prEN ISO 10991

Microfluidics - Vocabulary (ISO/DIS 10991:2022)

Mikrofluidik – Begriffe (ISO/DIS 10991:2022)

Microfluidique - Vocabulaire (ISO/DIS 10991:2022)

Mikrofluidika - Slovar (ISO/DIS 10991:2022)

General Information

• Status: Not Published
• Publication Date: 12-Aug-2024
• ICS: 01.040.71 - Chemical technology (Vocabularies)
• ICS: 71.020 - Production in the chemical industry
• ICS: 71.040.10 - Chemical laboratories. Laboratory equipment
• Technical Committee: CEN/TC 332 - Laboratory equipment
• Drafting Committee: CEN/TC 332 - Laboratory equipment
• Current Stage: 4599 - Dispatch of FV draft to CMC - Finalization for Vote
• Start Date: 12-Apr-2023
• Completion Date: 12-Apr-2023
• Ref Project: oSIST prEN ISO 10991:2022 - Microfluidics - Vocabulary (ISO/DIS 10991:2022)

Relations

• Revises: EN ISO 10991:2009 - Micro process engineering - Vocabulary (ISO 10991:2009)
• Effective Date: 19-Jan-2023

Standards Content (Sample)

SLOVENSKI STANDARD
oSIST prEN ISO 10991:2022
01-september-2022
Mikrofluidika - Slovar (ISO/DIS 10991:2022)
Microfluidics - Vocabulary (ISO/DIS 10991:2022)
Mikrofluidik – Begriffe (ISO/DIS 10991:2022)
Microfluidique - Vocabulaire (ISO/DIS 10991:2022)
Ta slovenski standard je istoveten z: prEN ISO 10991
ICS:
01.040.71 Kemijska tehnologija Chemical technology
(Slovarji) (Vocabularies)
71.020 Proizvodnja v kemijski Production in the chemical
industriji industry
oSIST prEN ISO 10991:2022 en,fr,de

2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.

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oSIST prEN ISO 10991:2022
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oSIST prEN ISO 10991:2022
DRAFT INTERNATIONAL STANDARD
ISO/DIS 10991
ISO/TC 48 Secretariat: DIN
Voting begins on: Voting terminates on:
2022-07-18 2022-10-10
Microfluidics — Vocabulary
ICS: 01.040.71; 71.040.10
This document is circulated as received from the committee secretariat.
THIS DOCUMENT IS A DRAFT CIRCULATED
FOR COMMENT AND APPROVAL. IT IS
ISO/CEN PARALLEL PROCESSING
THEREFORE SUBJECT TO CHANGE AND MAY
NOT BE REFERRED TO AS AN INTERNATIONAL
STANDARD UNTIL PUBLISHED AS SUCH.
IN ADDITION TO THEIR EVALUATION AS
BEING ACCEPTABLE FOR INDUSTRIAL,
TECHNOLOGICAL, COMMERCIAL AND
USER PURPOSES, DRAFT INTERNATIONAL
STANDARDS MAY ON OCCASION HAVE TO
BE CONSIDERED IN THE LIGHT OF THEIR
POTENTIAL TO BECOME STANDARDS TO
WHICH REFERENCE MAY BE MADE IN
Reference number
NATIONAL REGULATIONS.
ISO/DIS 10991:2022(E)
RECIPIENTS OF THIS DRAFT ARE INVITED
TO SUBMIT, WITH THEIR COMMENTS,
NOTIFICATION OF ANY RELEVANT PATENT
RIGHTS OF WHICH THEY ARE AWARE AND TO
PROVIDE SUPPORTING DOCUMENTATION. © ISO 2022
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
DRAFT INTERNATIONAL STANDARD
ISO/DIS 10991
ISO/TC 48 Secretariat: DIN
Voting begins on: Voting terminates on:
Microfluidics — Vocabulary
ICS: 01.040.71; 71.040.10
This document is circulated as received from the committee secretariat.
COPYRIGHT PROTECTED DOCUMENT
THIS DOCUMENT IS A DRAFT CIRCULATED
FOR COMMENT AND APPROVAL. IT IS
© ISO 2022
ISO/CEN PARALLEL PROCESSING
THEREFORE SUBJECT TO CHANGE AND MAY

All rights reserved. Unless otherwise specified, or required in the context of its implementation, no part of this publication may

NOT BE REFERRED TO AS AN INTERNATIONAL

be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on STANDARD UNTIL PUBLISHED AS SUCH.

the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below

IN ADDITION TO THEIR EVALUATION AS

or ISO’s member body in the country of the requester. BEING ACCEPTABLE FOR INDUSTRIAL,

TECHNOLOGICAL, COMMERCIAL AND
ISO copyright office
USER PURPOSES, DRAFT INTERNATIONAL
CP 401 • Ch. de Blandonnet 8
STANDARDS MAY ON OCCASION HAVE TO
BE CONSIDERED IN THE LIGHT OF THEIR
CH-1214 Vernier, Geneva
POTENTIAL TO BECOME STANDARDS TO
Phone: [phone]
WHICH REFERENCE MAY BE MADE IN
Reference number
Email: [e-mail]
NATIONAL REGULATIONS.
Website: www.iso.org ISO/DIS 10991:2022(E)
RECIPIENTS OF THIS DRAFT ARE INVITED
Published in Switzerland
TO SUBMIT, WITH THEIR COMMENTS,
NOTIFICATION OF ANY RELEVANT PATENT
RIGHTS OF WHICH THEY ARE AWARE AND TO
© ISO 2022 – All rights reserved
PROVIDE SUPPORTING DOCUMENTATION. © ISO 2022
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
Contents  Page

Foreword ........................................................................................................................................................................................................................................iv

1  Scope .................................................................................................................................................................................................................................1

2  Normative references .....................................................................................................................................................................................1

3  Terms and definitions ....................................................................................................................................................................................1

3.1 General terms, relevant to microfluidics ........................................................................................................................ 1

4  General terms in microfluidics ............................................................................................................................................................2

5  Microfluidic flow related terms ...........................................................................................................................................................3

6  Microfluidic interfacing related terms ........................................................................................................................................7

7  Modularity related terms ........................................................................................................................................................................10

Bibliography .............................................................................................................................................................................................................................14

Index .................................................................................................................................................................................................................................................15

iii
© ISO 2022 – All rights reserved
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oSIST prEN ISO 10991:2022
ISO/DIS 10991:2022(E)
Foreword

ISO (the International Organization for Standardization) is a worldwide federation of national standards

bodies (ISO member bodies). The work of preparing International Standards is normally carried out

through ISO technical committees. Each member body interested in a subject for which a technical

committee has been established has the right to be represented on that committee. International

organizations, governmental and non-governmental, in liaison with ISO, also take part in the work.

ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of

electrotechnical standardization.

The procedures used to develop this document and those intended for its further maintenance are

described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the

different types of ISO documents should be noted. This document was drafted in accordance with the

editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives).

Attention is drawn to the possibility that some of the elements of this document may be the subject of

patent rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of

any patent rights identified during the development of the document will be in the Introduction and/or

on the ISO list of patent declarations received (see www.iso.org/patents).

Any trade name used in this document is information given for the convenience of users and does not

constitute an endorsement.

For an explanation of the voluntary nature of standards, the meaning of ISO specific terms and

expressions related to conformity assessment, as well as information about ISO's adherence to

the World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT), see

www.iso.org/iso/foreword.html.
This document was prepared by Technical ISO/TC 48, Laboratory equipment.

This second edition cancels and replaces the first edition (ISO 10991:2009), which has been technically

revised.
The main changes compared to the previous edition are as follows:

— change of the title: "Microfluidics — Vocabulary" compared to "Micro process engineering —

Vocabulary";

— due to the massive uptake of microfluidic technology in many areas, several terms have been added.

Any feedback or questions on this document should be directed to the user’s national standards body. A

complete listing of these bodies can be found at www.iso.org/members.html.
  © ISO 2022 – All rights reserved
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oSIST prEN ISO 10991:2022
DRAFT INTERNATIONAL STANDARD ISO/DIS 10991:2022(E)
Microfluidics — Vocabulary
1  Scope

This document gives terms and definitions for micro process engineering and microfluidics applied

in medical and veterinary diagnostics, chemistry, agriculture, pharmacy, biotechnology and agrifood

industry and other application areas.
2  Normative references
There are no normative references in this document.
3  Terms and definitions

ISO and IEC maintain terminological databases for use in standardization at the following addresses:

— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
3.1  General terms, relevant to microfluidics
3.1.1
biocompatibility

special quality of some materials allowing them to come into contact with biological materials without

changing the materials’ bioactivity
3.1.2
biomarker

biological molecule found in blood, other body fluids or tissues that is used to identify a disease or

monitor the progression of a disease
3.1.3
classification
method of sorting into categories
[SOURCE: ISO 22935-1:2009, 3.7]
3.1.4
end-user

person or persons who will ultimately be using the system (3.1.15) for its intended purpose

[SOURCE: ISO/IEC 19770-5:2015, 3.13, modified – Note 1 to entry has been removed.]

3.1.5
hydrophilic

property of material of molecule characterised by affinity to water established by hydrogen bonding

3.1.6
hydrophobic
property of a surface or molecule that is repelled from a mass of water

[SOURCE: Semi MS006, Guide for design and materials for interfacing microfluidic systems]

© ISO 2022 – All rights reserved
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ISO/DIS 10991:2022(E)
3.1.7
interested party
stakeholders

person or organization that can affect, be affected by or perceive themselves to be affected by a decision

or activity
Note 1 to entry: For system see 3.1.15.
[SOURCE: ISO 28007-1:2015, 3.6, modified – Note 1 to entry has been removed.]
3.1.8
interoperability

property permitting diverse systems or components to work together for a specified purpose

[SOURCE: IEC 80001-1:2010, definition 2.11]
3.1.9
macroscale
dimensions of 0.1 millimetres or greater
[SOURCE: Semi MS003, Terminology for MEMS technology]
3.1.10
microfluidics

manipulation of fluids that are confined in a small volume with at least one dimension smaller than

1 mm
3.1.11
microscale
-3 -6
scale of dimensions between 0.1 × 10 meters to 0.1 × 10 meters
3.1.12
miniaturization
making things on a smaller scale
3.1.13
plug and play

denoting or relating to software or devices that are intended to work perfectly when first used

or connected, without reconfiguration or adjustment by the user and thereby enable automatic

configuration
3.1.14
wettability
ability of a liquid to spread on a specific solid surface

[SOURCE: ISO 472:2013, 2.1607, modified – wording “(such as an adhesive)” delated and Note 1 to entry

has been removed.]
3.1.15
system
sub-system
group of interacting microfluidic, optical, mechanical or electrical components
4  General terms in microfluidics
4.1.1
actuating resolution

lowest variation of a physical parameter that can be operated by a system (3.1.15)

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4.1.2
capacity
flow rate through a pump at its designed conditions
4.1.3
centrifugal microfluidics
sub category of microfluidics (3.1.10) utilizing rotation

Note 1 to entry: The fluid flow is mainly controlled by centrifugal-, Euler- and Coriolis- forces.

4.1.4
closed system
system (3.1.15) that uses preloaded manufacturer-specific reagents only
4.1.5
digital microfluidics

sub category of microfluidics (3.1.10) where discrete quantities of liquid are manipulated individually

over a surface
4.1.6
droplet microfluidics

sub category of microfluidics (3.1.10) manipulating discrete quantities of liquid in a continues flow

4.1.7
lab-on-a-chip
LoC

highly integrated, microfluidic system (3.1.15) providing analytical or diagnostic functions

4.1.8
open system
system (3.1.15) that requires external supply of reagents
Note 1 to entry: Such an open system (3.1.15) needs microfluidic connection(s).
4.1.9
resolution

smallest change in a quantity being measured that causes a perceptible change in corresponding

measurement indication
4.1.10
sensing resolution
lowest variation of a physical parameter that can be detected by a sensor
5  Microfluidic flow related terms
5.1.1
actual flow rate

volumetric flow rate of a gas changed to "standardised" conditions of temperature and pressure

5.1.2
capillary force
capillary action

flowing of liquid through a device without external actuators but only by surface tension and adhesive

force between liquid and the wetted material
5.1.3
compliance of a fluidic system
increase of a fluidic system’s internal volume under the effect of pressure

Note 1 to entry: The compliance of a fluidic system (3.1.15) is expressed in volume units per pressure units.

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ISO/DIS 10991:2022(E)
5.1.4
dead-volume

portion of the internal volume of a system (3.1.15) that is not part of a continuous flow-path

Note 1 to entry: In this context dead signifies unmoving, stagnant, or un-swept, and expressed in volume units.

5.1.5
fall time

time required for a flow to change from a specified high value to a specified low value

Note 1 to entry: Typically, these values are 10% and 90% of the step height. The fall time is expressed in time

units.
5.1.6
final steady state value

average value of the actual flow rate, after the effects of the input transient have faded to a value equal

to or below the intrinsic drift and noise

Note 1 to entry: The final steady state flow rate value is expressed in volume units or mass unites over time units.

[SOURCE: SEMI E17-0600, Guideline for Mass Flow Controller Transient Characterizations Tests, modified –

“flow rate” and mass units added in the Note 1 to entry.]
5.1.7
hold-up volume

volume of fluid required to fill a device before flow is observed at point of interest or at the outlet

Note 1 to entry: The hold-up volume is expressed in volume units such as mm or microliter.

[SOURCE: Semi MS003, Terminology for MEMS technology, modified – “units” added in the Note 1 to

entry.]
5.1.8
hydrodynamic resistance
ratio of pressure drop over flow rate for a certain component or system (3.1.15)

Note 1 to entry: The hydrodynamic resistance is expressed as pressure units per flow rate units.

5.1.9
hydrostatic pressure

pressure that is exerted by a fluid at rest contained within a system (3.1.15) due to the force of gravity

Note 1 to entry: The hydrostatic pressure is expressed in pressure units.
5.1.10
internal volume

maximal total available volume comprised within a fluidic component, device or system (3.1.15) under

normal atmospheric pressure

Note 1 to entry: The internal volume is expressed in volume units such as mm or microliter.

5.1.11
mass flow rate
mass of fluid which passes per unit of time
Note 1 to entry: The mass flow rate is expressed in mass units per time units.
5.1.12
micro pump

miniaturized liquid or gas pumping equipment with capacity (4.1.2) of lower than millilitre per minute

flow rate
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5.1.13
minimal actuating pressure

input pressure required to start moving a fluid through the fluidic component. Expressed in pressure

units
5.1.14
pressure drop

difference of pressure between two positions in the flow path. Expressed in pressure units

5.1.15
reaction time

time interval between the moment of set point step change and the moment at which the flow reaches

x% of is intended value rise or fall

Note 1 to entry: Typically, x = 10. The reaction time is expressed in time units.

Note 2 to entry: See also Figure 1.
5.1.16
relative flow stability
coefficient of variation

standard deviation of the flow rate divided by the average flow rate. Expressed as a percentage

5.1.17
response time

time interval between the moment of set point step change and the moment at which the flow reaches

y% of is intended value of rise or fall

Note 1 to entry: Typically, y = 90. The response time is expressed in time units.

Note 2 to entry: See also Figure 1.
5.1.18
rise time

time required for a flow to change from a specified low value to a specified high value

Note 1 to entry: Typically, these values are 10% and 90% of the step height. The rise

...