SIST-TP CEN/TR 16468:2013
(Main)Food analysis - Determination of pesticide residues by GC-MS - Retention times, mass spectrometric parameters and detector response information
Food analysis - Determination of pesticide residues by GC-MS - Retention times, mass spectrometric parameters and detector response information
This Technical Report lists mass spectrometric parameters which are useful for the application of European Standards for the determination of pesticide residues in foods that use GC-MS, such as the following standards: - EN 1528 (all parts), Fatty food - Determination of pesticides and polychlorinated biphenyls (PCBs); - EN 12393 (all parts), Foods of plant origin - Multiresidue methods for the gas chromatographic determination of pesticide residues; - EN 15662, Foods of plant origin - Determination of pesticide residues using GC-MS and/or LC-MS/MS following acetonitrile extraction/partitioning and clean-up by dispersive SPE - QuEChERS-method. To facilitate the determination of pesticides and/or metabolites using GC-MS, Table 1 specifies the diagnostic ions suitable for quantification, which can be used.
Lebensmitteluntersuchung - Bestimmung von Pestizidrückständen mit GC-MS - Retentionszeiten, Parameter für die Massenspektrometrie und Detektionsempfindlichkeit
Analyse des produits alimentaires - Détermination des résidus de pesticides par CG-SM - Temps de rétention, paramètres de spectrométrie de masse et information sur la réponse des détecteurs
Le présent rapport technique répertorie des paramètres de spectrométrie de masse qui sont utiles pour l'application de normes européennes relatives à la détermination de résidus de pesticides dans les produits alimentaires par CG-SM, telles que les normes suivantes :
- EN 1528 (toutes les parties), Aliments gras — Dosage des pesticides et des polychlorobiphényles (PCB).
- EN 12393 (toutes les parties), Aliments d'origine végétale — Méthodes multirésidus de détermination par chromatographie en phase gazeuse de résidus de pesticides.
- EN 15662, Aliments d'origine végétale — Méthode de détermination des résidus de pesticides par CG-SM et CL-SM/SM suite à l’extraction/partition à l'acétonitrile et à la purification sur EPS dispersés — Méthode QuEChERS.
Pour faciliter la détermination des pesticides et/ou des métabolites par CG-SM, le tableau 1 spécifie les ions diagnostiques appropriés pour la quantification, qu'il est possible d'utiliser.
Analiza živil - Določevanje ostankov pesticidov z uporabo GC-MS - Retenzijski časi, parametri masne spektrometrije in informacije odziva detektorja
To tehnično poročilo navaja parametre masne spektrometrije, ki so uporabni za evropske standarde za določevanje ostankov pesticidov v živilih z uporabo GC-MS, kot so naslednji standardi: – EN 1528 (vsi deli), Živila, ki vsebujejo maščobe – Določevanje pesticidov in polikloriranih bifenilov (PCB); – EN 12393 (vsi deli), Živila brez maščob – Multirezidualne metode za določevanje ostankov pesticidov s plinsko kromatografijo; – EN 15662, Hrana rastlinskega izvora – Določanje ostankov pesticidov z uporabo GC-MS in/ali LC-MS(/MS) po delitvi in izpiranju acetonitrila z disperzivno SPE – Metoda QuEChERS. Za lažje določevanje pesticidov in/ali metabolitov z uporabo GC-MS so v preglednici 1 navedeni diagnostični ioni, primerni za kvantifikacijo, ki jih je mogoče uporabiti.
General Information
Standards Content (Sample)
SLOVENSKI STANDARD
SIST-TP CEN/TR 16468:2013
01-junij-2013
$QDOL]DåLYLO'RORþHYDQMHRVWDQNRYSHVWLFLGRY]XSRUDER*&065HWHQ]LMVNL
þDVLSDUDPHWULPDVQHVSHNWURPHWULMHLQLQIRUPDFLMHRG]LYDGHWHNWRUMD
Food analysis - Determination of pesticide residues by GC-MS - Retention times, mass
spectrometric parameters and detector response information
Lebensmitteluntersuchung - Bestimmung von Pestizidrückständen mit GC-MS -
Retentionszeiten, Parameter für die Massenspektrometrie und Detektionsempfindlichkeit
Analyse des produits alimentaires - Détermination des résidus de pesticides par CG-SM
- Temps de rétention, paramètres de spectrométrie de masse et information sur la
réponse des détecteurs
Ta slovenski standard je istoveten z: CEN/TR 16468:2013
ICS:
65.100.01 Pesticidi in druge Pesticides and other
agrokemikalije na splošno agrochemicals in general
67.050 Splošne preskusne in General methods of tests and
analizne metode za živilske analysis for food products
proizvode
SIST-TP CEN/TR 16468:2013 en,fr,de
2003-01.Slovenski inštitut za standardizacijo. Razmnoževanje celote ali delov tega standarda ni dovoljeno.
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SIST-TP CEN/TR 16468:2013
TECHNICAL REPORT
CEN/TR 16468
RAPPORT TECHNIQUE
TECHNISCHER BERICHT
March 2013
ICS 65.100.01; 67.050
English Version
Food analysis - Determination of pesticide residues by GC-MS -
Retention times, mass spectrometric parameters and detector
response information
Analyse des produits alimentaires - Détermination des Lebensmitteluntersuchung - Bestimmung von
résidus de pesticides par CG-SM - Temps de rétention, Pestizidrückständen mit GC-MS - Retentionszeiten,
paramètres de spectrométrie de masse et information sur Parameter für die Massenspektrometrie und
la réponse des détecteurs Detektionsempfindlichkeit
This Technical Report was approved by CEN on 3 December 2012. It has been drawn up by the Technical Committee CEN/TC 275.
CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia,
Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania,
Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and United
Kingdom.
EUROPEAN COMMITTEE FOR STANDARDIZATION
COMITÉ EUROPÉEN DE NORMALISATION
EUROPÄISCHES KOMITEE FÜR NORMUNG
Management Centre: Avenue Marnix 17, B-1000 Brussels
© 2013 CEN All rights of exploitation in any form and by any means reserved Ref. No. CEN/TR 16468:2013: E
worldwide for CEN national Members.
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Contents Page
Foreword . 3
Introduction . 4
1 Scope . 5
2 Analyte specific parameters for gas chromatographic determination of pesticides . 5
2.1 General . 5
2.2 GC-MS, GC-ECD and GC-NPD Parameters . 5
2.3 Analyte specific retention times and MS parameters . 6
Bibliography. 24
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Foreword
This document (CEN/TR 16468:2013) has been prepared by Technical Committee CEN/TC 275 “Food
analysis - Horizontal methods”, the secretariat of which is held by DIN.
Attention is drawn to the possibility that some of the elements of this document may be the subject of patent
rights. CEN [and/or CENELEC] shall not be held responsible for identifying any or all such patent rights.
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Introduction
Pesticide residue analysis employs multiple methods involving extraction of residues from foods and clean-up
of the extract to obtain as many analytes as possible in the purified extracts. Afterwards the extracts can be
analysed by different kinds of instruments.
The hyphenation of gas chromatography (GC) and mass spectrometry (MS) is one of the most often used
universal and selective analysis techniques for identification and quantification of pesticide residues in food
extracts.
For the ionisation of the analytes (pesticides and/or their metabolites) in GC-MS, electron impact ionisation
(EI) is most commonly used. If the typical electron energy of 70 eV is used, very often molecular ions (cation
radicals) and several fragment ions are formed simultaneously.
The selective determination of each target analyte is performed by simultaneous aquisition of typically three
ions formed by the analyte in the selected ion monitoring (SIM) mode. The diagnostic value of an ion depends
on its mass. Usually even-numbered, high mass ions are less frequently formed and their recording results in
more specific chromatograms. A reduction of selectivity may be caused by background ions formed during
‘column bleeding’ or by sample matrix (e.g. typical ions from fatty of fruit acids or hydrocarbons).
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1 Scope
This Technical Report lists mass spectrometric parameters which are useful for the application of European
Standards for the determination of pesticide residues in foods that use GC-MS, such as the following
standards:
EN 1528 (all parts), Fatty food — Determination of pesticides and polychlorinated biphenyls (PCBs);
EN 12393 (all parts), Foods of plant origin — Multiresidue methods for the gas chromatographic
determination of pesticide residues;
EN 15662, Foods of plant origin — Determination of pesticide residues using GC-MS and/or LC-MS/MS
following acetonitrile extraction/partitioning and clean-up by dispersive SPE — QuEChERS-method.
To facilitate the determination of pesticides and/or metabolites using GC-MS, Table 1 specifies the diagnostic
ions suitable for quantification, which can be used.
2 Analyte specific parameters for gas chromatographic determination of pesticides
2.1 General
All values indicated in Table 1 were acquired using GC-MS, GC-ECD or GC-NPD systems under the
experimental conditions as outlined in 2.2. Comparative investigations showed that these parameters can be
transferred simply on instruments of other types of the same or other manufacturers [1].
2.2 GC-MS, GC-ECD and GC-NPD Parameters
The following GC operating conditions have been proven to be satisfactory. This is an example for appropriate
experimental conditions. Equivalent conditions may be used if they can be shown to lead to the same results.
Gas chromatograph Agilent model 6890
Carrier gas Helium, constant flow 1,0 ml/min (typical pressure at 70 °C is 61 kPa)
Injection technique Pulsed splitless, 200 kPa; Pulse time 1,0 min
Injector temperature 240 °C
Injection liner single taper, splitless (Agilent 5181-3316)
Injection volume 1 µl or 2 µl
Purge Gas Helium; purge flow to split vent 50 ml/min; Purge time 1,5 min
Column Fused silica capillary column HP-5MS, length 30 m, inner diameter 0,25 mm,
film thickness 0,25 µm (Agilent Nr. 19091S-433)
Temperature programme 2 min 70 °C, programmed to rise at 25 °C/min to 170 °C, at 3 °C/min to
210 °C, at 30 °C/min to 290 °C, then isothermal for 9 min
Transfer Line Temperatur 280 °C
Mass spectrometer Agilent MSD 5973N inert
MS temperatures Quadrupole 150 °C; Source 230 °C;
Ionisation Electron impact 70 eV
Solvent Delay 4,0 min
Retention time of parathion 15,85 min (parathion is used for calculation of relative retention times)
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As an alternative to the abovementioned fused silica capillary column HP-5MS a column DB-35MS can be
used. This column requires some slightly changed conditions.
Column Fused silica capillary column DB-35MS, length 30 m, inner diameter
0,25 mm, film thickness 0,25 µm (Agilent Nr. 122-3832)
Carrier gas/MS detection Hydrogen, constant flow 1,1 ml/min (typical pressure at 80 °C is
15,9 kPa)
Carrier gas/NPD and ECD detection Hydrogen, constant flow 1,9 ml/min (typical pressure at 80 °C is
88,3 kPa)
Temperature programme 1,8 min 80 °C, programmed to rise at 30 °C/min to 190 °C, at 6 °C/min to
240 °C, at 30 °C/min to 290 °C, then isothermal for 12 min
Injection technique/MS detection Pulsed splitless, 80 kPa; Pulse time 1,5 min
Injection technique/NPD and ECD, parallel detection
Pulsed splitless, 172 kPa; Pulse time 1,5 min
Injector temperature 240 °C
Injection liner single taper, splitless (Agilent 5181-3316)
Injection volume 2 µl
Purge Gas nitrogen; purge flow to split vent 35 ml/min; Purge time 2,0 min
Detector split ratio 1:5 (ECD:NPD; post column)
Detector temperature (NPD) 280 °C
Detector temperature (ECD) 300 °C
Transfer line temperature (MS) 280 °C
Mass spectrometer Agilent MSD 5973N
MS temperatures Quadrupole 150 °C; Source 230 °C;
Ionisation Electron impact 70 eV
Solvent Delay/MS 4,0 min
Retention time of parathion 14,69 min (RT parathion with GC NPD/ECD is used for calculation of
relative retention times)
As slight fluctuations in the measurement conditions influence the retention time, usually relative retention
times (RRT), related to a standard substance, are compared. The standard substance for the calculation of
the RRT values in the tables was parathion (RRT = 1,000).
2.3 Analyte specific retention times and MS parameters
The analyte specific parameters for selected ion monitoring (SIM) of pesticides by GC-MS with EI ionisation
are listed in Table 1. These data are completed by some indications about the sensitivity of detection, which
can be expected if GC-MS with the most intense ion and GC-ECD or GC-NPD are used. The names of the
individual active substances are supplemented by the CAS number (Chemical Abstracts Service), which is
useful for the search in data bases. It is usually taken from [2], but there can be several numbers in individual
cases, e.g. for isomers and racemates.
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The RRT data for columns HP-5MS and DB-35MS in Table 1 are relative retention times compared to
parathion (RRT = 1,00). The units for numbers presented in columns Ion 1 to Ion 4 are Da (or m/z). Three
crosses in the columns MSD, ECD or NPD indicate a better sensitivity compared to two or one crosses.
Table 1 — Parameters of 691 analytes
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Acephate 30560-19-1 0,47 0,58 136 94 95 96 xx x xx
Aclonifen 74070-46-5 1,40 1,34 264 266 212 77 xxx x x
Acrinathrin, 1 101007-06-1 1,57 1,41 207 181 281 208 xx xxx xx
Acrinathrin, 2 101007-06-1 1,58 1,46 181 208 207 93 xxx xxx xx
Alachlor 15972-60-8 0,89 0,88 160 188 146 237 xxx xxx x
Aldicarb, -sulfone 1646-88-4 0,33 0,43 68 80 65 69 xx x x
Aldrin 309-00-2 0,97 0,93 263 66 265 261 xxx xxx
Allidochlor 93-71-0 0,40 0,47 56 138 132 70 xxx xx xx
Ametryn 834-12-8 0,89 0,93 227 212 170 185 xxx xx
Amidithion 919-76-6 0,96 1,03 125 131 93 143 x x x
Aminocarb 2032-59-9 0,73 0,79 151 150 136 208 xx xx
Amitraz 33089-61-1 1,56 1,46 121 162 132 293 xx x
Amitraz hydrolysis product
95-68-1 0,35 0,41 121 120 106 77 xxx x
(Dimethylaniline, 2,4,-
Amitraz-metabolite (BTS 27271) 33089-74-6 0,55 0,61 162 132 120 106 x xx
Ancymidol 12771-68-5 1,36 1,30 228 107 121 215 xx xxx
Anilazine 101-05-3 1,09 1,11 239 241 178 143 x xx x
Anilofos 64249-01-0 1,53 1,46 226 125 184 334 xx xx xx
Aramite, 1 140-57-8 1,32 1,20 185 175 319 334 x x
Aramite, 2 140-57-8 1,35 1,22 185 175 319 334 x x
Aspon 3244-90-4 0,99 0,90 211 210 253 378 xxx xx xxx
Atraton 1610-17-9 0,69 0,74 196 211 169 154 xx x
Atrazine 1912-24-9 0,71 0,76 200 215 202 173 xxx x xxx
Atrazine, -desethyl 6190-65-4 0,63 0,71 172 174 187 145 xx x x
Atrazine, -desethyl-desisopropyl 3397-62-4 0,56 0,66 145 110 68 147 x x xx
Atrazine, -desisopropyl 1007-28-9 0,61 0,72 173 158 145 68 x x x
Azaconazole 60207-31-0 1,32 1,30 217 219 173 175 xx x xx
Azamethiphos 35575-96-3 1,44 1,39 215 155 125 109 x x xx
Azinphos-ethyl 2642-71-9 1,55 1,59 132 160 77 105 x xx xxx
Azinphos-methyl 86-50-0 1,55 1,55 160 132 77 105 xx xx xxx
Azobenzene 103-33-3 0,60 0,66 77 182 105 51 x x xxx
Azoxystrobin 131860-33-8 1,82 2,28 344 388 345 372 xx xx x
Beflubutamid 113614-08-7 1,13 1,03 91 176 221 193 xx x x
Benalaxyl 71626-11-4 1,45 1,35 148 91 206 204 xxx x
Benazolin-ethyl 25059-80-7 1,09 1,13 170 271 198 134 xxx xxx x
Benfluralin 1861-40-1 0,64 0,61 292 264 276 335 xx xxx xx
Benfuracarb 82560-54-1 1,58 1,50 190 163 164 102 xx x xx
Benfuresate 68505-69-1 0,84 0,90 163 256 121 164 xxx x x
Benodanil 15310-01-7 1,43 1,38 231 323 203 76 xxx xx x
Benoxacor 98730-04-2 0,82 0,87 120 259 261 176 xx xxx xx
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Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Bentazone-methyl 61592-45-8 0,89 0,94 212 105 254 133 xxx x xx
Benzoylprop-ethyl 22212-55-1 1,50 1,39 105 77 292 294 xxx xx x
Bifenazate 149877-41-8 1,52 1,44 300 258 199 196 xx x
Bifenazate-metabolite
39811-17-1 0,95 1,01 184 156 199 x x x
(5-Phenyl-o-anisidine)
Bifenox 42576-02-3 1,53 1,46 341 343 310 173 xx xxx x
Bifenthrin 82657-04-3 1,52 1,36 181 165 166 182 xxx xxx
Binapacryl 485-31-4 1,37 1,22 83 55 84 53 x x x
Bioallethrin S-cyclopentyl (Esbiol) 28434-00-6 1,12 1,00 123 136 79 107 xx xxx
Bioallethrin, cis- (Allethrin) 584-79-2 1,11 1,00 123 136 79 91 x xxx
Bioallethrin, trans- (Allethrin) 584-79-2 1,12 1,00 123 136 79 91 xx xxx
Bioresmethrin 28434-01-7 1,49 1,35 123 171 143 128 xxx x
Biphenyl 92-52-4 0,45 0,51 154 153 152 155 xxx
Bitertanol, 1 70585-36-3 1,60 1,55 170 168 171 112 xx x x
Bitertanol, 2 70585-38-5 1,61 1,57 170 168 171 112 xx x x
Boscalid 188425-85-6 1,67 1,78 140 342 142 344 xx xxx xx
Bromacil 314-40-9 0,96 1,05 205 207 206 188 x xx xx
Metobromuron-metabolite
106-40-1 0,41 0,49 171 173 92 65 xxx x x
(4-Bromoaniline)
Bromfenvinfos, (E)- 58580-14-6 1,24 1,13 267 269 323 325 xx xx x
Bromfenvinfos, (Z)- 58580-13-5 1,20 1,19 267 269 323 325 x xx x
Bromocyclen 1715-40-8 0,81 0,80 357 359 361 355 xxx xxx
Bromophos 2104-96-3 1,04 1,03 331 329 125 333 xxx xxx xxx
Bromophos-ethyl 4824-78-6 1,17 1,09 359 303 357 97 xxx xxx xxx
Bromopropylate 18181-80-1 1,51 1,40 341 343 339 183 xxx xxx
Bromuconazole, cis- 116255-48-2 1,51 1,44 173 295 175 293 xxx x xx
Bromuconazole, trans- 116255-48-2 1,53 1,48 173 175 295 293 xxx x xx
Bupirimate 41483-43-6 1,34 1,24 273 208 316 166 xxx xx xx
Buprofezin 69327-76-0 1,31 1,20 105 172 106 175 xxx x x
Butachlor 23184-66-9 1,21 1,08 176 160 57 188 xxx xxx xc
Butafenacil 134605-64-4 1,63 1,58 331 333 180 332 xx xx x
Butamifos 36335-67-8 1,24 1,17 286 200 232 202 x xxx xxx
Butralin 33629-47-9 1,05 0,95 266 224 295 267 xx xx x
Butylate 2008-41-5 0,47 0,50 57 146 156 174 xx xx
Cadusafos 95465-99-9 0,65 0,67 159 158 88 97 xxx xxx xxx
Cafenstrole 125306-83-4 1,64 1,68 100 188 72 119 xx xx x
Captafol 2425-06-1 1,48 1,43 79 80 77 183 xx x x
Captan 133-06-2 1,11 1,19 79 149 77 80 xx xx x
Captan-metabolite
1469-48-3 0,50 0,62 79 151 80 77 xxx x x
(Tetrahydrophthalimide)
Carbaryl-GC-artifact (1-Naphthol) 90-15-3 0,52 0,53 144 115 116 145 xx
Carbetamide 16118-49-3 1,03 1,04 119 120 91 64 x
Carbofuran 1563-66-2 0,70 0,80 164 149 131 122 xx x
Carbofuran, -phenol 1563-38-8 0,42 0,46 164 149 131 122 xx x
Carbophenothion 786-19-6 1,45 1,34 157 342 121 153 xxx xx xxx
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Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Carbosulfan 55285-14-8 1,51 1,37 160 118 163 164 xx x xx
Carboxin 5234-68-4 1,30 1,30 143 235 87 236 xx x x
Carfentrazone-ethyl 128639-02-1 1,46 1,32 312 340 330 290 x xx xx
Carvone 99-49-0 0,39 0,44 82 108 93 54 xxx
Chinomethionat 2439-01-2 1,15 1,20 206 234 116 148 x xxx xxx
Chlorbicyclen 2550-75-6 1,09 1,04 229 272 237 273 xx xxx
Chlordimeform-metabolite
95-69-2 0,41 0,48 141 106 140 143 xx x xx
(Chloro-2-methyl-aniline)
Metoxuron-metabolite
5345-54-0 0,48 0,57 142 157 114 144 xx x xx
(3-Chlor-4-methoxyaniline)
Chloroaniline, 3-
108-42-9 0,36 0,44 127 129 65 92 xx xx x
(Carbamate-hydrolysis product)
Chloroaniline, 4-
106-47-8 0,37 0,44 127 129 65 92 xxx xx x
(Monuron-hydrolysis product)
Chlorbenside 103-17-3 1,14 1,14 125 127 268 270 xx xx
Chlorbenside, -sulfone 7082-99-7 1,44 1,39 125 127 89 126 xx xxx
Chlorobenzilate 510-15-6 1,39 1,26 251 253 139 111 xx xx
Chlorbufam 1967-16-4 0,70 0,75 223 127 164 225 xx x x
Chlordane, cis- 5103-71-9 1,20 1,13 375 373 377 371 xxx xxx
Chlordane, oxy- 27304-13-8 1,09 1,02 115 185 387 187 xxx xxx
Chlordane, trans- 5103-74-2 1,15 1,11 373 375 377 371 xxx xxx
Chlordene, trans- 3734-48-3 0,77 0,77 66 237 101 232 xxx xxx
Chlordimeform 6164-98-3 0,63 0,68 196 181 117 152 xxx xx
Chlorethoxyfos 54593-83-8 0,59 0,61 153 97 301 299 xxx xxx xx
Chlorfenapyr 122453-73-0 1,37 1,24 59 247 328 408 xx xx xx
Chlorfenethol (BCPE) 80-06-8 1,10 1,10 251 139 253 111 x x
Chlorfenprop-methyl 14437-17-3 0,57 0,63 125 165 196 197 xx xxx
Chlorfenson 80-33-1 1,23 1,24 175 111 302 177 xx xxx
Chlorfenvinphos, (E)- 18708-86-6 1,08 1,03 267 269 323 325 xxx xx x
Chlorfenvinphos, (Z)- 18708-87-7 1,12 1,09 267 323 269 325 xxx xx x
Chlorflurenol-methyl 2536-31-4 1,15 1,18 215 152 217 274 xxx xxx
Chloridazon (Pyrazon) 1698-60-8 1,46 1,45 221 77 220 223 x x x
Chlormephos 24934-91-6 0,48 0,54 121 97 234 154 xx xx xxx
Chlornitrofen 1836-77-7 1,44 1,34 317 319 287 289 x xxx x
Chloroneb 2675-77-6 0,52 0,58 191 193 206 208 xxx xx
Chlorpropham 101-21-3 0,62 0,66 127 213 171 154 xx x x
Chloropropylate 5836-10-2 1,38 1,24 251 253 139 111 xxx xx
Chlorpyrifos 2921-88-2 1,00 0,97 197 199 314 97 xxx xxx xxx
Chlorpyrifos-methyl 5598-13-0 0,87 0,89 286 288 125 290 xxx xxx xxx
Chlorthal-dimethyl 1861-32-1 1,02 0,97 301 299 303 332 xxx xxx
Chlorothalonil 1897-45-6 0,79 0,91 266 264 268 270 xx xxx x
Chlorthiamide 1918-13-4 0,85 1,00 170 172 205 171 x x x
Chlorthion 500-28-7 1,02 1,04 109 125 297 299 x xxx xxx
Chlorthiophos, 1 21923-23-9 1,38 1,26 222 224 257 97 x xxx xx
Chlorthiophos, 2 77503-29-8 1,40 1,28 269 325 271 97 xx xxx xx
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Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Chlorthiophos, 3 77503-28-7 1,42 1,30 269 325 97 271 xx xxx xx
Chlorotoluron 15545-48-9 0,38 0,42 132 167 169 166 xxx x x
Chlozolinate 72391-46-9 1,11 1,04 259 188 331 186 xx xxx x
Cinerin I (Pyrethrins compound) 25402-06-6 1,34 1,14 123 121 150 93 xx x
Cinerin II (Pyrethrins compound) 121-20-0 1,55 1,42 107 121 93 91 xx x
Cinidon-ethyl 142891-20-1 1,91 2,33 330 332 358 331 xx xx x
Clodinafop-propargyl 105512-06-9 1,47 1,36 349 238 266 351 x x x
Clomazone 81777-89-1 0,71 0,77 125 204 127 205 xx x xx
Cloquintocet-mexyl 99607-70-2 1,52 1,42 192 194 193 163 x xx x
Coumaphos 56-72-4 1,62 1,62 362 226 109 364 xx xx xxx
Crimidine 535-89-7 0,52 0,61 142 156 171 144 xx x xx
Crotoxyphos 7700-17-6 1,15 1,12 127 105 193 166 x xx xx
Crufomate 299-86-5 1,03 1,04 256 182 276 169 xx x xx
Cyanazine 21725-46-2 1,01 1,08 225 172 198 212 xx xx xxx
Cyanofenphos 13067-93-1 1,45 1,37 157 169 141 185 xxx xx xxx
Cyanophos 2636-26-2 0,74 0,82 243 109 125 79 xx x xxx
Cycloate 1134-23-2 0,61 0,64 83 154 55 72 xxx x
Cyflufenamid 180409-60-3 1,37 1,23 91 55 412 294 xxx xxx xx
Cyfluthrin, beta-1 68359-37-5 1,64 1,59 163 165 206 226 xx xx x
Cyfluthrin, beta-2 68359-37-5 1,64 1,60 163 165 206 226 xx xx x
Cyfluthrin, beta-3 68359-37-5 1,65 1,61 163 165 206 226 xx xx x
Cyfluthrin, beta-4 68359-37-5 1,65 1,61 163 165 206 226 xx xx x
Cyhalofop-butyl 122008-85-9 1,56 1,47 256 357 229 228 xx x x
Cyhalothrin, lambda- 91465-08-6 1,57 1,44 181 197 208 209 xxx xxx xx
Cyhalothrin, cis- 68085-85-8 1,57 1,42 181 197 208 209 xxx xx x
Cymiazole 61676-87-7 0,88 0,94 144 218 115 119 xxx x x
Cymoxanil 57966-95-7 0,59 0,65 111 167 70 183 x x
Cypermethrin, zeta-1 52315-07-8 1,66 1,64 163 181 165 209 xx xx x
Cypermethrin, zeta-2 52315-07-8 1,66 1,65 163 181 165 209 xx xx x
Cypermethrin, zeta-3 52315-07-8 1,67 1,66 163 181 165 209 xx xx x
Cypermethrin, zeta-4 52315-07-8 1,67 1,66 163 181 165 209 xx xx x
Cypermethrin, alpha- 67375-30-8 1,67 1,66 163 181 165 209 xx xx x
Cyphenothrin, cis- 39515-40-7 1,59 1,49 123 181 375 167 xx xx x
Cyphenothrin, trans- 39515-40-7 1,59 1,50 123 181 375 167 xx xx x
Cyproconazole, (2RS + 3RS) 94361-06-5 1,35 1,28 222 139 224 125 xx xx xx
Cyproconazole, (2RS + 3SR) 94361-07-6 1,35 1,29 222 139 224 125 xx xx xx
Cyprodinil 121552-61-2 1,07 1,06 224 225 210 226 xxx xxx
Cyprofuram 69581-33-5 1,40 1,35 69 211 213 279 xx xxx xxx
DDD, -ethyl (Perthane) 72-56-0 1,37 1,25 223 224 165 178 xxx x
DDD, 2,4- 53-19-0 1,30 1,24 235 237 165 236 xxx xxx
DDD, 4,4- 72-54-8 1,40 1,31 235 237 165 236 xxx xxx
DDE, 2,4- 3424-82-6 1,17 1,11 246 248 318 316 xxx xxx
DDE, 4,4- 72-55-9 1,27 1,19 246 318 316 248 xxx xxx
10
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SIST-TP CEN/TR 16468:2013
CEN/TR 16468:2013 (E)
Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
DDT, 2,4- 789-02-6 1,41 1,29 235 237 165 236 xxx xxx
DDT, 4,4- 50-29-3 1,46 1,35 235 237 165 236 xxx xxx
Diethyltoluamide (DEET) 134-62-3 0,56 0,62 119 190 191 91 xxx xx
Deltamethrin 52918-63-5 1,79 1,91 181 253 251 255 xx xxx x
Demeton-S-methyl 919-86-8 0,59 0,67 88 60 109 142 xx x xxx
Demeton-S-methyl, -sulfone 17040-19-6 0,92 1,06 169 109 125 142 xx xx xx
Desmetryn 1014-69-3 0,84 0,90 213 198 171 82 xxx xxx
Dialifos 10311-84-9 1,59 1,56 208 210 357 209 xx xx xx
Di-allate, cis- 2303-16-4 0,66 0,67 86 234 128 236 xxx xx x
Di-allate, trans- 2303-16-4 0,67 0,69 234 86 236 128 xxx xx x
Diazinon 333-41-5 0,76 0,75 179 137 304 152 xxx xxx xxx
Diazinon, -oxon 962-58-3 0,73 0,75 273 137 288 151 x x xx
Brompropylate-metabolite
3988-03-2 1,33 1,29 183 185 340 338 xx xx
(Dibromobenzophenone, 4,4-)
Dichlobenil 1194-65-6 0,43 0,51 171 173 136 100 xxx xxx x
Dichlofenthion 97-17-6 0,85 0,84 279 223 97 281 xxx xx xxx
Dichlofluanid 1085-98-9 0,96 0,99 123 224 167 226 xxx xxx x
Dichlofluanid-metabolite (DMSA) 2418-14-6 0,62 0,74 200 92 65 93 x x
Dichlone 117-80-6 0,77 0,87 228 191 163 230 x x
Dichlobenil-metabolite
2008-58-4 0,63 0,76 173 175 189 191 xxx xxx x
(2,6-Dichlorbenzamide)
Dichloraniline, 3,5- 626-43-7 0,47 0,54 161 163 90 99 xxx xx x
Dichlormid 37764-25-3 0,43 0,49 172 124 166 174 xxx xxx xx
Dichlorprop-methyl 57153-17-0 0,63 0,63 162 164 189 248 xx x
Dichlorvos 62-73-7 0,38 0,45 109 185 79 145 xx x xxx
Diclobutrazol, cis- 66345-62-8 1,31 1,22 270 272 159 161 xx xx xx
Diclobutrazol, trans- 66345-62-8 1,37 1,26 270 272 159 161 xx xx xx
Diclofop-methyl 51338-27-3 1,48 1,37 253 340 255 342 xx x
Dicloran 99-30-9 0,69 0,79 206 124 176 208 x xxx x
Dicofol, 2,4- 10606-46-9 1,54 1,38 139 251 253 141 xx x
Dicofol, 4,4- 115-32-2 1,52 1,38 139 251 253 111 xx x
Dicofol-2.4-metabolite
85-29-0 0,92 0,96 139 250 141 111 xxx xxx
(2,4-Dichlorobenzophenone)
Dicofol-4.4-metabolite
90-98-2 1,00 1,03 139 250 111 141 xxx xxx
(4,4-Dichlorobenzophenone)
Dicrotophos, -(E) 141-66-2 0,63 0,72 127 67 193 237 xx x x
Dicrotophos, -(Z) 18250-63-0 0,59 0,72 127 67 193 237 xx x x
Dieldrin 60-57-1 1,27 1,21 79 263 277 279 xxx xxx
Dienochlor 2227-17-0 0,42 0,42 203 201 205 238 xx x
Diethofencarb 87130-20-9 0,98 0,96 267 225 124 151 xx xx
Difenoconazole, cis- 119446-68-3 1,76 1,97 323 265 325 267 x xx x
Difenoconazole, trans- 119446-68-3 1,77 1,98 323 265 325 267 x xx x
Diflufenican 83164-33-4 1,49 1,35 266 394 267 246 x xxx x
Dimefox 115-26-4 0,27 0,33 110 154 153 111 xxx xx
11
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SIST-TP CEN/TR 16468:2013
CEN/TR 16468:2013 (E)
Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Dimepiperate 61432-55-1 1,12 1,13 119 118 117 91 xx x x
Dimethachlor 50563-36-5 0,85 0,88 134 197 132 210 xxx xx x
Dimethenamid-P 163515-14-8 0,85 0,86 154 230 203 232 xxx xx xx
Dimethipin 55290-64-7 0,71 0,90 54 53 118 76 xx xxx x
Dimethoate 60-51-5 0,69 0,81 87 93 125 143 xx x xxx
Dimethomorph, (E)- 110488-70-5 1,83 2,26 301 387 303 165 x xx x
Dimethomorph, (Z)- 110488-70-5 1,82 2,17 301 303 387 165 x xx x
Dimoxystrobin 149961-52-4 1,52 1,42 116 205 58 295 xx x xx
Diniconazole 83657-24-3 1,39 1,29 268 270 70 269 xx xx x
Dinobuton 973-21-7 1,14 1,04 211 205 163 240 xx xx x
Dinocap, 4-ethyl-hexyl- 39300-45-3 1,52 1,37 69 -- -- -- x x x
Dinocap, 4-methyl-heptyl- 39300-45-3 1,52 1,37 69 -- -- -- x x x
Dinocap, 4-propyl-pentyl- 39300-45-3 1,51 1,35 69 -- -- xxx x x
Dinocap, 6-ethyl-hexyl- 39300-45-3 1,49 1,31 69 -- -- -- x x x
Dinocap, 6-methyl-heptyl- 39300-45-3 1,49 1,31 69 -- -- -- x x x
Dinocap, 6-propyl-pentyl- 39300-45-3 1,50 1,33 69 -- -- -- x x x
Dinoseb acetate 2813-95-8 0,91 0,89 240 211 163 89 x xxx x
Diofenolan, cis- 63837-33-2 1,45 1,33 186 300 225 301 xx
Diofenolan, trans- 63837-33-2 1,46 1,34 186 300 225 301 xx
Dioxacarb 6988-21-2 0,46 0,95 121 166 165 122 xx
Dioxacarb-metabolite (-phenol) 6988-19-8 0,46 0,55 121 166 165 122 x
Dioxathion 78-34-2 0,73 0,80 97 125 270 73 xx xx xxx
Diphenylamine 122-39-4 0,60 0,67 169 168 167 170 xxx xxx
Dipropetryn 4147-51-7 0,97 0,95 255 240 184 222 xxx xx
Di-n-propyl isocinchomeronate 136-45-8 0,87 0,86 165 179 192 164 xx xx xx
Disulfoton 298-04-4 0,77 0,79 88 89 97 142 xx x xxx
Disulfoton, -oxon 126-75-0 0,68 0,73 88 60 170 126 xx xxx xxx
Disulfoton, -sulfone 2497-06-5 1,20 1,23 213 153 97 125 x x x
Disulfoton, -sulfoxide 2497-07-6 0,42 0,48 97 125 212 153 xx x
Ditalimfos 5131-24-8 1,22 1,23 130 148 299 209 xx xx xxx
DNOC 534-52-1 1,26 0,69 198 105 121 168 x x
Dodemorph, cis- 1593-77-7 1,04 0,90 154 281 238 141 xxx xx
Dodemorph, trans- 1593-77-7 1,08 0,94 154 281 238 141 xxx xx
Edifenphos 17109-49-8 1,45 1,40 109 173 310 201 xx x xx
Empenthrin, 1 54406-48-3 0,66 0,60 123 91 81 79 xx x
Empenthrin, 2 54406-48-3 0,67 0,61 123 91 81 79 xx x
Empenthrin, 3 54406-48-3 0,67 0,64 123 91 81 79 xx x
Empenthrin, 4 54406-48-3 0,68 0,64 123 91 81 79 xx x
Empenthrin, 5 54406-48-3 0,68 0,64 123 91 81 79 xx x
Endosulfan, alpha- 33213-66-0 1,19 1,14 241 237 195 239 xx xxx
Endosulfan, beta- 33213-65-9 1,37 1,32 195 237 241 207 xx xxx
Endosulfan, -sulfate 1031-07-8 1,45 1,38 272 274 387 237 xx xxx
Endrin 72-20-8 1,34 1,28 263 265 281 261 xxx xxx
12
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SIST-TP CEN/TR 16468:2013
CEN/TR 16468:2013 (E)
Table 1 (continued)
RRT RRT
Pesticide name CAS-Nr. Ion1 Ion2 Ion3 Ion4 MSD ECD NPD
HP5MS DB35MS
Endrin-metabolite
7421-93-4 1,41 1,35 345 67 250 347 xx xx
(Endrin-aldehyde)
Endrin-metabolite (Endrin-keton) 53494-70-5 1,50 1,31 317 315 319 281 xx x
EPN 2104-64-5 1,52 1,43 157 169 185 141 xx xx x
Epoxiconazole, cis- 106325-08-0 1,45 1,36 192 194 138 165 xx xx xx
Epoxiconazole, trans- 106325-08-0 1,49 1,41 192 194 138 165 xx xx xx
EPTC 759-94-4 0,43 0,48 128 86 132 189 xx x xx
Esfenvalerate 66230-04-4 1,74 1,82 125 167 181 152 xx xx x
Esprocarb 85785-20-2 0,95 0,93 91 222 162 71 xx xx
Etaconazole, cis- 60207-93-4 1,40 1,31 245 173 247 175 xx
Etaconazole, trans- 60207-93-4 1,41 1,31 245 173 247 55 xx
Ethiofencarb 29973-13-5 0,82 0,90 107 168 77 108 x xx
Ethiofencarb-metabolite
65370-06-1 0,47 0,54 107 168 77 78 xxx x xx
(2-Ethylthiomethylphenol)
Ethion 563-12-2 1,42 1,30 231 153 97 125 xxx xxx xxx
Ethirimol 23947-60-6 0,91 0,96 166 96 209 167 x
Ethofumesate 26225-79-6 0,95 0,97 207 161 286 137 xx x
Ethofumesate-metabolite
26244-33-7 0,85 0,96 149 177 256 77 xx xx xx
(2-Oxo-ethofumesate)
Ethoprophos 13194-48-4 0,60 0,65 158 97 139 126 xxx xx xx
Ethoxyfen-ethyl 131086-42-5 1,51 1,36 333 335 450 452 xxx xxx
Ethoxyquin 91-53-2 0,69 0,72 202 174 203 145 xx x
Etofenprox 80844-07-1 1,68 1,69 163 135 164 107 xxx
Etoxazole 153233-91-1 1,53 1,40 204 141 300 187 xx xx
Etridiazole 2593-15-9 0,49 0,54 211 183 213 185 xxx xx xx
Etridiazole-metabolite
A-108 0,43 0,49 149 184 141 186 xx x xx
(Etridiazole, -deschloro)
Etrimfos 38260-54-7 0,80 0,79 292 181 153 277 xx x xxx
Famoxadone 131807-57-3 1,83 2,22 330 329 196 197 x xx x
Famphur (Famophos) 52-85-7 1,45 1,37 218 125 217 93 x xxx xxx
Fenamidone 161326-34-7 1,53 1,47 238 268 237 206 xx xxx xxx
Fenamiphos 22224-92-6 1,24 1,20 303 154 288 217 x xxx
Fenamiphos, -s
...
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