ISO 16000-33:2024
(Main)Indoor air — Part 33: Determination of phthalates with gas chromatography/mass spectrometry (GC/MS)
Indoor air — Part 33: Determination of phthalates with gas chromatography/mass spectrometry (GC/MS)
This document specifies the sampling and analysis of phthalates in indoor air and describes the sampling and analysis of phthalates in house dust and in solvent wipe samples of surfaces by means of gas chromatography-mass spectrometry (GC-MS). Two alternative sampling, sample preparation and sample introduction methods, whose comparability has been proven in an interlaboratory test, are specified for indoor air[1]: — sorbent tubes sampling with subsequent thermal desorption GC-MS, and — sampling by adsorption and subsequent solvent extraction and injection to GC-MS. Additional adsorbents that can be used are described in Annex B. Depending on the sampling method, the compounds dimethyl phthalate to diisoundecylphthalate can be analysed in house dust as described in Annex D. The investigation of house dust samples is only appropriate as a screening method. This investigation only results in indicative values and is not acceptable for a final assessment of a potential need for action. Dimethyl phthalate to diisoundecylphthalate can be analysed in solvent wipe samples as described in Annex C. Solvent wipe samples are suitable for non-quantitative source identification. NOTE In principle, the method is also suitable for the analysis of other phthalates, adipates and cyclohexane dicarboxylic acid esters, but this is confirmed by determination of the performance characteristics in each case. General information on phthalates are given in Annex A.
Air intérieur — Partie 33: Détermination des phthalates par chromatographie en phase gazeuse/spectrométrie de masse (CPG/SM)
Notranji zrak - 33. del: Določanje ftalatov s plinsko kromatografijo z masno spektrometrijo (GC/MS)
General Information
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Standards Content (Sample)
International
Standard
ISO 16000-33
Second edition
Indoor air —
2024-07
Part 33:
Determination of phthalates
with gas chromatography/mass
spectrometry (GC/MS)
Air intérieur —
Partie 33: Détermination des phthalates par chromatographie en
phase gazeuse/spectrométrie de masse (CPG/SM)
Reference number
© ISO 2024
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ii
Contents Page
Foreword .v
Introduction .vi
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Abbreviated terms . 2
5 Sampling methods and analytical apparatus. 3
5.1 General .3
5.2 Sampling by adsorption with subsequent thermal desorption .3
5.2.1 Apparatus, operating materials and chemicals .3
5.2.2 Preparation of the thermal desorption tube .4
5.2.3 Sampling .4
5.3 Sampling by adsorption and subsequent solvent extraction .5
5.3.1 Apparatus, operating materials and chemicals .5 ®
5.3.2 Preparation of Florisil and the adsorption tubes .6 ®
5.3.3 Suggestions regarding the application of Florisil .6
5.3.4 Sampling .7
5.3.5 Sample conditioning .7
6 Calibration . 8
6.1 General .8
6.2 Calibration of the thermal desorption method .8
6.3 Calibration of the solvent extraction method .8
7 Identification and quantification . 9
7.1 Mass spectrometric analysis .9
8 Establishment of calibration curves and calculation of the analyte mass. 14
8.1 Establishment of a calibration curve .14
8.2 Calculation of the analyte mass . .14
9 Calculation of indoor air concentrations .15
10 Performance characteristics . 16
10.1 Detection limit .16
10.2 Quantification limit and problems related to blank values .16
10.3 Reproducibility standard deviation and repeatability standard deviation .17
11 Quality assurance .18
11.1 Method verification and determination of blanks .18
11.1.1 General .18
11.1.2 Field blank value of the indoor air .18
11.1.3 Analytical laboratory blank value .18
11.2 Measures for blank value minimization .18
11.3 Documents.19
12 Interferences . 19
Annex A (informative) General information on phthalates .20
Annex B (informative) Sampling by adsorption with ODS solid phase disk or SDB copolymer
cartridge .23
Annex C (informative) Screening phthalates in solvent wipe tests .29
Annex D (informative) Screening phthalates in house dust .32
Annex E (informative) Practical example for the calibration of the thermal desorption method .36
iii
Annex F (informative) Practical example for the calibration of the solvent extraction method ®
using Florisil .38
Annex G (informative) Practical example for the gas chromatography with thermal desorption .40
Annex H (informative) Practical example for the gas chromatography following solvent
extraction . 41
Annex I (informative) Problems related to the blank values .42
Annex J (informative) Example of sampling protocol documentation .43
Bibliography .44
iv
Foreword
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This document was prepared by Technical Committee ISO/TC 146, Air quality, Subcommittee SC 6, Indoor air.
This second edition cancels and replaces the first edition (ISO 16000-33:2017), which has been technically
revised.
The main change is as follows: a description of an adsorbent which can alternatively be used has been added.
A list of all parts in the ISO 16000 series can be found on the ISO website.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
v
Introduction
Different parts of the ISO 16000 series describe the general requirements relating to the measurement of
indoor air pollutants and the important conditions to be observed before or during the sampling of individual
pollutants or groups of pollutants, as well as the measurement procedures themselves.
The definition of indoor environment is given by ISO 16000-1. Dwellings [living rooms, bedrooms, do-it-
yourself (DIY) rooms, sports rooms and cellars, kitchens and bathrooms], workrooms or workplaces in
buildings which are not subject to health and safety inspections with respect to air pollutants (e.g. offices,
salesrooms), public buildings (e.g. restaurants, theatres, cinemas and other meeting rooms) and passenger
cabins of motor vehicles and public transport are among the
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