ASTM D6562-20
(Test Method)Standard Test Method for Determination of Gaseous Hexamethylene Diisocyanate (HDI) in Air with 9-(N-methylaminomethyl) Anthracene Method (MAMA) in the Workplace
Standard Test Method for Determination of Gaseous Hexamethylene Diisocyanate (HDI) in Air with 9-(N-methylaminomethyl) Anthracene Method (MAMA) in the Workplace
SIGNIFICANCE AND USE
5.1 HDI is mostly used in the preparation of paints. The use of isocyanates and their industrial needs have been in constant growth.
5.2 Diisocyanates and polyisocyanates are irritants to skin, eyes, and mucous membranes. They are recognized to cause respiratory allergic sensitization, asthmatic bronchitis, and acute respiratory intoxication (4-7).
5.3 The American Conference of Governmental Industrial Hygienists (ACGIH) has adopted a threshold limit value – time weighted average (TLV – TWA) of 0.005 ppm (V) or 0.034 mg/m3 (8). The Occupational Safety and Health Administration of the U.S. Department of Labor (OSHA) has not listed a permissible exposure limit (PEL) for HDI (9).
5.4 In any case, there are not separate exposure standards for vapor and aerosol. Therefore, in comparing the results for isocyanate against a standard, results from the two fractions should be combined to give a single total value.
5.5 Due to its low LOD and low required volume (15 L), this test method is well suited for monitoring of respiratory and other problems related to diisocyanates and polyisocyanates. Its short sampling times are compatible with the duration of many industrial processes, and its low detection limit with the concentrations often found in the working area.
SCOPE
1.1 This test method covers the determination of gaseous hexamethylene diisocyanate (HDI) in air samples collected from workplace and ambient atmospheres. The method described in this test method collects separate fractions. One fraction will be dominated by vapor, and the other fraction will be dominated by aerosol. The results obtained from the analysis of the separate fractions do not necessarily represent the true partition of the measured HDI physical phases, and should only be considered a representation of the general trend in the physical phase partition within samples. The analyses of the two fractions are different, and are provided in separate, linked, standards to avoid confusion. This test method is principally used to determine short term exposure (15 min) of HDI in workplace environments for personal monitoring or in ambient air. The analysis of the aerosol fraction is performed separately, as described in Test Method D6561.
1.2 Differential air sampling is performed with a segregating device. The vapor fraction is collected on a glass fiber filter (GFF) impregnated with 9-(N-methylaminomethyl) anthracene (MAMA).
1.3 The range of application of this test method has been validated from 0.006 to 1.12 μg of monomeric HDI/2.0 mL of desorption solution, which corresponds to concentrations equivalent to 0.0004 to 0.075 mg/m3 of HDI based on a 15 L air sample. Those concentrations correspond to a range of vapor phase concentrations from 0.06 ppb(V) to 11 ppb(V) and cover the established threshold limit value (TLV) value of 5 ppb(V).
1.4 The quantification limit for the monomeric HDI, using the UV detection, has been established as 0.012 μg/2 mL of desorption solution and as 0.008 μg/2 mL, using the fluorescence detector. These limits correspond to 0.0008 mg/m3 and 0.0005 mg/m3 respectively for an air sampled volume of 15 L. These values are equal to ten times the standard deviation (SD) obtained from ten measurements carried out on a standard solution in contact with the GFF, whose concentration of 0.02 μg/2 mL is close to the expected detection limit.
1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.
1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. See Section 9 for additional hazards.
1.7 This international standard was developed in accordance with internationally recogniz...
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This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the
Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.
Designation: D6562 − 20
Standard Test Method for
Determination of Gaseous Hexamethylene Diisocyanate
(HDI) in Air with 9-(N-methylaminomethyl) Anthracene
1
Method (MAMA) in the Workplace
This standard is issued under the fixed designation D6562; the number immediately following the designation indicates the year of
original adoption or, in the case of revision, the year of last revision. A number in parentheses indicates the year of last reapproval. A
superscript epsilon (´) indicates an editorial change since the last revision or reapproval.
3
1. Scope 0.0005 mg/m respectively for an air sampled volume of 15 L.
These values are equal to ten times the standard deviation (SD)
1.1 This test method covers the determination of gaseous
obtained from ten measurements carried out on a standard
hexamethylene diisocyanate (HDI) in air samples collected
solution in contact with the GFF, whose concentration of 0.02
from workplace and ambient atmospheres. The method de-
µg/2 mL is close to the expected detection limit.
scribed in this test method collects separate fractions. One
fraction will be dominated by vapor, and the other fraction will 1.5 The values stated in SI units are to be regarded as
be dominated by aerosol. The results obtained from the standard. No other units of measurement are included in this
analysis of the separate fractions do not necessarily represent standard.
the true partition of the measured HDI physical phases, and
1.6 This standard does not purport to address all of the
should only be considered a representation of the general trend
safety concerns, if any, associated with its use. It is the
in the physical phase partition within samples. The analyses of
responsibility of the user of this standard to establish appro-
the two fractions are different, and are provided in separate,
priate safety, health, and environmental practices and deter-
linked, standards to avoid confusion. This test method is
mine the applicability of regulatory limitations prior to use.
principally used to determine short term exposure (15 min) of
See Section 9 for additional hazards.
HDI in workplace environments for personal monitoring or in
1.7 This international standard was developed in accor-
ambient air. The analysis of the aerosol fraction is performed
dance with internationally recognized principles on standard-
separately, as described in Test Method D6561.
ization established in the Decision on Principles for the
Development of International Standards, Guides and Recom-
1.2 Differential air sampling is performed with a segregat-
mendations issued by the World Trade Organization Technical
ing device.The vapor fraction is collected on a glass fiber filter
Barriers to Trade (TBT) Committee.
(GFF) impregnated with 9-(N-methylaminomethyl) anthracene
(MAMA).
2. Referenced Documents
1.3 The range of application of this test method has been
2
2.1 ASTM Standards:
validated from 0.006 to 1.12 µg of monomeric HDI/2.0 mL of
D1193 Specification for Reagent Water
desorption solution, which corresponds to concentrations
3
D1356 Terminology Relating to Sampling and Analysis of
equivalent to 0.0004 to 0.075 mg/m of HDI based on a 15 L
Atmospheres
air sample. Those concentrations correspond to a range of
D1357 Practice for Planning the Sampling of the Ambient
vapor phase concentrations from 0.06 ppb(V) to 11 ppb(V) and
Atmosphere
cover the established threshold limit value (TLV) value of 5
D4840 Guide for Sample Chain-of-Custody Procedures
ppb(V).
D5337 Practice for Flow RateAdjustment of Personal Sam-
1.4 The quantification limit for the monomeric HDI, using
pling Pumps
the UV detection, has been established as 0.012 µg/2 mL of
D6561 Test Method for Determination of Aerosol Mono-
desorption solution and as 0.008 µg/2 mL, using the fluores-
mericandOligomericHexamethyleneDiisocyanate(HDl)
3
cence detector. These limits correspond to 0.0008 mg/m and
inAir with (Methoxy-2–phenyl-1) Piperazine (MOPIP) in
the Workplace
1
This test method is under the jurisdiction of ASTM Committee D22 on Air
Quality and is the direct responsibility of Subcommittee D22.04 on Workplace Air
2
Quality. For referenced ASTM standards, visit the ASTM website, www.astm.org, or
Current edition approved March 1, 2020. Published June 2020. Originally contact ASTM Customer Service at service@astm.org. For Annual Book of ASTM
approved in 2000. Last previous edition approved in 2012 as D6562 – 12. DOI: Standards volume information, refer to the standard’s Document Summary page on
10.1520/D6562-20. the ASTM website.
Copyright © ASTM International, 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959. United States
1
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This document is not an ASTM standard and is intended only to provide the user of an ASTM standard an indication of what changes have been made to the previous version. Because
it may not be technically possible to adequately depict all changes accurately, ASTM recommends that users consult prior editions as appropriate. In all cases only the current version
of the standard as published by ASTM is to be considered the official document.
Designation: D6562 − 12 D6562 − 20
Standard Test Method for
Determination of Gaseous Hexamethylene Diisocyanate
(HDI) in Air with 9-(N-methylaminomethyl) Anthracene
1
Method (MAMA) in the Workplace
This standard is issued under the fixed designation D6562; the number immediately following the designation indicates the year of
original adoption or, in the case of revision, the year of last revision. A number in parentheses indicates the year of last reapproval. A
superscript epsilon (´) indicates an editorial change since the last revision or reapproval.
1. Scope
1.1 This test method covers the determination of gaseous hexamethylene diisocyanate (HDI) in air samples collected from
workplace and ambient atmospheres. The method described in this test method collects separate fractions. One fraction will be
dominated by vapor, and the other fraction will be dominated by aerosol. It is not known at the present time whether this represents
a perfect separation of vapor and aerosol, and in any case, there are not separate exposure standards for vapor and aerosol.
Therefore, in comparing the results for isocyanate against a standard, results from the two fractions should be combined to give
a single total value. The reason for splitting the sample into two fractions is to increase analytic sensitivity for the vapor fraction
and also to give the hygienist or ventilation engineer some information concerning the likely state of the isocyanate species. The
results obtained from the analysis of the separate fractions do not necessarily represent the true partition of the measured HDI
physical phases, and should only be considered a representation of the general trend in the physical phase partition within samples.
The analyses of the two fractions are different, and are provided in separate, linked, standards to avoid confusion. This test method
is principally used to determine short term exposure (15 min) of HDI in workplace environments for personal monitoring or in
ambient air. The analysis of the aerosol fraction is performed separately, as described in Test Method D6561.
1.2 Differential air sampling is performed with a segregating device. The vapor fraction is collected on a glass fiber filter (GFF)
impregnated with 9-(N-methylaminomethyl) anthracene (MAMA).
1.3 The analysis of the gaseous fraction is performed with a high performance liquid chromatograph (HPLC) equipped with
ultraviolet (UV) and fluorescence detectors.
1.3 The range of application of this test method, using UV and fluorescence detectors both connected in serial, method has been
validated from 0.006 to 1.12 μg of monomeric HDI/2.0 mL of desorption solution, which corresponds to concentrations equivalent
3
to 0.0004 to 0.075 mg/m of HDI based on a 15-L 15 L air sample. Those concentrations correspond to a range of vapor phase
concentrations from 0.06 ppb(V) to 11 ppb(V) and cover the established threshold limit value (TLV) value of 5 ppb(V).
1.4 The quantification limit for the monomeric HDI, using the UV detection, has been established as 0.012 μg/2 mL of
3
desorption solution and as 0.008 μg/2 mL, using the fluorescence detector. These limits correspond to 0.0008 mg/m and 0.0005
3
mg/m respectively for an air sampled volume of 15 L. These values are equal to ten times the standard deviation (SD) obtained
from ten measurements carried out on a standard solution in contact with the GFF, whose concentration of 0.02 μg/2 mL is close
to the expected detection limit.
1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.
1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility
of the user of this standard to establish appropriate safety safety, health, and healthenvironmental practices and determine the
applicability of regulatory limitations prior to use. See Section 9 for additional hazards.
1.7 This international standard was developed in accordance with internationally recognized principles on standardization
established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued
by the World Trade Organization Technical Barriers to Trade (TBT) Committee.
1
This test method is under the jurisdiction of ASTM Committee D22 on Air Quality and is the direct responsibility of Subcommittee D22.04 on Workplace Air Quality.
Current edition approved April 1, 2012March 1, 2020. Published May 2012June 2020. Originally approved in 2000. L
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