prEN ISO 13977-1
(Main)Workplace atmospheres - Assessment of dermal exposure - Part 1: Framework for Dermal exposure assessment (ISO/DIS 13977‑1:2025)
Workplace atmospheres - Assessment of dermal exposure - Part 1: Framework for Dermal exposure assessment (ISO/DIS 13977‑1:2025)
This document describes a systematic approach to assess potential occupational risks related to the dermal exposure to chemical agents at the workplace. This approach provides guidance to identify hazards, exposure routes, exposed body parts and potential consequences of exposure with respect to skin uptake and local skin effects, using qualitative and quantitative approaches.
NOTE There is a relation between skin contamination and inadvertent ingestion.
This document is aimed at occupational hygienists, researchers and other safety professionals to assist recognition of potential dermal exposure and its potential consequences.
Arbeitsplatzatmosphäre - Beurteilung der Hautbelastung - Teil 1: Rahmen zur Beurteilung der Hautbelastung (ISO/DIS 13977‑1:2025)
Atmosphères des lieux de travail - Évaluation de l'exposition cutanée - Partie 1: Cadre pour l'évaluation de l'exposition cutanée (ISO/DIS 13977‑1:2025)
Zrak na delovnem mestu - Ocena dermalne izpostavljenosti - 1. del: Okvirno navodilo za oceno dermalne izpostavljenosti (ISO/DIS 13977-1:2025)
General Information
Standards Content (Sample)
SLOVENSKI STANDARD
01-april-2025
Zrak na delovnem mestu - Ocena dermalne izpostavljenosti - 1. del: Okvirno
navodilo za oceno dermalne izpostavljenosti (ISO/DIS 13977-1:2025)
Workplace atmospheres - Assessment of dermal exposure - Part 1: Framework for
Dermal exposure assessment (ISO/DIS 13977-1:2025)
Arbeitsplatzatmosphäre - Beurteilung der Hautbelastung - Teil 1: Rahmen zur
Beurteilung der Hautbelastung (ISO/DIS 13977-1:2025)
Atmosphères des lieux de travail - Évaluation de l'exposition cutanée - Partie 1: Cadre
pour l'évaluation de l'exposition cutanée (ISO/DIS 13977-1:2025)
Ta slovenski standard je istoveten z: prEN ISO 13977-1
ICS:
13.040.30 Kakovost zraka na delovnem Workplace atmospheres
mestu
13.100 Varnost pri delu. Industrijska Occupational safety.
higiena Industrial hygiene
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
DRAFT
International
Standard
ISO/DIS 13977-1
ISO/TC 146/SC 2
Workplace atmospheres —
Secretariat: ANSI
Assessment of dermal exposure —
Voting begins on:
Part 1: 2025-03-06
Framework for Dermal exposure
Voting terminates on:
2025-05-29
assessment
ICS: 13.100; 13.040.30
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Reference number
ISO/DIS 13977-1:2025(en)
DRAFT
ISO/DIS 13977-1:2025(en)
International
Standard
ISO/DIS 13977-1
ISO/TC 146/SC 2
Workplace atmospheres —
Secretariat: ANSI
Assessment of dermal exposure —
Voting begins on:
Part 1:
Framework for Dermal exposure
Voting terminates on:
assessment
ICS: 13.100; 13.040.30
THIS DOCUMENT IS A DRAFT CIRCULATED
FOR COMMENTS AND APPROVAL. IT
IS THEREFORE SUBJECT TO CHANGE
AND MAY NOT BE REFERRED TO AS AN
INTERNATIONAL STANDARD UNTIL
PUBLISHED AS SUCH.
This document is circulated as received from the committee secretariat.
IN ADDITION TO THEIR EVALUATION AS
BEING ACCEPTABLE FOR INDUSTRIAL,
© ISO 2025
TECHNOLOGICAL, COMMERCIAL AND
USER PURPOSES, DRAFT INTERNATIONAL
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Published in Switzerland Reference number
ISO/DIS 13977-1:2025(en)
ii
ISO/DIS 13977-1:2025(en)
Contents Page
Foreword .iv
Introduction .v
1 Scope . 1
2 Normative references . 1
3 Terms and definitions . 1
4 Schematic overview of the framework for dermal exposure assessment . 3
5 Information gathering . 6
5.1 General .6
5.2 Substance-related information .6
5.3 Population at risk .8
5.4 Workplaces, tasks and / or processes at risk and RMMs in place .8
5.5 Identify similar exposure groups .9
6 Dermal risk assessment . 9
6.1 Dermal hazard assessment .9
6.2 Qualitative dermal exposure assessment .10
6.2.1 Outcome related to local corrosive/irritation effects .10
6.2.2 Outcome related to sensitizing effects .10
6.2.3 Outcome related to local carcinogenic and systemic effects .10
6.3 Quantitative dermal exposure assessment.11
6.3.1 Modelling dermal exposure .11
6.3.2 Measuring dermal exposure .11
7 Dermal risk assessment report .13
7.1 General section in the report . 13
7.2 Qualitative dermal exposure assessment . 13
7.3 Quantitative dermal exposure assessment.14
7.3.1 Modelled dermal exposure assessment .14
7.3.2 Measured dermal exposure assessment .14
8 Evaluation and periodic reassessment .15
Annex A (informative) Conceptual model .16
Annex B (informative) Local and systemic effects related to dermal exposure .18
Annex C (informative) Checklist for visiting workplaces .20
Annex D (informative) Kinney and Fine risk assessment method .24
Annex E (informative) Models and tools .26
Annex F (informative) Measurement of dermal exposure .29
Bibliography .34
iii
ISO/DIS 13977-1:2025(en)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out through
ISO technical committees. Each member body interested in a subject for which a technical committee
has been established has the right to be represented on that committee. International organizations,
governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely
with the International Electrotechnical Commission (IEC) on all matters of electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are described
in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types
of ISO documents should be noted. This document was drafted in accordance with the editorial rules of the
ISO/IEC Directives, Part 2 (see www.iso.org/directives).
Attention is drawn to the possibility that some of the elements of this document may be the subject of patent
rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of any patent
rights identified during the development of the document will be in the Introduction and/or on the ISO list of
patent declarations received (see www.iso.org/patents).
Any trade name used in this document is information given for the convenience of users and does not
constitute an endorsement.
For an explanation on the meaning of ISO specific terms and expressions related to conformity assessment,
as well as information about ISO's adherence to the World Trade Organization (WTO) principles in the
Technical Barriers to Trade (TBT) see the following URL: www.iso.org/iso/foreword.html.
This document was prepared by Technical Committee ISO/TC 146, Subcommittee SC 2, Workplace
atmospheres, in collaboration with the European Committee for Standardization (CEN) Technical Committee
CEN/TC 137, Assessment of workplace exposure to chemical and biological agents, in accordance with the
Agreement on technical cooperation between ISO and CEN (Vienna Agreement).
A list of all parts in the ISO 13977 series can be found on the ISO website.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
iv
ISO/DIS 13977-1:2025(en)
Introduction
Dermal exposure assessment explores the dynamic interaction between environmental contaminants and
the skin. For thousands of chemicals in the workplace, the contribution of the dermal route to total-body
exposure has yet to be determined. Historically, the assessment of occupational exposure has focused
on inhalation of chemical agents. However, evidence from studies investigating the exposure pattern for
different occupational conditions indicates that dermal contact can serve as the primary route of exposure
for many chemical substances.
The penetration and permeation of substances through the skin can cause local and systemic effects,
respectively. Substances in contact with the skin may penetrate the stratum corneum to cause local effects
(irritation, corrosion or sensitization). Substances may also permeate through the skin reaching systemic
circulation leading to systemic effects, using different exposure pathways, namely 1) through sweat glands
and hair follicles, 2) the intercellular route (around the cells), or 3) the intracellular pathway (through the cells).
Observational studies show that the most highly exposed body parts are the hands. However, deposition of
airborne aerosols or direct contact with substances can also contaminate other body parts (e.g. forearms,
chest and forehead). Location of the exposure is
...
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