues using liquid chromatography with mass spectrometric detection (LC-MS/MS)
This document describes a method for the determination of the content of biocides in construction products, (either finished (dried) or in a ready-to-use state) and in eluates thereof, using liquid chromatography and tandem mass spectrometric detection (LC-MS/MS).
For content analysis liquid chromatography with UV-detection can also be used, if sufficient sensitivity and selectivity is ensured (see Annex A (normative)).
The method in this document is validated for the product types listed in Annex D (informative). For eluate analysis quantification limits of 0,1 µg/l can be achieved.
Bauprodukte: Bewertung der Freisetzung von gefährlichen Stoffen - Bestimmung von Biozid-Rückständen mittels Flüssigchromatografie mit massenspektrometrischer Detektion (LC-MS/MS)
Dieses Dokument beschreibt ein Verfahren für die Bestimmung des Gehalts an Bioziden in Bauprodukten (entweder im fertigen (getrockneten) oder im gebrauchsfertigen Zustand) und in deren Eluaten mittels Flüssigchromatographie und Tandem-Massenspektrometrie (LC-MS/MS).
Für die Analyse des Gehalts kann auch Flüssigchromatographie mit UV-Detektion verwendet werden, wenn eine ausreichende Empfindlichkeit und Selektivität sichergestellt ist [siehe Anhang A (normativ)].
Das in diesem Dokument beschriebene Verfahren ist für die in Anhang D (informativ) aufgeführten Produkttypen validiert. Bei der Analyse von Eluaten können Quantifizierungsgrenzen von 0,1 µg/l erreicht werden.
Produits de construction : Évaluation de l'émission de substances dangereuses - Détermination de la teneur en biocides par chromatographie en phase liquide et détection par spectrométrie de masse en tandem (LC-MS/MS)
Le présent document décrit une méthode pour la détermination de la teneur en biocides dans les produits de construction [(finis (séchés) ou prêts à l'emploi] et dans leurs éluats, par chromatographie en phase liquide et détection par spectrométrie de masse en tandem (LC-MS/MS).
Pour l'analyse de contenu, la chromatographie en phase liquide avec détection d'UV peut également être utilisée, si une sensibilité et une sélectivité suffisantes sont assurées (voir l'Annexe A (normative)).
La méthode présentée dans le présent document est validée pour les types de produits énumérés à l'Annexe D (informative). Pour l'analyse des éluats, des limites de quantification de 0,1 µg/l peuvent être atteintes.
Gradbeni proizvodi - Ocenjevanje sproščanja nevarnih snovi - Določanje ostankov biocidov s tekočinsko kromatografijo in tandemsko masno spektrometrijo (LC-MS/MS)
Ta dokument opisuje metodo za določanje vsebnosti biocidov s tekočinsko kromatografijo in tandemsko masno spektrometrijo (LC-MS/MS) v gradbenih proizvodih (končnih (osušenih) ali v stanju, pripravljenem za uporabo) in v njihovih izlužkih.
Za analizo vsebine je mogoče uporabiti tudi tekočinsko spektrometrijo z detekcijo UV, če je zagotovljena zadostna občutljivost
in selektivnost (glej dodatek A (normativni)).
Metoda iz tega dokumenta je potrjena za vrste proizvodov, navedene v dodatku D (informativni). Za analizo izlužkov je mogoče doseči omejitve kvantifikacije 0,1 μg/l.
General Information
Standards Content (Sample)
SLOVENSKI STANDARD
01-april-2024
Gradbeni proizvodi - Ocenjevanje sproščanja nevarnih snovi - Določanje ostankov
biocidov s tekočinsko kromatografijo in tandemsko masno spektrometrijo (LC-
MS/MS)
Construction products - Assessment of release of dangerous substances - Determination
of biocide residues using liquid chromatography with mass spectrometric detection (LC-
MS/MS)
Bauprodukte - Bewertung der Freisetzung von gefährlichen Stoffen - Bestimmung von
Biozid-Rückständen mittels LC-MS/MS
Produits de construction - Évaluation de l'émission de substances dangereuses -
Détermination de la teneur en biocides par chromatographie en phase liquide et
détection par spectrométrie de masse en tandem (LC-MS/MS)
Ta slovenski standard je istoveten z: EN 17845:2023
ICS:
13.020.99 Drugi standardi v zvezi z Other standards related to
varstvom okolja environmental protection
71.040.50 Fizikalnokemijske analitske Physicochemical methods of
metode analysis
91.100.01 Gradbeni materiali na Construction materials in
splošno general
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
EN 17845
EUROPEAN STANDARD
NORME EUROPÉENNE
November 2023
EUROPÄISCHE NORM
ICS 91.100.01
English Version
Construction products: Assessment of release of
dangerous substances - Determination of biocide residues
using liquid chromatography with mass spectrometric
detection (LC-MS/MS)
Produits de construction : Évaluation de l'émission de Bauprodukte: Bewertung der Freisetzung von
substances dangereuses - Détermination de la teneur gefährlichen Stoffen - Bestimmung von Biozid-
en biocides par chromatographie en phase liquide et Rückständen mittels LC-MS/MS
détection par spectrométrie de masse en tandem (LC-
MS/MS)
This European Standard was approved by CEN on 14 August 2023.
CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this
European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.
This European Standard exists in three official versions (English, French, German). A version in any other language made by
translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management
Centre has the same status as the official versions.
CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION
EUROPÄISCHES KOMITEE FÜR NORMUNG
CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2023 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN 17845:2023 E
worldwide for CEN national Members.
Contents Page
European foreword . 4
Introduction . 5
1 Scope . 6
2 Normative references . 6
3 Terms and definitions . 6
4 Abbreviations . 8
5 Sample preparation . 9
6 Principle . 9
7 Reagents . 9
8 Apparatus and equipment .11
9 Procedure.12
9.1 Preparation and storage of the samples .12
9.2 Preparation of eluates .12
9.3 Sample preparation for content analysis .13
9.4 Determination .14
9.5 Test for interference and recovery .14
10 Evaluation of results .14
10.1 Identification .14
10.2 Quantification .15
10.3 Quality assurance .15
11 Calculation of results .16
11.1 Calculation of biocide concentrations without standard addition .16
11.2 Calculation of biocide concentrations with standard addition .17
12 Test performance .20
13 Test report .21
Annex A (normative) LC-UV method for content analysis .22
A.1 Extraction and clean-up .22
A.2 HPLC analysis .22
A.3 Example of chromatographic conditions .22
A.4 Calibration .23
A.4.1 General .23
A.4.2 Calibration curve .23
A.5 Calculation of biocide content in the construction product .24
Annex B (informative) Solid phase extraction of eluates (example) .25
Annex C (informative) Example conditions for suitable LC-MS/MS systems .26
Annex D (informative) Validation results for biocides in eluates from construction products
................................................................................................................................................................... 31
Bibliography . 33
European foreword
This document (EN 17845:2023) has been prepared by Technical Committee CEN/TC 351 “Construction
products: Assessment of release of dangerous substances”, the secretariat of which is held by NEN.
This European Standard shall be given the status of a national standard, either by publication of an
identical text or by endorsement, at the latest by May 2024, and conflicting national standards shall be
withdrawn at the latest by May 2024.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
This document has been prepared under a Standardization Request given to CEN by the European
Commission and the European Free Trade Association.
Any feedback and questions on this document should be directed to the users’ national standards body.
A complete listing of these bodies can be found on the CEN website.
According to the CEN-CENELEC Internal Regulations, the national standards organisations of the
following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria, Croatia,
Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland,
Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Republic of North
Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and the United
Kingdom.
Introduction
This document deals with the determination of the content of biocides in construction products and
eluates using liquid chromatography and tandem mass spectrometric detection (LC-MS/MS).
Following an extended evaluation of available methods for content and eluate analysis in construction
products (CEN/TR 16045) and subsequent method evaluation in the robustness validation [Van De
Weghe et al., 2018] it was concluded that eluate analysis and content analysis for biocides can be based
on EN 15637 after some modifications.
This document is part of a modular horizontal approach and belongs to the analytical step. An overview
of all modules which belong to a chain of measurement and the manner how modules are selected is given
in CEN/TR 16220.
In the growing amount of product and sector-oriented test methods it was recognized that many steps in
test procedures are or could be used in test procedures for many products, materials and sectors. It was
supposed that, by careful determination of these steps and selection of specific questions within these
steps, elements of the test procedure could be described in a way that can be used for all materials and
products or for all materials and products with certain specifications.
In this context a horizontal modular approach is adopted in CEN/TC 351. “Horizontal” means that the
methods can be used for a wide range of materials and products with certain properties. “Modular” means
that a test standard developed in this approach concerns a specific step in assessing a property and not
the whole “chain of measurement” (from sampling to analyses). A beneficial feature of this approach is
that “modules” can be replaced by better ones without jeopardizing the standard “chain”.
The use of modular horizontal standards implies the drawing of test schemes as well. Before executing a
test on a certain material or product to determine certain characteristics, it is necessary to draw up a
protocol in which the adequate modules are selected and together form the basis for the entire test
procedure.
1 Scope
This document describes a method for the determination of the content of biocides in construction
products, (either finished (dried) or in a ready-to-use state) and in eluates thereof, using liquid
chromatography and tandem mass spectrometric detection (LC-MS/MS).
For content analysis liquid chromatography with UV-detection can also be used, if sufficient sensitivity
and selectivity is ensured (see Annex A (normative)).
The method in this document is validated for the product types listed in Annex D (informative). For eluate
analysis quantification limits of 0,1 µg/l can be achieved.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content
constitutes requirements of this document. For dated references, only the edition cited applies. For
undated references, the latest edition of the referenced document (including any amendments) applies.
EN 16637-2, Construction products: Assessment of release of dangerous substances — Part 2: Horizontal
dynamic surface leaching test
EN 16637-3, Construction products: Assessment of release of dangerous substances — Part 3: Horizontal
up-flow percolation test
EN 16687:2023, Construction products: Assessment of release of dangerous substances — Terminology
EN 17087, Construction products: Assessment of release of dangerous substances — Preparation of test
portions from the laboratory sample for testing of release and analysis of content
3 Terms and definitions
For the purposes of this document, the terms and definitions given in EN 16687:2023 and the following
apply.
ISO and IEC maintain terminology databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https://www.iso.org/obp
— IEC Electropedia: available at https://www.electropedia.org/
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