FprEN ISO 10991
(Main)Microfluidics - Vocabulary (ISO/DIS 10991:2022)
Microfluidics - Vocabulary (ISO/DIS 10991:2022)
Mikrofluidik - Begriffe (ISO/FDIS 10991:2023)
Dieses Dokument legt Begriffe für die Mikroverfahrenstechnik und Mikrofluidik fest, die in der medizinischen und veterinärmedizinischen Diagnostik, Chemie, Landwirtschaft, Pharmazie, Biotechnologie und Agrar-Lebensmittelindustrie sowie in anderen Anwendungsbereichen verwendet werden.
Microfluidique - Vocabulaire (ISO/DIS 10991:2022)
Mikrofluidika - Slovar (ISO/DIS 10991:2022)
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Standards Content (Sample)
SLOVENSKI STANDARD
oSIST prEN ISO 10991:2022
01-september-2022
Mikrofluidika - Slovar (ISO/DIS 10991:2022)
Microfluidics - Vocabulary (ISO/DIS 10991:2022)
Mikrofluidik – Begriffe (ISO/DIS 10991:2022)
Microfluidique - Vocabulaire (ISO/DIS 10991:2022)
Ta slovenski standard je istoveten z: prEN ISO 10991
ICS:
01.040.71 Kemijska tehnologija Chemical technology
(Slovarji) (Vocabularies)
71.020 Proizvodnja v kemijski Production in the chemical
industriji industry
oSIST prEN ISO 10991:2022 en,fr,de
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
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oSIST prEN ISO 10991:2022
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oSIST prEN ISO 10991:2022
DRAFT INTERNATIONAL STANDARD
ISO/DIS 10991
ISO/TC 48 Secretariat: DIN
Voting begins on: Voting terminates on:
2022-07-18 2022-10-10
Microfluidics — Vocabulary
ICS: 01.040.71; 71.040.10
This document is circulated as received from the committee secretariat.
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PROVIDE SUPPORTING DOCUMENTATION. © ISO 2022
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
DRAFT INTERNATIONAL STANDARD
ISO/DIS 10991
ISO/TC 48 Secretariat: DIN
Voting begins on: Voting terminates on:
Microfluidics — Vocabulary
ICS: 01.040.71; 71.040.10
This document is circulated as received from the committee secretariat.
COPYRIGHT PROTECTED DOCUMENT
THIS DOCUMENT IS A DRAFT CIRCULATED
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© ISO 2022
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NOT BE REFERRED TO AS AN INTERNATIONAL
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NATIONAL REGULATIONS.
Website: www.iso.org ISO/DIS 10991:2022(E)
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PROVIDE SUPPORTING DOCUMENTATION. © ISO 2022
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
Contents Page
Foreword .iv
1 Scope .1
2 Normative references .1
3 Terms and definitions .1
3.1 General terms, relevant to microfluidics . 1
4 General terms in microfluidics .2
5 Microfluidic flow related terms .3
6 Microfluidic interfacing related terms .7
7 Modularity related terms .10
Bibliography .14
Index .15
iii
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
Foreword
ISO (the International Organization for Standardization) is a worldwide federation of national standards
bodies (ISO member bodies). The work of preparing International Standards is normally carried out
through ISO technical committees. Each member body interested in a subject for which a technical
committee has been established has the right to be represented on that committee. International
organizations, governmental and non-governmental, in liaison with ISO, also take part in the work.
ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of
electrotechnical standardization.
The procedures used to develop this document and those intended for its further maintenance are
described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the
different types of ISO documents should be noted. This document was drafted in accordance with the
editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives).
Attention is drawn to the possibility that some of the elements of this document may be the subject of
patent rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of
any patent rights identified during the development of the document will be in the Introduction and/or
on the ISO list of patent declarations received (see www.iso.org/patents).
Any trade name used in this document is information given for the convenience of users and does not
constitute an endorsement.
For an explanation of the voluntary nature of standards, the meaning of ISO specific terms and
expressions related to conformity assessment, as well as information about ISO's adherence to
the World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT), see
www.iso.org/iso/foreword.html.
This document was prepared by Technical ISO/TC 48, Laboratory equipment.
This second edition cancels and replaces the first edition (ISO 10991:2009), which has been technically
revised.
The main changes compared to the previous edition are as follows:
— change of the title: "Microfluidics — Vocabulary" compared to "Micro process engineering —
Vocabulary";
— due to the massive uptake of microfluidic technology in many areas, several terms have been added.
Any feedback or questions on this document should be directed to the user’s national standards body. A
complete listing of these bodies can be found at www.iso.org/members.html.
iv
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oSIST prEN ISO 10991:2022
DRAFT INTERNATIONAL STANDARD ISO/DIS 10991:2022(E)
Microfluidics — Vocabulary
1 Scope
This document gives terms and definitions for micro process engineering and microfluidics applied
in medical and veterinary diagnostics, chemistry, agriculture, pharmacy, biotechnology and agrifood
industry and other application areas.
2 Normative references
There are no normative references in this document.
3 Terms and definitions
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
3.1 General terms, relevant to microfluidics
3.1.1
biocompatibility
special quality of some materials allowing them to come into contact with biological materials without
changing the materials’ bioactivity
3.1.2
biomarker
biological molecule found in blood, other body fluids or tissues that is used to identify a disease or
monitor the progression of a disease
3.1.3
classification
method of sorting into categories
[SOURCE: ISO 22935-1:2009, 3.7]
3.1.4
end-user
person or persons who will ultimately be using the system (3.1.15) for its intended purpose
[SOURCE: ISO/IEC 19770-5:2015, 3.13, modified – Note 1 to entry has been removed.]
3.1.5
hydrophilic
property of material of molecule characterised by affinity to water established by hydrogen bonding
3.1.6
hydrophobic
property of a surface or molecule that is repelled from a mass of water
[SOURCE: Semi MS006, Guide for design and materials for interfacing microfluidic systems]
1
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ISO/DIS 10991:2022(E)
3.1.7
interested party
stakeholders
person or organization that can affect, be affected by or perceive themselves to be affected by a decision
or activity
Note 1 to entry: For system see 3.1.15.
[SOURCE: ISO 28007-1:2015, 3.6, modified – Note 1 to entry has been removed.]
3.1.8
interoperability
property permitting diverse systems or components to work together for a specified purpose
[SOURCE: IEC 80001-1:2010, definition 2.11]
3.1.9
macroscale
dimensions of 0.1 millimetres or greater
[SOURCE: Semi MS003, Terminology for MEMS technology]
3.1.10
microfluidics
manipulation of fluids that are confined in a small volume with at least one dimension smaller than
1 mm
3.1.11
microscale
-3 -6
scale of dimensions between 0.1 × 10 meters to 0.1 × 10 meters
3.1.12
miniaturization
making things on a smaller scale
3.1.13
plug and play
denoting or relating to software or devices that are intended to work perfectly when first used
or connected, without reconfiguration or adjustment by the user and thereby enable automatic
configuration
3.1.14
wettability
ability of a liquid to spread on a specific solid surface
[SOURCE: ISO 472:2013, 2.1607, modified – wording “(such as an adhesive)” delated and Note 1 to entry
has been removed.]
3.1.15
system
sub-system
group of interacting microfluidic, optical, mechanical or electrical components
4 General terms in microfluidics
4.1.1
actuating resolution
lowest variation of a physical parameter that can be operated by a system (3.1.15)
2
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
4.1.2
capacity
flow rate through a pump at its designed conditions
4.1.3
centrifugal microfluidics
sub category of microfluidics (3.1.10) utilizing rotation
Note 1 to entry: The fluid flow is mainly controlled by centrifugal-, Euler- and Coriolis- forces.
4.1.4
closed system
system (3.1.15) that uses preloaded manufacturer-specific reagents only
4.1.5
digital microfluidics
sub category of microfluidics (3.1.10) where discrete quantities of liquid are manipulated individually
over a surface
4.1.6
droplet microfluidics
sub category of microfluidics (3.1.10) manipulating discrete quantities of liquid in a continues flow
4.1.7
lab-on-a-chip
LoC
highly integrated, microfluidic system (3.1.15) providing analytical or diagnostic functions
4.1.8
open system
system (3.1.15) that requires external supply of reagents
Note 1 to entry: Such an open system (3.1.15) needs microfluidic connection(s).
4.1.9
resolution
smallest change in a quantity being measured that causes a perceptible change in corresponding
measurement indication
4.1.10
sensing resolution
lowest variation of a physical parameter that can be detected by a sensor
5 Microfluidic flow related terms
5.1.1
actual flow rate
volumetric flow rate of a gas changed to "standardised" conditions of temperature and pressure
5.1.2
capillary force
capillary action
flowing of liquid through a device without external actuators but only by surface tension and adhesive
force between liquid and the wetted material
5.1.3
compliance of a fluidic system
increase of a fluidic system’s internal volume under the effect of pressure
Note 1 to entry: The compliance of a fluidic system (3.1.15) is expressed in volume units per pressure units.
3
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5.1.4
dead-volume
portion of the internal volume of a system (3.1.15) that is not part of a continuous flow-path
Note 1 to entry: In this context dead signifies unmoving, stagnant, or un-swept, and expressed in volume units.
5.1.5
fall time
time required for a flow to change from a specified high value to a specified low value
Note 1 to entry: Typically, these values are 10% and 90% of the step height. The fall time is expressed in time
units.
5.1.6
final steady state value
average value of the actual flow rate, after the effects of the input transient have faded to a value equal
to or below the intrinsic drift and noise
Note 1 to entry: The final steady state flow rate value is expressed in volume units or mass unites over time units.
[SOURCE: SEMI E17-0600, Guideline for Mass Flow Controller Transient Characterizations Tests, modified –
“flow rate” and mass units added in the Note 1 to entry.]
5.1.7
hold-up volume
volume of fluid required to fill a device before flow is observed at point of interest or at the outlet
3
Note 1 to entry: The hold-up volume is expressed in volume units such as mm or microliter.
[SOURCE: Semi MS003, Terminology for MEMS technology, modified – “units” added in the Note 1 to
entry.]
5.1.8
hydrodynamic resistance
ratio of pressure drop over flow rate for a certain component or system (3.1.15)
Note 1 to entry: The hydrodynamic resistance is expressed as pressure units per flow rate units.
5.1.9
hydrostatic pressure
pressure that is exerted by a fluid at rest contained within a system (3.1.15) due to the force of gravity
Note 1 to entry: The hydrostatic pressure is expressed in pressure units.
5.1.10
internal volume
maximal total available volume comprised within a fluidic component, device or system (3.1.15) under
normal atmospheric pressure
3
Note 1 to entry: The internal volume is expressed in volume units such as mm or microliter.
5.1.11
mass flow rate
mass of fluid which passes per unit of time
Note 1 to entry: The mass flow rate is expressed in mass units per time units.
5.1.12
micro pump
miniaturized liquid or gas pumping equipment with capacity (4.1.2) of lower than millilitre per minute
flow rate
4
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oSIST prEN ISO 10991:2022
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5.1.13
minimal actuating pressure
input pressure required to start moving a fluid through the fluidic component. Expressed in pressure
units
5.1.14
pressure drop
difference of pressure between two positions in the flow path. Expressed in pressure units
5.1.15
reaction time
time interval between the moment of set point step change and the moment at which the flow reaches
x% of is intended value rise or fall
Note 1 to entry: Typically, x = 10. The reaction time is expressed in time units.
Note 2 to entry: See also Figure 1.
5.1.16
relative flow stability
coefficient of variation
standard deviation of the flow rate divided by the average flow rate. Expressed as a percentage
5.1.17
response time
time interval between the moment of set point step change and the moment at which the flow reaches
y% of is intended value of rise or fall
Note 1 to entry: Typically, y = 90. The response time is expressed in time units.
Note 2 to entry: See also Figure 1.
5.1.18
rise time
time required for a flow to change from a specified low value to a specified high value
Note 1 to entry: Typically, these values are 10% and 90% of the step height. The rise
...
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