SIST EN ISO 10298:2020/A1:2022
(Amendment)Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets - Amendment 1 (ISO 10298:2018/Amd 1:2021)
Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets - Amendment 1 (ISO 10298:2018/Amd 1:2021)
This document lists the best available acute-toxicity data of gases taken from a search of the current literature to allow the classification of gases and gas mixtures for toxicity by inhalation.
Scope of amendment
Changes to formula in clause 4.3
Gasflaschen - Gase und Gasgemische - Bestimmung der Toxizität zur Auswahl von Ventilausgängen - Änderung 1 (ISO 10298:2018/Amd 1:2021)
No scope available
Bouteilles à gaz - Gaz et mélanges de gaz - Détermination de la toxicité pour le choix des raccords de sortie de robinets - Amendement 1 (ISO 10298:2018/Amd 1:2021)
Plinske jeklenke - Plini in zmesi plinov - Določanje strupenosti plinov in njihovih zmesi za izbiro izhodnega priključka ventila na jeklenki - Dopolnilo A1 (ISO 10298:2018/Amd 1:2021)
General Information
Relations
Overview
EN ISO 10298:2020/A1:2022 (ISO 10298:2018/Amd 1:2021) is an amendment to the international standard for gas cylinders that provides authoritative guidance on the determination of toxicity for gases and gas mixtures to support the selection of cylinder valve outlets. The standard compiles best-available acute inhalation toxicity data from the literature so that gases and mixtures can be classified for toxicity by inhalation and appropriate valve outlet types can be selected to reduce handling and exposure risks.
Key topics and requirements
- Purpose: Use acute-toxicity data to classify gases/gas mixtures by inhalation toxicity for safe cylinder valve outlet selection.
- Data basis: Best-available LC50 (lethal concentration) values from current literature; emphasis on acute inhalation toxicity.
- Mixture calculation: Amendment 1 updates the mixture toxicity formula in clause 4.3. The revised formula for estimating the mixture LC50 is:
- 1/LC50 = Σi (Ci / LC50i)
- where Ci is the mole fraction of the i‑th toxic component and LC50i is the lethal concentration of that component (applicable when LC50i < 5 000 ppm by volume).
- Scope limitation: Focused on acute toxicity by inhalation; does not replace other hazard classifications (e.g., flammability, corrosivity).
- Conformance: CEN adoption means the amendment is implemented as a national standard in CEN member countries.
Practical applications and users
Who uses this standard:
- Gas cylinder manufacturers and cylinder valve designers selecting outlet connections based on toxicity classification.
- Industrial gas suppliers and distributors responsible for cylinder filling, labelling and outlet configuration.
- Safety engineers and occupational health professionals assessing inhalation risks and specifying control measures.
- Regulators, transport authorities and emergency responders using toxicity classification to inform handling, storage and incident response. Practical uses:
- Calculating mixture toxicity (LC50) using component mole fractions to determine if a more restrictive valve outlet is required.
- Informing cylinder labelling, safety data sheets (SDS) and workplace controls based on inhalation hazard classification.
- Standardizing valve outlet selection across supply chains to reduce cross-connection and accidental releases.
Related standards and committees
- Based on ISO 10298:2018; Amendment 1 (2021) integrated as EN ISO 10298:2020/A1:2022 by CEN.
- Developed by ISO/TC 58 (Gas cylinders) and adopted by CEN/TC 23 (Transportable gas cylinders).
Keywords: gas cylinders, toxicity, LC50, cylinder valve outlets, gases and gas mixtures, EN ISO 10298:2020/A1:2022, acute inhalation toxicity, mixture toxicity calculation.
Frequently Asked Questions
SIST EN ISO 10298:2020/A1:2022 is a amendment published by the Slovenian Institute for Standardization (SIST). Its full title is "Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of cylinder valve outlets - Amendment 1 (ISO 10298:2018/Amd 1:2021)". This standard covers: This document lists the best available acute-toxicity data of gases taken from a search of the current literature to allow the classification of gases and gas mixtures for toxicity by inhalation. Scope of amendment Changes to formula in clause 4.3
This document lists the best available acute-toxicity data of gases taken from a search of the current literature to allow the classification of gases and gas mixtures for toxicity by inhalation. Scope of amendment Changes to formula in clause 4.3
SIST EN ISO 10298:2020/A1:2022 is classified under the following ICS (International Classification for Standards) categories: 23.020.35 - Gas cylinders; 71.100.20 - Gases for industrial application. The ICS classification helps identify the subject area and facilitates finding related standards.
SIST EN ISO 10298:2020/A1:2022 has the following relationships with other standards: It is inter standard links to SIST EN ISO 10298:2020. Understanding these relationships helps ensure you are using the most current and applicable version of the standard.
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Standards Content (Sample)
SLOVENSKI STANDARD
01-november-2022
Plinske jeklenke - Plini in zmesi plinov - Določanje strupenosti plinov in njihovih
zmesi za izbiro izhodnega priključka ventila na jeklenki - Dopolnilo A1 (ISO
10298:2018/Amd 1:2021)
Gas cylinders - Gases and gas mixtures - Determination of toxicity for the selection of
cylinder valve outlets - Amendment 1 (ISO 10298:2018/Amd 1:2021)
Gasflaschen - Gase und Gasgemische - Bestimmung der Toxizität zur Auswahl von
Ventilausgängen - Änderung 1 (ISO 10298:2018/Amd 1:2021)
Bouteilles à gaz - Gaz et mélanges de gaz - Détermination de la toxicité pour le choix
des raccords de sortie de robinets - Amendement 1 (ISO 10298:2018/Amd 1:2021)
Ta slovenski standard je istoveten z: EN ISO 10298:2020/A1:2022
ICS:
23.020.35 Plinske jeklenke Gas cylinders
71.100.20 Industrijski plini Gases for industrial
application
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
EN ISO 10298:2020/A1
EUROPEAN STANDARD
NORME EUROPÉENNE
September 2022
EUROPÄISCHE NORM
ICS 71.100.20
English Version
Gas cylinders - Gases and gas mixtures - Determination of
toxicity for the selection of cylinder valve outlets -
Amendment 1 (ISO 10298:2018/Amd 1:2021)
Bouteilles à gaz - Gaz et mélanges de gaz - Gasflaschen - Gase und Gasgemische - Bestimmung der
Détermination de la toxicité pour le choix des raccords Toxizität zur Auswahl von Ventilausgängen - Änderung
de sortie de robinets - Amendement 1 (ISO 1 (ISO 10298:2018/Amd 1:2021)
10298:2018/Amd 1:2021)
This amendment A1 modifies the European Standard EN ISO 10298:2020; it was approved by CEN on 29 August 2022.
CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for inclusion of
this amendment into the relevant national standard without any alteration. Up-to-date lists and bibliographical references
concerning such national standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN
member.
This amendment exists in three official versions (English, French, German). A version in any other language made by translation
under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC Management Centre has the
same status as the official versions.
CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway,
Poland, Portugal, Republic of North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Türkiye and
United Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION
EUROPÄISCHES KOMITEE FÜR NORMUNG
CEN-CENELEC Management Centre: Rue de la Science 23, B-1040 Brussels
© 2022 CEN All rights of exploitation in any form and by any means reserved Ref. No. EN ISO 10298:2020/A1:2022 E
worldwide for CEN national Members.
Contents Page
European foreword . 3
European foreword
The text of ISO 10298:2018/Amd 1:2021 has been prepared by Technical Committee ISO/TC 58 "Gas
cylinders” of the International Organization for Standardization (ISO) and has been taken over as
secretariat of which is held by BSI.
This Amendment to the European Standard EN ISO 10298:2020 shall be given the status of a national
standard, either by publication of an identical text or by endorsement, at the latest by March 2023, and
conflicting national standards shall be withdrawn at the latest by March 2023.
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. CEN shall not be held responsible for identifying any or all such patent rights.
Any feedback and questions on this document should be directed to the users’ national standards body.
A complete listing of these bodies can be found on the CEN website.
According to the CEN-CENELEC Internal Regulations, the national standards organizations of the
following countries are bound to implement this
...
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