Cosmetics - Analytical methods - HPLC/UV method for the identification and assay of hydroquinone, ethers of hydroquinone and corticosteroids in skin whitening cosmetic products

This European Standard specifies a HPLC/UV method for the identification and quantification of hydroquinone, 3 ethers of hydroquinone and 4 corticosteroids most frequently found in illegally sold skin whitening cosmetic products: clobetasol propionate, betamethasone dipropionate, fluocinonide and fluocinolone acetonide.
This standard also gives HPLC/UV methods for the identification of 38 corticosteroids that may be found in skin whitening cosmetic products (see Annex D).
This standard is not dedicated to artificial nail products or soaps.

Kosmetische Mittel - Untersuchungsverfahren - HPLC/UV Verfahren für die Identifizierung und Bestimmung von Hydrochinon, Hydrochinonethern und Kortikosteroiden in hautaufhellenden kosmetischen Mitteln

Diese Europäische Norm legt ein HPLC/UV Verfahren zur Identifizierung und Quantifizierung von Hydrochinon, drei Hydrochinon¬ethern und vier Kortikosteroiden fest, die am häufigsten in entgegen den Vorschriften verkauften kosmetischen Mitteln zur Hautaufhellung vorgefunden werden: Clobetasolpro-pionat, Betamethasondipro¬pionat, Fluocinonid und Fluocinolonacetonid.
Diese Norm enthält außerdem HPLC/UV Verfahren zur Identifizierung von 38 Kortikosteroiden, die in Hautaufhellungsprodukten vorkommen können (siehe Anhang D).
Diese Norm ist nicht für künstliche Nagelpflegeprodukte oder Seifen vorgesehen.

Cosmétiques - Méthodes analytiques - Méthode CLHP couplée à la détection UV pour l'identification et l'analyse de l'hydroquinone, de ses éthers et des corticostéroïdes dans les produits cosmétiques éclaircissants de la peau

La présente Norme européenne spécifie une méthode CLHP couplée à la détection UV pour l’identification et la quantification de l’hydroquinone, de trois de ses éthers et de quatre corticostéroïdes principalement présents dans les produits cosmétiques éclaircissants de la peau commercialisés illégalement : le propionate de clobétasol, le dipropionate de bétaméthasone, le fluocinonide et le fluocinolone acétonide.
La présente norme décrit également des méthodes CLHP couplées à la détection UV pour l’identification de trente-huit corticostéroïdes susceptibles d’être présents dans les produits cosmétiques éclaircissants de la peau (voir l’Annexe D).
La présente norme ne concerne pas les produits pour ongles artificiels ou les savons.

Kozmetika - Analizne metode - Metoda HPLC/UV za identifikacijo in določevanje hidrokinona, etrov hidrokinona in kortikosteroidov v kozmetičnih izdelkih za beljenje kože

ICS:   71.100.70
Ta evropski standard določa metodo HPLC/UV za določevanje hidrokinona, 3 etrov hidrokinona in 4 kortikosteroide, ki so najpogosteje prisotni v nezakonito prodajanih kozmetičnih izdelkih za beljenje kože: klobetazol propionat, betametazon dipropionat, fluocinonid in fluocinolon acetonid.
Ta standard podaja tudi metode HPLC/UV za identifikacijo 38 kortikosteroidov, ki jih je mogoče najti v izdelkih za beljenje kože. Ker je kortikosteroide mogoče namerno vnesti v kozmetične izdelke za beljenje kože kljub temu, da je njihova uporaba prepovedana, se lahko na podlagi ugotovljene prisotnosti ene od teh nezakonitih spojin uvede nadzor, ki temelji na raziskavi trga.
Uporaba tega standarda ni predvidena za umetne izdelke za nego nohtov ali mila.

General Information

Status
Published
Publication Date
26-Sep-2017
Withdrawal Date
30-Mar-2018
Technical Committee
Current Stage

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Standards Content (Sample)

2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.Kosmetische Mittel - Untersuchungsverfahren - HPLC/UV Verfahren für die Identifizierung und Bestimmung von Hydrochinon, Hydrochinonethern und Kortikosteroiden in hautaufhellenden kosmetischen MittelnCosmétiques - Méthodes analytiques - Méthode de CLHP couplée à la détection UV pour l'identification et l'analyse de l'hydroquinone, de ses éthers et des corticostéroïdes dans les produits cosmétiques éclaircissants de la peauCosmetics - Analytical methods - HPLC/UV method for the identification and assay of hydroquinone, ethers of hydroquinone and corticosteroids in skin whitening cosmetic products71.100.70SULSRPRþNLCosmetics. ToiletriesICS:Ta slovenski standard je istoveten z:EN 16956:2017SIST EN 16956:2017en,fr,de01-november-2017SIST EN 16956:2017SLOVENSKI
STANDARD



SIST EN 16956:2017



EUROPEAN STANDARD NORME EUROPÉENNE EUROPÄISCHE NORM
EN 16956
September
t r s y ICS
y sä s r rä y r English Version
Cosmetics æ Analytical methoidentification and assay of hydroquinoneá ethers of hydroquinone and corticosteroids in skin whitening cosmetic products Cosmétiques æ Méthodes analytiques æ Méthode de CLHP couplée à la détection UV pour l 5identification et l 5analyse de l 5hydroquinoneá de ses éthers et des corticostéroïdes dans les produits cosmétiques éclaircissants de la peau
Kosmetische Mittel æ Untersuchungsverfahren æ Bestimmung von Hydrochinoná Hydrochinonethern und Kortikosteroiden in hautaufhellenden kosmetischen Mitteln This European Standard was approved by CEN on
s { June
t r s yä
egulations which stipulate the conditions for giving this European Standard the status of a national standard without any alterationä Upætoædate lists and bibliographical references concerning such national standards may be obtained on application to the CENæCENELEC Management Centre or to any CEN memberä
translation under the responsibility of a CEN member into its own language and notified to the CENæCENELEC Management Centre has the same status as the official versionsä
CEN members are the national standards bodies of Austriaá Belgiumá Bulgariaá Croatiaá Cyprusá Czech Republicá Denmarká Estoniaá Finlandá Former Yugoslav Republic of Macedoniaá Franceá Germanyá Greeceá Hungaryá Icelandá Irelandá Italyá Latviaá Lithuaniaá Luxembourgá Maltaá Netherlandsá Norwayá Polandá Portugalá Romaniaá Serbiaá Slovakiaá Sloveniaá Spainá Swedená Switzerlandá Turkey and United Kingdomä
EUROPEAN COMMITTEE FOR STANDARDIZATION COMITÉ EUROPÉEN DE NORMALISATION EUROPÄISCHES KOMITEE FÜR NORMUNG
CEN-CENELEC Management Centre:
Avenue Marnix 17,
B-1000 Brussels
9
t r s y CEN All rights of exploitation in any form and by any means reserved worldwide for CEN national Membersä Refä Noä EN
s x { w xã t r s y ESIST EN 16956:2017



EN 16956:2017 (E) 2
Contents Page European foreword . 3 Introduction . 4 1 Scope . 5 2 Principle . 5 3 Reagents . 5 4 Apparatus and equipment . 8 5 Procedure. 9 5.1 Sample preparation . 9 5.2 Liquid chromatography measurement conditions . 9 5.3 Detection . 10 6 Evaluation . 10 6.1 Identification . 10 6.2 Quantitative determination .
...

SLOVENSKI STANDARD
oSIST prEN 16956:2016
01-februar-2016
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Cosmetics - Analytical methods - HPLC/UV method for the identification and assay of
hydroquinone, ethers of hydroquinone and corticosteroids in skin whitening cosmetic
products
Kosmetische Mittel - Untersuchungsverfahren - HPLC/UV Verfahren für die
Identifizierung und Bestimmung von Hydrochinon, Hydrochinonethern und
Kortikosteroide in hautaufhellenden kosmetischen Mitteln
Ta slovenski standard je istoveten z: prEN 16956
ICS:
71.100.70 .R]PHWLND7RDOHWQL Cosmetics. Toiletries
SULSRPRþNL
oSIST prEN 16956:2016 en,fr,de
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

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oSIST prEN 16956:2016

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oSIST prEN 16956:2016


DRAFT
EUROPEAN STANDARD
prEN 16956
NORME EUROPÉENNE

EUROPÄISCHE NORM

January 2016
ICS 71.100.70
English Version

Cosmetics - Analytical methods - HPLC/UV method for the
identification and assay of hydroquinone, ethers of
hydroquinone and corticosteroids in skin whitening
cosmetic products
 Kosmetische Mittel - Untersuchungsverfahren -
HPLC/UV Verfahren für die Identifizierung und
Bestimmung von Hydrochinon, Hydrochinonethern
und Kortikosteroide in hautaufhellenden kosmetischen
Mitteln
This draft European Standard is submitted to CEN members for enquiry. It has been drawn up by the Technical Committee
CEN/TC 392.

If this draft becomes a European Standard, CEN members are bound to comply with the CEN/CENELEC Internal Regulations
which stipulate the conditions for giving this European Standard the status of a national standard without any alteration.

This draft European Standard was established by CEN in three official versions (English, French, German). A version in any other
language made by translation under the responsibility of a CEN member into its own language and notified to the CEN-CENELEC
Management Centre has the same status as the official versions.

CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania,
Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and
United Kingdom.

Recipients of this draft are invited to submit, with their comments, notification of any relevant patent rights of which they are
aware and to provide supporting documentation.

Warning : This document is not a European Standard. It is distributed for review and comments. It is subject to change without
notice and shall not be referred to as a European Standard.


EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION

EUROPÄISCHES KOMITEE FÜR NORMUNG

CEN-CENELEC Management Centre: Avenue Marnix 17, B-1000 Brussels
© 2016 CEN All rights of exploitation in any form and by any means reserved Ref. No. prEN 16956:2016 E
worldwide for CEN national Members.

---------------------- Page: 3 ----------------------
oSIST prEN 16956:2016
prEN 16956:2016 (E)
Contents Page
European foreword . 3
Introduction . 4
1 Scope . 5
2 Principles . 5
2.1 Identification and quantification of hydroquinone, 3 ethers of hydroquinone and 4
most frequently found corticosteroids . 5
2.2 Screening methods for the identification of hydroquinone, 3 ethers of hydroquinone
and 38 corticosteroids. 5
3 Reagents . 5
4 Apparatus and equipment . 10
5 Procedure.
...

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